scholarly journals Functional and Mechanistic Diversity of Distal Transcription Enhancers

Cell ◽  
2011 ◽  
Vol 144 (3) ◽  
pp. 327-339 ◽  
Author(s):  
Michael Bulger ◽  
Mark Groudine
Keyword(s):  
Transcription Enhancers

scholarly journals Transcription enhancers as major determinants of SV40 polyomavirus growth efficiency and host cell tropism

2016 ◽  
Vol 97 (7) ◽  
pp. 1597-1603 ◽  
Author(s):  
Katharina Schmidt ◽  
Simon Keiser ◽  
Viola Günther ◽  
Oleg Georgiev ◽  
Hans H. Hirsch ◽  
...  
Keyword(s):  
Host Cell ◽  
Growth Efficiency ◽  
Cell Tropism ◽  
Transcription Enhancers

scholarly journals Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers

2015 ◽  
Vol 396 (4) ◽  
pp. 311-327 ◽  
Author(s):  
Walter Schaffner
Keyword(s):  
Developmental Stages ◽  
Simian Virus 40 ◽  
Cell Types ◽  
Simian Virus ◽  
Transcription Unit ◽  
Specific Gene ◽  
Base Pairs ◽  
Virus Transcription ◽  
Cellular Genes ◽  
Transcription Enhancers

Abstract Transcriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-type-specific gene expression. Enhancers can exert their effect over long distances of thousands, even hundreds of thousands of base pairs, either from upstream, downstream, or from within a transcription unit. The number of enhancers in eukaryotic genomes correlates with the complexity of the organism; a typical mammalian gene is likely controlled by several enhancers to fine-tune its expression at different developmental stages, in different cell types and in response to different signaling cues. Here, I provide a personal account of how enhancers were discovered more than 30 years ago, and also address the amazing development of the field since then.

scholarly journals Functional and Mechanistic Diversity of Distal Transcription Enhancers

Cell ◽  
2011 ◽  
Vol 144 (5) ◽  
pp. 825 ◽  
Author(s):  
Michael Bulger ◽  
Mark Groudine
Keyword(s):  
Transcription Enhancers

scholarly journals Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

2017 ◽  
Vol 27 (23) ◽  
pp. 5144-5148 ◽  
Author(s):  
Sungwoon Choi ◽  
Alyssa N. Calder ◽  
Eliza H. Miller ◽  
Kierstyn P. Anderson ◽  
Dawid K. Fiejtek ◽  
...  
Keyword(s):  
Motor Neuron ◽  
Gene Transcription ◽  
Survival Motor Neuron ◽  
Survival Motor Neuron Gene ◽  
Transcription Enhancers
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