scholarly journals The Molecular Basis of CRL4DDB2/CSA Ubiquitin Ligase Architecture, Targeting, and Activation

Cell ◽  
2011 ◽  
Vol 147 (5) ◽  
pp. 1024-1039 ◽  
Author(s):  
Eric S. Fischer ◽  
Andrea Scrima ◽  
Kerstin Böhm ◽  
Syota Matsumoto ◽  
Gondichatnahalli M. Lingaraju ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis

scholarly journals Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4

Structure ◽  
2010 ◽  
Vol 18 (8) ◽  
pp. 955-965 ◽  
Author(s):  
Robert C. Benirschke ◽  
James R. Thompson ◽  
Yves Nominé ◽  
Emeric Wasielewski ◽  
Nenad Juranić ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
Conjugating Enzymes

scholarly journals F-Box Proteins and Cancer

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1249 ◽  
Author(s):  
Kanae Yumimoto ◽  
Yuhei Yamauchi ◽  
Keiichi I. Nakayama
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
Cancer Therapeutics ◽  
S Phase ◽  
Cancer Development ◽  
Tumor Promoters ◽  
Cellular Processes ◽  
Novel Targets ◽  
Scf Ubiquitin Ligase ◽  
F Box Protein

Controlled protein degradation is essential for the operation of a variety of cellular processes including cell division, growth, and differentiation. Identification of the relations between ubiquitin ligases and their substrates is key to understanding the molecular basis of cancer development and to the discovery of novel targets for cancer therapeutics. F-box proteins function as the substrate recognition subunits of S-phase kinase-associated protein 1 (SKP1)−Cullin1 (CUL1)−F-box protein (SCF) ubiquitin ligase complexes. Here, we summarize the roles of specific F-box proteins that have been shown to function as tumor promoters or suppressors. We also highlight proto-oncoproteins that are targeted for ubiquitylation by multiple F-box proteins, and discuss how these F-box proteins are deployed to regulate their cognate substrates in various situations.

scholarly journals Structural and molecular basis of ZNRF3/RNF43 transmembrane ubiquitin ligase inhibition by the Wnt agonist R-spondin

2013 ◽  
Vol 4 (1) ◽  
Author(s):  
Matthias Zebisch ◽  
Yang Xu ◽  
Christos Krastev ◽  
Bryan T. MacDonald ◽  
Maorong Chen ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis

scholarly journals Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch

2017 ◽  
Vol 292 (15) ◽  
pp. 6325-6338 ◽  
Author(s):  
Guillaume Desrochers ◽  
Laurent Cappadocia ◽  
Mathieu Lussier-Price ◽  
Anh-Tien Ton ◽  
Riham Ayoubi ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
Sh3 Domain ◽  
Rich Region ◽  
Proline Rich Region

Molecular basis for ubiquitin ligase CRL2FEM1C-mediated recognition of C-degron

2021 ◽  
Author(s):  
Xiaojie Yan ◽  
Xiaolu Wang ◽  
Yao Li ◽  
Mengqi Zhou ◽  
Yanjun Li ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Molecular Basis

scholarly journals Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e106547 ◽  
Author(s):  
Anupriya Gopalsamy ◽  
Thilo Hagen ◽  
Kunchithapadam Swaminathan
Keyword(s):  
Substrate Specificity ◽  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
E3 Ubiquitin Ligase

scholarly journals Molecular basis of cullin-3 (Cul3) ubiquitin ligase subversion by vaccinia virus protein A55

2019 ◽  
Vol 294 (16) ◽  
pp. 6416-6429 ◽  
Author(s):  
Chen Gao ◽  
Mitchell A. Pallett ◽  
Tristan I. Croll ◽  
Geoffrey L. Smith ◽  
Stephen C. Graham
Keyword(s):  
Vaccinia Virus ◽  
Ubiquitin Ligase ◽  
Molecular Basis ◽  
Virus Protein ◽  
Cullin 3
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