scholarly journals TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

Cell ◽  
2012 ◽  
Vol 150 (3) ◽  
pp. 606-619 ◽  
Author(s):  
Vijay A.K. Rathinam ◽  
Sivapriya Kailasan Vanaja ◽  
Lisa Waggoner ◽  
Anna Sokolovska ◽  
Christine Becker ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Nlrp3 Inflammasome Activation

scholarly journals IRF8 Regulates Gram-Negative Bacteria–Mediated NLRP3 Inflammasome Activation and Cell Death

2020 ◽  
Vol 204 (9) ◽  
pp. 2514-2522 ◽  
Author(s):  
Rajendra Karki ◽  
Ein Lee ◽  
Bhesh R. Sharma ◽  
Balaji Banoth ◽  
Thirumala-Devi Kanneganti
Keyword(s):  
Cell Death ◽  
Nlrp3 Inflammasome ◽  
Inflammasome Activation ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Nlrp3 Inflammasome Activation

O008 Type I interferons license caspase-11-dependent NLRP3 inflammasome activation by Gram-negative bacteria

Cytokine ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 500
Author(s):  
V. Rathinam ◽  
S. Kailasan Vanaja ◽  
L. Waggoner ◽  
A. Sokolovska ◽  
C. Becker ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Type I Interferons ◽  
Inflammasome Activation ◽  
Type I ◽  
Gram Negative Bacteria ◽  
Gram Negative ◽  
Nlrp3 Inflammasome Activation

scholarly journals New insights in caspase-11 functions in noncanonical inflammasome signalling

Inflammasome ◽  
2014 ◽  
Vol 1 (1) ◽  
Author(s):  
Mélanie Bodnar ◽  
Virginie Petrilli
Keyword(s):  
Cell Death ◽  
Inflammatory Cell ◽  
Protein Complexes ◽  
Inflammasome Activation ◽  
Gram Negative Bacteria ◽  
Nucleotide Binding Domain ◽  
Gram Negative ◽  
Caspase 1 ◽  
Nlrp3 Inflammasome Activation ◽  
Dependent Pathway

AbstractInflammasomes are multi-protein complexes that play a crucial role in innate immunity. They are assembled by cytosolic sensors of the Nucleotide-binding domain and Leucine-rich repeat containing Receptor (NLR) and PYrin and HIN (PYHIN) domain-containing protein families upon sensing various pathogens and danger signals. Inflammasome formation culminates in caspase-1 activation, which causes the cleavage of pro-IL-1β and pro- IL-18 into active cytokines; this eventually results in the induction of an inflammatory cell death called pyroptosis. Recent data using Gram-negative bacteria suggests a role for caspase-11 not only in NLRP3 inflammasome activation but also in a caspase-1- and inflammasome-independent cell death. This novel caspase-11-dependent pathway is critical to control infection by Gram-negative bacteria and has been named the noncanonical inflammasome.

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