scholarly journals Role of STIM1/ORAI1-mediated store-operated Ca2+ entry in skeletal muscle physiology and disease

Cell Calcium ◽  
2018 ◽  
Vol 76 ◽  
pp. 101-115 ◽  
Author(s):  
Antonio Michelucci ◽  
Maricela García-Castañeda ◽  
Simona Boncompagni ◽  
Robert T. Dirksen
Keyword(s):  
Skeletal Muscle ◽  
Muscle Physiology

The role of sphingosine‐1‐phosphate in skeletal muscle: Physiology, mechanisms, and clinical perspectives

2018 ◽  
Vol 234 (7) ◽  
pp. 10047-10059 ◽  
Author(s):  
André V. Cordeiro ◽  
Vagner R. R. Silva ◽  
José R. Pauli ◽  
Adelino S. R. da Silva ◽  
Dennys E. Cintra ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Physiology ◽  
Sphingosine 1 Phosphate

scholarly journals Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent

2020 ◽  
Author(s):  
Lien A. Phung ◽  
Aurora D. Foster ◽  
Mark S. Miller ◽  
Dawn A. Lowe ◽  
David D. Thomas
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Fiber Type ◽  
Vastus Lateralis ◽  
Epifluorescence Microscopy ◽  
Model Organisms ◽  
Muscle Physiology ◽  
Fiber Types ◽  
Mhc I

AbstractThe myosin super-relaxed state (SRX) in skeletal muscle is hypothesized to play an important role in regulating muscle contractility and thermogenesis in humans, but has only been examined in model organisms. Here we report the first human skeletal muscle SRX measurements, using quantitative epifluorescence microscopy of fluorescent 2’/3’-O-(N-methylanthraniloyl) ATP (mantATP) single-nucleotide turnover. Myosin heavy chain (MHC) isoform expression was determined using gel electrophoresis for each permeabilized vastus lateralis fiber, to allow for novel comparisons of SRX between fiber-types. We find that the fraction of myosin in SRX is less in MHC IIA fibers than in MHC I and IIAX fibers (p = 0.008). ATP turnover of SRX is faster in MHC IIAX fibers compared to MHC I and IIA fibers (p = 0.001). We conclude that SRX biochemistry is measurable in human skeletal muscle, and our data indicate that SRX depends on fiber type as classified by MHC isoform. Extension from this preliminary work would provide further understanding regarding the role of SRX in human muscle physiology.

scholarly journals Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology

2021 ◽  
Vol 12 ◽  
Author(s):  
Hyun-Kyung So ◽  
Sunghee Kim ◽  
Jong-Sun Kang ◽  
Sang-Jin Lee
Keyword(s):  
Skeletal Muscle ◽  
Chronic Inflammation ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Current Knowledge ◽  
Arginine Methylation ◽  
Muscle Physiology ◽  
Post Translational Modification ◽  
Protein Arginine Methyltransferases

Arginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes. PRMTs appear to be critical regulators in skeletal muscle physiology, including regeneration, metabolic homeostasis, and plasticity. Chronic inflammation is commonly associated with the decline of skeletal muscle mass and strength related to aging or chronic diseases, defined as sarcopenia. In turn, declined skeletal muscle mass and strength can exacerbate chronic inflammation. Thus, understanding the molecular regulatory pathway underlying the crosstalk between skeletal muscle function and inflammation might be essential for the intervention of muscle pathophysiology. In this review, we will address the current knowledge on the role of PRMTs in skeletal muscle physiology and pathophysiology with a specific emphasis on its relationship with inflammation.

scholarly journals Role of thyroid hormone in skeletal muscle physiology

2018 ◽  
Vol 236 (1) ◽  
pp. R57-R68 ◽  
Author(s):  
Flavia F Bloise ◽  
Aline Cordeiro ◽  
Tania Maria Ortiga-Carvalho
Keyword(s):  
Skeletal Muscle ◽  
Contractile Function ◽  
Muscle Physiology ◽  
Iodothyronine Deiodinases ◽  
Bioenergetic Metabolism ◽  
Proliferation And Differentiation ◽  
Health And Illness ◽  
Type 3

