Lysophospholipids modulate voltage-gated calcium channel currents in pituitary cells; effects of lipid stress

Cell Calcium ◽  
2010 ◽  
Vol 47 (6) ◽  
pp. 514-524 ◽  
Author(s):  
Galia Ben-Zeev ◽  
Michael Telias ◽  
Itzhak Nussinovitch
Keyword(s):  
Calcium Channel ◽  
Pituitary Cells ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Channel Currents

Lysophospholipids Modulate Voltage-Gated Calcium Channel Currents in Pituitary Cells; Effects of Lipid-Stress

2010 ◽  
Vol 98 (3) ◽  
pp. 15a
Author(s):  
Galia Ben-Zeev ◽  
Michael Telias ◽  
Daniel Bert ◽  
Itzhak Nussinovitch
Keyword(s):  
Calcium Channel ◽  
Pituitary Cells ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Channel Currents

Evidence for two distinct voltage-gated calcium channel currents in bovine adrenal glomerulosa cells

1987 ◽  
Vol 149 (3) ◽  
pp. 1049-1054 ◽  
Author(s):  
Hiroshi Matsunaga ◽  
Naohida Yamashita ◽  
Yoshio Maruyama ◽  
Itaru Kojima ◽  
Kiyoshi Kurokawa
Keyword(s):  
Calcium Channel ◽  
Voltage Gated ◽  
Glomerulosa Cells ◽  
Voltage Gated Calcium Channel ◽  
Channel Currents

Effects of osmotic swelling on voltage-gated calcium channel currents in rat anterior pituitary cells

2003 ◽  
Vol 285 (4) ◽  
pp. C840-C852 ◽  
Author(s):  
Shlomo Ben-Tabou De-Leon ◽  
Edna Blotnick ◽  
Itzhak Nussinovitch
Keyword(s):  
Calcium Channel ◽  
Calcium Influx ◽  
Membrane Surface ◽  
Hormone Secretion ◽  
Calcium Currents ◽  
Type I ◽  
Pituitary Cells ◽  
Voltage Gated ◽  
Channel Currents ◽  
Stimulation Of

Decrease in extracellular osmolarity ([Os]e) results in stimulation of hormone secretion from pituitary cells. Different mechanisms can account for this stimulation of hormone secretion. In this study we examined the possibility that hyposmolarity directly modulates voltage-gated calcium influx in pituitary cells. The effects of hyposmolarity on L-type ( IL) and T-type ( IT) calcium currents in pituitary cells were investigated by using two hyposmotic stimuli, moderate (18-22% decrease in [Os]e) and strong (31-32% decrease in [Os]e). Exposure to moderate hyposmotic stimuli resulted in three response types in IL (a decrease, a biphasic effect, and an increase in IL) and in increase in IT. Exposure to strong hyposmotic stimuli resulted only in increases in both IL and IT. Similarly, in intact pituitary cells (perforated patch method), exposure to either moderate or strong hyposmotic stimuli resulted only in increases in both IL and IT. Thus it appears that the main effect of decrease in [Os]e is increase in calcium channel currents. This increase was differential ( IL were more sensitive than IT) and voltage independent. In addition, we show that these hyposmotic effects cannot be explained by activation of an anionic conductance or by an increase in cell membrane surface area. In conclusion, this study shows that hyposmotic swelling of pituitary cells can directly modulate voltage-gated calcium influx. This hyposmotic modulation of IL and IT may contribute to the previously reported hyposmotic stimulation of hormone secretion. The mechanisms underlying these hyposmotic effects and their possible physiological relevance are discussed.

C31 enhances voltage-gated calcium channel currents in undifferentiated PC12 cells

2005 ◽  
Vol 382 (1-2) ◽  
pp. 102-105 ◽  
Author(s):  
Ze-Gang Ma ◽  
Jun Wang ◽  
Hong Jiang ◽  
Jun-Xia Xie ◽  
Lei Chen
Keyword(s):  
Calcium Channel ◽  
Pc12 Cells ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channel ◽  
Channel Currents
Sign in / Sign up

Export Citation Format

Share Document