scholarly journals Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin

Cell Calcium ◽  
2017 ◽  
Vol 66 ◽  
pp. 62-70 ◽  
Author(s):  
Le Xu ◽  
Angela C. Gomez ◽  
Daniel A. Pasek ◽  
Gerhard Meissner ◽  
Naohiro Yamaguchi
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channels ◽  
Ef Hand ◽  
Specific Regulation

Dysfunctional ryanodine receptor calcium release channels in Alzheimer's disease

2000 ◽  
Vol 28 (1) ◽  
pp. A18-A18
Author(s):  
C. O'Neill ◽  
J. Fastbom ◽  
R. Cowburn ◽  
M. Carmody ◽  
T.G. Ohm ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channels

scholarly journals Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

2014 ◽  
Vol 114 (7) ◽  
pp. 1114-1124 ◽  
Author(s):  
Hyun Seok Hwang ◽  
Florentin R. Nitu ◽  
Yi Yang ◽  
Kafa Walweel ◽  
Laetitia Pereira ◽  
...  
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channels

Ryanodine receptor Ca2+ release channels: does diversity in form equal diversity in function?

1996 ◽  
Vol 76 (4) ◽  
pp. 1027-1071 ◽  
Author(s):  
J. L. Sutko ◽  
J. A. Airey
Keyword(s):  
Intracellular Calcium ◽  
Ryanodine Receptor ◽  
Skeletal Muscles ◽  
Calcium Release ◽  
Cell Types ◽  
Calcium Transients ◽  
Eukaryotic Cells ◽  
Calcium Release Channels ◽  
Primary Focus ◽  
Fast Twitch

Complexities in calcium signaling in eukaryotic cells require diversity in the proteins involved in generating these signals. In this review, we consider the ryanodine receptor (RyR) family of intracellular calcium release channels. This includes species, tissue, and cellular distributions of the RyRs and mechanisms of activation, deactivation, and inactivation of RyR calcium release events. In addition, as first observed in nonmammalian vertebrate skeletal muscles, it is now clear that more than one RyR isoform is frequently coexpressed within many cell types. How multiple ryanodine receptor release channels are used to generate intracellular calcium transients is unknown. Therefore, a primary focus of this review is why more than one RyR is required for this purpose, particularly in a tissue, such as vertebrate fast-twitch skeletal muscles, where a relatively simple and straightforward change in calcium would appear to be required to elicit contraction. Finally, the roles of the RyR isoforms and the calcium release events they mediate in the development of embryonic skeletal muscle are considered.

scholarly journals Exploiting Peptidomimetics to Synthesize Compounds That Activate Ryanodine Receptor Calcium Release Channels

ChemMedChem ◽  
2018 ◽  
Vol 13 (18) ◽  
pp. 1957-1971 ◽  
Author(s):  
Ken Robinson ◽  
Christopher J. Easton ◽  
Angela F. Dulhunty ◽  
Marco G. Casarotto
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channels

scholarly journals CLIC-2 Determines FKBP12 and FKBP12.6 Association with Ryanodine Receptor Calcium Release Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 124a
Author(s):  
Gregory A. Steele ◽  
Nicole A. Beard ◽  
Philip G. Board ◽  
Angela F. Dulhunty
Keyword(s):  
Ryanodine Receptor ◽  
Calcium Release ◽  
Calcium Release Channels

scholarly journals The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

1995 ◽  
Vol 128 (5) ◽  
pp. 893-904 ◽  
Author(s):  
G Giannini ◽  
A Conti ◽  
S Mammarella ◽  
M Scrobogna ◽  
V Sorrentino
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intracellular Calcium ◽  
Ryanodine Receptor ◽  
Calcium Release ◽  
Ryanodine Receptors ◽  
Calcium Release Channels ◽  
Peripheral Tissues ◽  
The Central Nervous System

Ryanodine receptors (RyRs) are intracellular calcium release channels that participate in controlling cytosolic calcium levels. At variance with the probably ubiquitous inositol 1,4,5-trisphosphate-operated calcium channels (1,4,5-trisphosphate receptors), RyRs have been mainly regarded as the calcium release channels controlling skeletal and cardiac muscle contraction. Increasing evidence has recently suggested that RyRs may be more widely expressed, but this has never been extensively examined. Therefore, we cloned three cDNAs corresponding to murine RyR homologues to carry a comprehensive analysis of their expression in murine tissues. Here, we report that the three genes are expressed in almost all tissues analyzed, where tissue-specific patterns of expression were observed. In the uterus and vas deferens, expression of RyR3 was localized to the smooth muscle component of these organs. In the testis, expression of RyR1 and RyR3 was detected in germ cells. RyR mRNAs were also detected in in vitro-cultured cell lines. RyR1, RyR2, and RyR3 mRNA were detected in the cerebrum and in the cerebellum. In situ analysis revealed a cell type-specific pattern of expression in the different regions of the central nervous system. The differential expression of the three ryanodine receptor genes in the central nervous system was also confirmed using specific antibodies against the respective proteins. This widespread pattern of expression suggests that RyRs may participate in the regulation of intracellular calcium homeostasis in a range of cells wider than previously recognized.

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