Thyroid hormones (TH) are crucial for development, growth, differentiation, metabolism and thermogenesis. Skeletal muscle (SM) contractile function, myogenesis and bioenergetic metabolism are influenced by TH. These effects depend on the presence of the TH transporters MCT8 and MCT10 in the plasma membrane, the expression of TH receptors (THRA or THRB) and hormone availability, which is determined either by the activation of thyroxine (T4) into triiodothyronine (T3) by type 2 iodothyronine deiodinases (D2) or by the inactivation of T4 into reverse T3 by deiodinases type 3 (D3). SM relaxation and contraction rates depend on T3 regulation of myosin expression and energy supplied by substrate oxidation in the mitochondria. The balance between D2 and D3 expression determines TH intracellular levels and thus influences the proliferation and differentiation of satellite cells, indicating an important role of TH in muscle repair and myogenesis. During critical illness, changes in TH levels and in THR and deiodinase expression negatively affect SM function and repair. This review will discuss the influence of TH action on SM contraction, bioenergetics metabolism, myogenesis and repair in health and illness conditions.

scholarly journals Choline: An Essential Nutrient for Skeletal Muscle

Nutrients ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 2144
Author(s):  
Antimo Moretti ◽  
Marco Paoletta ◽  
Sara Liguori ◽  
Matteo Bertone ◽  
Giuseppe Toro ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Scoping Review ◽  
Clinical Studies ◽  
English Language ◽  
Biological Effects ◽  
Muscle Physiology ◽  
Medical Subject Headings ◽  
Scoping Reviews

Background: Choline is an essential micronutrient with a pivotal role in several metabolic pathways contributing to liver, neurological, and hematological homeostasis. Although choline is commonly administered to improve physical performance, its effects on muscle are still unclear. The aim of this scoping review is to analyze the role of choline on skeletal muscle in terms of biological effects and clinical implications. Methods: A technical expert panel (TEP) of 6 medical specialists with expertise in muscle physiology and skeletal muscle disorders performed the review following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews) model. The TEP planned a research on PubMed selecting “choline” as MeSH (Medical Subject Headings) term adding to PubMed Search Builder the terms ”skeletal muscle” and “muscle striated”. TEP considered for eligibility articles published in the last 30 years, including original researches, particularly in vitro studies, and animal and clinical studies in the English language. Results: From the 1239 studies identified, TEP included 14 studies, 3 in vitro, 9 animal, and 2 clinical studies. Conclusions: Our scoping review elucidates and summarizes the crucial role of choline in modulating muscle fat metabolism, muscle proteins homeostasis, and the modulation of inflammation and autophagy.

scholarly journals The role of Drp1 in adult skeletal muscle physiology

2020 ◽  
Vol 598 (21) ◽  
pp. 4761-4763
Author(s):  
Valentin Dablainville ◽  
Anthony M. J. Sanchez
Keyword(s):  
Skeletal Muscle ◽  
Muscle Physiology ◽  
Adult Skeletal Muscle

scholarly journals Super-relaxed state of myosin in human skeletal muscle is fiber-type dependent

2020 ◽  
Vol 319 (6) ◽  
pp. C1158-C1162 ◽  
Author(s):  
Lien A. Phung ◽  
Aurora D. Foster ◽  
Mark S. Miller ◽  
Dawn A. Lowe ◽  
David D. Thomas
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Fiber Type ◽  
Vastus Lateralis ◽  
Epifluorescence Microscopy ◽  
Model Organisms ◽  
Muscle Physiology ◽  
Fiber Types ◽  
Mhc I

The myosin super-relaxed state (SRX) in skeletal muscle is hypothesized to play an important role in regulating muscle contractility and thermogenesis in humans but has only been examined in model organisms. Here we report the first human skeletal muscle SRX measurements, using quantitative epifluorescence microscopy of fluorescent 2′/3′- O-( N-methylanthraniloyl) ATP (mantATP) single-nucleotide turnover. Myosin heavy chain (MHC) isoform expression was determined using gel electrophoresis for each permeabilized vastus lateralis fiber, to allow for novel comparisons of SRX between fiber types. We find that the fraction of myosin in SRX is less in MHC IIA fibers than in MHC I and IIAX fibers ( P = 0.008). ATP turnover of SRX is faster in MHC IIAX fibers compared with MHC I and IIA fibers ( P = 0.001). We conclude that SRX biochemistry is measurable in human skeletal muscle, and our data indicate that SRX depends on fiber type as classified by MHC isoform. Extension from this preliminary work would provide further understanding regarding the role of SRX in human muscle physiology.

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