scholarly journals The Hippo Pathway Regulates the bantam microRNA to Control Cell Proliferation and Apoptosis in Drosophila

Cell ◽  
2006 ◽  
Vol 126 (4) ◽  
pp. 767-774 ◽  
Author(s):  
Barry J. Thompson ◽  
Stephen M. Cohen
Keyword(s):  
Cell Proliferation ◽  
Hippo Pathway ◽  
Control Cell ◽  
Proliferation And Apoptosis ◽  
The Hippo Pathway

scholarly journals Regulation and functions of the Hippo pathway in stemness and differentiation

2020 ◽  
Vol 52 (7) ◽  
pp. 736-748 ◽  
Author(s):  
Xiaolei Cao ◽  
Chenliang Wang ◽  
Jiyang Liu ◽  
Bin Zhao
Keyword(s):  
Cell Proliferation ◽  
Tissue Regeneration ◽  
Hippo Pathway ◽  
Binding Motif ◽  
Cell Fates ◽  
Self Renewal ◽  
Proliferation And Apoptosis ◽  
Kinase Cascade ◽  
The Hippo Pathway

Abstract The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and thus regulates transcription of genes important for cell proliferation and apoptosis. However, recent studies have depicted a much more complicate picture of the Hippo pathway with many new components and regulatory stimuli involving both chemical and mechanical signals. Furthermore, accumulating evidence indicates that the Hippo pathway also plays important roles in the determination of cell fates, such as self-renewal and differentiation. Here, we review regulations of the Hippo pathway and its functions in stemness and differentiation emphasizing recent discoveries.

scholarly journals NPHP4, a cilia-associated protein, negatively regulates the Hippo pathway

2011 ◽  
Vol 193 (4) ◽  
pp. 633-642 ◽  
Author(s):  
Sandra Habbig ◽  
Malte P. Bartram ◽  
Roman U. Müller ◽  
Ricarda Schwarz ◽  
Nikolaos Andriopoulos ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cellular Proliferation ◽  
Nuclear Translocation ◽  
Hippo Pathway ◽  
Negative Regulator ◽  
Hippo Signaling ◽  
Transcriptional Coactivator ◽  
Hippo Signaling Pathway ◽  
The Hippo Pathway ◽  
Potent Negative Regulator

The conserved Hippo signaling pathway regulates organ size in Drosophila melanogaster and mammals and has an essential role in tumor suppression and the control of cell proliferation. Recent studies identified activators of Hippo signaling, but antagonists of the pathway have remained largely elusive. In this paper, we show that NPHP4, a known cilia-associated protein that is mutated in the severe degenerative renal disease nephronophthisis, acts as a potent negative regulator of mammalian Hippo signaling. NPHP4 directly interacted with the kinase Lats1 and inhibited Lats1-mediated phosphorylation of the Yes-associated protein (YAP) and TAZ (transcriptional coactivator with PDZ-binding domain), leading to derepression of these protooncogenic transcriptional regulators. Moreover, NPHP4 induced release from 14-3-3 binding and nuclear translocation of YAP and TAZ, promoting TEA domain (TEAD)/TAZ/YAP-dependent transcriptional activity. Consistent with these data, knockdown of NPHP4 negatively affected cellular proliferation and TEAD/TAZ activity, essentially phenocopying loss of TAZ function. These data identify NPHP4 as a negative regulator of the Hippo pathway and suggest that NPHP4 regulates cell proliferation through its effects on Hippo signaling.

scholarly journals Cross-Talk Between Mitochondrial Fusion and the Hippo Pathway in Controlling Cell Proliferation During Drosophila Development

Genetics ◽  
2016 ◽  
Vol 203 (4) ◽  
pp. 1777-1788 ◽  
Author(s):  
Qiannan Deng ◽  
Ting Guo ◽  
Xiu Zhou ◽  
Yongmei Xi ◽  
Xiaohang Yang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cross Talk ◽  
Hippo Pathway ◽  
Mitochondrial Fusion ◽  
Drosophila Development ◽  
The Hippo Pathway

scholarly journals The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

Development ◽  
2010 ◽  
Vol 137 (24) ◽  
pp. 4147-4158 ◽  
Author(s):  
R. L. Shaw ◽  
A. Kohlmaier ◽  
C. Polesello ◽  
C. Veelken ◽  
B. A. Edgar ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Hippo Pathway ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation ◽  
The Hippo Pathway
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