scholarly journals Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Cell ◽  
2007 ◽  
Vol 130 (6) ◽  
pp. 1120-1133 ◽  
Author(s):  
Jixin Dong ◽  
Georg Feldmann ◽  
Jianbin Huang ◽  
Shian Wu ◽  
Nailing Zhang ◽  
...  
Keyword(s):  
Control Mechanism ◽  
Size Control

scholarly journals Determination of organ size: a need to focus on growth rate, not size

2020 ◽  
Vol 64 (4-5-6) ◽  
pp. 299-318
Author(s):  
Carmen M.A. Coelho
Keyword(s):  
Control Mechanism ◽  
Growth Control ◽  
Size Control ◽  
Organ Size ◽  
Cell Competition ◽  
The Past ◽  
Mechanistic Basis ◽  
Regulation Of Growth ◽  
Correct Size

The regulation of growth and the determination of organ-size in animals is an area of research that has received much attention during the past two and a half decades. Classic regeneration and cell-competition studies performed during the last century suggested that for size to be determined, organ-size is sensed and this sense of size feeds back into the growth control mechanism such that growth stops at the “correct” size. Recent work using Drosophila imaginal discs as a system has provided a particularly detailed cellular and molecular understanding of growth. Yet, a clear mechanistic basis for size-sensing has not emerged. I re-examine these studies from a different perspective and ask whether there is scope for alternate modes of size control in which size does not need to be sensed.

scholarly journals Size-Selected Synthesis of PtRu Nano-Catalysts:  Reaction and Size Control Mechanism

2004 ◽  
Vol 126 (25) ◽  
pp. 8028-8037 ◽  
Author(s):  
Christina Bock ◽  
Chantal Paquet ◽  
Martin Couillard ◽  
Gianluigi A. Botton ◽  
Barry R. MacDougall
Keyword(s):  
Control Mechanism ◽  
Size Control ◽  
Nano Catalysts

Understanding the Size Control Mechanism for Pt/C Catalysts Made Using the Polyol Method

2013 ◽  
pp. 165-172
Author(s):  
P.C. Favilla ◽  
J.J. Acosta ◽  
C.E. Schvezov ◽  
D.J. Sercovich ◽  
J.R. Collet-Lacoste
Keyword(s):  
Control Mechanism ◽  
Size Control ◽  
Polyol Method

Size control mechanism of ZnO nanoparticles obtained in microwave solvothermal synthesis

2018 ◽  
Vol 29 (6) ◽  
pp. 065601 ◽  
Author(s):  
Jacek Wojnarowicz ◽  
Tadeusz Chudoba ◽  
Iwona Koltsov ◽  
Stanislaw Gierlotka ◽  
Sylwia Dworakowska ◽  
...  
Keyword(s):  
Zno Nanoparticles ◽  
Solvothermal Synthesis ◽  
Control Mechanism ◽  
Size Control

scholarly journals Cortical regulation of cell size by a sizer cdr2p

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Kally Z Pan ◽  
Timothy E Saunders ◽  
Ignacio Flor-Parra ◽  
Martin Howard ◽  
Fred Chang
Keyword(s):  
Cell Division ◽  
Protein Kinase ◽  
Cell Surface ◽  
Surface Area ◽  
Control Mechanism ◽  
Size Control ◽  
Mitotic Entry ◽  
Medial Cortex ◽  
Peripheral Membrane Protein ◽  
Dose Dependent

Cells can, in principle, control their size by growing to a specified size before commencing cell division. How any cell actually senses its own size remains poorly understood. The fission yeast Schizosaccharomyces pombe are rod-shaped cells that grow to ∼14 µm in length before entering mitosis. In this study, we provide evidence that these cells sense their surface area as part of this size control mechanism. We show that cells enter mitosis at a certain surface area, as opposed to a certain volume or length. A peripheral membrane protein kinase cdr2p has properties of a dose-dependent ‘sizer’ that controls mitotic entry. As cells grow, the local cdr2p concentration in nodes at the medial cortex accumulates as a measure of cell surface area. Our findings, which challenge a previously proposed pom1p gradient model, lead to a new model in which cells sense their size by using cdr2p to probe the surface area over the whole cell and relay this information to the medial cortex.

scholarly journals Growth Rate and Cell Size Modulate the Synthesis of, and Requirement for, G1-Phase Cyclins at Start

2004 ◽  
Vol 24 (24) ◽  
pp. 10802-10813 ◽  
Author(s):  
Brandt L. Schneider ◽  
Jian Zhang ◽  
J. Markwardt ◽  
George Tokiwa ◽  
Tom Volpe ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Growth Rate ◽  
Cell Size ◽  
Cell Cycle Progression ◽  
Control Mechanism ◽  
Size Control ◽  
Small Cells ◽  
Critical Threshold ◽  
Cycle Progression

ABSTRACT In Saccharomyces cerevisiae, commitment to cell cycle progression occurs at Start. Progression past Start requires cell growth and protein synthesis, a minimum cell size, and G1-phase cyclins. We examined the relationships among these factors. Rapidly growing cells expressed, and required, dramatically more Cln protein than did slowly growing cells. To clarify the role of cell size, we expressed defined amounts of CLN mRNA in cells of different sizes. When Cln was expressed at nearly physiological levels, a critical threshold of Cln expression was required for cell cycle progression, and this critical threshold varied with both cell size and growth rate: as cells grew larger, they needed less CLN mRNA, but as cells grew faster, they needed more Cln protein. At least in part, large cells had a reduced requirement for CLN mRNA because large cells generated more Cln protein per unit of mRNA than did small cells. When Cln was overexpressed, it was capable of promoting Start rapidly, regardless of cell size or growth rate. In summary, the amount of Cln required for Start depends dramatically on both cell size and growth rate. Large cells generate more Cln1 or Cln2 protein for a given amount of CLN mRNA, suggesting the existence of a novel posttranscriptional size control mechanism.

scholarly journals Size Control Mechanism of RE123 LPE Film on BaZrO3 Buffered MgO Substrate for PCS Material

2003 ◽  
Vol 67 (4) ◽  
pp. 153-156 ◽  
Author(s):  
Masahiko Kai ◽  
Atsushi Inoue ◽  
Saburo Hoshi ◽  
Satoshi Koyama ◽  
Teruo Izumi ◽  
...  
Keyword(s):  
Control Mechanism ◽  
Size Control ◽  
Mgo Substrate
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