Rho kinase regulation of vasopressin-induced calcium entry in vascular smooth muscle cell: Comparison between rat isolated aorta and cultured aortic cells

Cell Calcium ◽  
2012 ◽  
Vol 52 (6) ◽  
pp. 413-421 ◽  
Author(s):  
Anneloes Martinsen ◽  
Nicolas Baeyens ◽  
Xavier Yerna ◽  
Nicole Morel
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Rho Kinase ◽  
Calcium Entry ◽  
Kinase Regulation ◽  
Isolated Aorta

scholarly journals Rho and Rho Kinase Mediate Thrombin-Stimulated Vascular Smooth Muscle Cell DNA Synthesis and Migration

1999 ◽  
Vol 84 (10) ◽  
pp. 1186-1193 ◽  
Author(s):  
Tammy M. Seasholtz ◽  
Mousumi Majumdar ◽  
Daniel D. Kaplan ◽  
Joan Heller Brown
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Dna Synthesis ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Rho Kinase ◽  
And Migration

scholarly journals Possible Involvement of Rho-Kinase in Aldosterone-Induced Vascular Smooth Muscle Cell Remodeling

2008 ◽  
Vol 31 (7) ◽  
pp. 1407-1413 ◽  
Author(s):  
Kayoko MIYATA ◽  
Hirofumi HITOMI ◽  
Peng GUO ◽  
Guo-Xing ZHANG ◽  
Shoji KIMURA ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Rho Kinase ◽  
Cell Remodeling

scholarly journals Vascular smooth muscle cell contraction and relaxation in the isolated aorta: a critical regulator of large artery compliance

2019 ◽  
Vol 7 (4) ◽  
pp. e13934 ◽  
Author(s):  
Arthur J. A. Leloup ◽  
Cor E. Van Hove ◽  
Sofie De Moudt ◽  
Guido R. Y. De Meyer ◽  
Gilles W. De Keulenaer ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Large Artery ◽  
Cell Contraction ◽  
Isolated Aorta ◽  
Contraction And Relaxation

scholarly journals Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation

2013 ◽  
Vol 100 (2) ◽  
pp. 297-306 ◽  
Author(s):  
María Rodríguez-Moyano ◽  
Ignacio Díaz ◽  
Natalia Dionisio ◽  
Xuexin Zhang ◽  
Javier Ávila-Medina ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Calcium Entry ◽  
Smooth Muscle Cell Proliferation ◽  
Urotensin Ii ◽  
Store Operated Calcium Entry

Involvement of Cyclooxygenase- and Lipoxygenase-Mediated Conversion of Arachidonic Acid in Controlling Human Vascular Smooth Muscle Cell Proliferation

1990 ◽  
Vol 63 (02) ◽  
pp. 291-297 ◽  
Author(s):  
Herm-Jan M Brinkman ◽  
Marijke F van Buul-Worteiboer ◽  
Jan A van Mourik
Keyword(s):  
Cell Proliferation ◽  
Arachidonic Acid ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Vascular Smooth Muscle Cell ◽  
Muscle Cells ◽  
Smooth Muscle Cell Proliferation

SummaryWe observed that the growth of human umbilical arterysmooth muscle cells was inhibited by the phospholipase A2 inhibitors p-bromophenacylbromide and mepacrine. Thesefindings suggest that fatty acid metabolism might be integrated in the control mechanism of vascular smooth muscle cell proliferation. To identify eicosanoids possibly involved in this process, we studied both the metabolism of arachidonic acid of these cells in more detail and the effect of certain arachidonic acid metabolites on smooth muscle cells growth. We found no evidence for the conversion of arachidonic acid via the lipoxygenase pathway. In contrast, arachidonic acid was rapidly converted via the cyclooxy-genase pathway. The following metabolites were identified: prostaglandin E2 (PGE2), 6-keto-prostaglandin F1α (6-k-PGF1α), prostaglandin F2α (PGF2α), 12-hydroxyheptadecatrienoic acid (12-HHT) and 11-hydroxyeicosatetetraenoic acid (11-HETE). PGE2 was the major metabolite detected. Arachidonic acid metabolites were only found in the culture medium, not in the cell. After synthesis, 11-HETE was cleared from the culture medium. We have previously reported that PGE2 inhibits the serum-induced [3H]-thymidine incorporation of growth-arrested human umbilical artery smooth muscle cells. Here we show that also 11-HETEexerts this inhibitory property. Thus, our data suggeststhat human umbilical artery smooth muscle cells convert arachidonic acid only via the cyclooxygenase pathway. Certain metabolites produced by this pathway, including PGE2 and 11-HETE, may inhibit vascular smooth muscle cell proliferation.

Sign in / Sign up

Export Citation Format

Share Document