scholarly journals Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction

Cell Calcium ◽  
2009 ◽  
Vol 46 (1) ◽  
pp. 18-29 ◽  
Author(s):  
Tatiana Brustovetsky ◽  
Viacheslav Li ◽  
Nickolay Brustovetsky
Keyword(s):  
Glutamate Receptors ◽  
Hippocampal Neurons ◽  
Mitochondrial Contraction ◽  
Stimulation Of ◽  
Cultured Hippocampal Neurons

scholarly journals Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons

1999 ◽  
Vol 19 (4) ◽  
pp. 1263-1272 ◽  
Author(s):  
Dmitri V. Lissin ◽  
Reed C. Carroll ◽  
Roger A. Nicoll ◽  
Robert C. Malenka ◽  
Mark von Zastrow
Keyword(s):  
Glutamate Receptors ◽  
Hippocampal Neurons ◽  
Ionotropic Glutamate Receptors ◽  
Rapid Activation ◽  
Cultured Hippocampal Neurons

Astrocyte-induced modulation of synaptic transmission

1999 ◽  
Vol 77 (9) ◽  
pp. 699-706 ◽  
Author(s):  
Alfonso Araque ◽  
Rita P Sanzgiri ◽  
Vladimir Parpura ◽  
Philip G Haydon
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Receptors ◽  
Neuronal Activity ◽  
Hippocampal Neurons ◽  
Calcium Waves ◽  
Metabotropic Glutamate ◽  
Intracellular Ca ◽  
Inward Currents ◽  
Neuronal Electrical Activity ◽  
Cultured Hippocampal Neurons

The idea that astrocytes simply provide structural and trophic support to neurons has been challenged by recent evidence demonstrating that astrocytes exhibit a form of excitability and communication based on intracellular Ca2+ variations and intercellular Ca2+ waves, which can be initiated by neuronal activity. These astrocyte Ca2+ variations have now been shown to induce glutamate-dependent Ca2+ elevations and slow inward currents in neurons. More recently, it has been demonstrated that synaptic transmission between cultured hippocampal neurons can be directly modulated by astrocytes. We have reported that astrocyte stimulation can increase the frequency of miniature synaptic currents. Furthermore, we also have demonstrated that an elevation in the intracellular Ca2+ in astrocytes induces a reduction in both excitatory and inhibitory evoked synaptic transmission through the activation of selective presynaptic metabotropic glutamate receptors.Key words: astrocyte-neuron signaling, glutamate receptors, calcium waves, neuronal electrical activity, synaptic transmission.

scholarly journals Ps in the (Channel) Pod Are Not Alike …

2007 ◽  
Vol 7 (5) ◽  
pp. 136-137
Author(s):  
Yoav Noam ◽  
Tallie Z. Baram
Keyword(s):  
Neuronal Activity ◽  
Hippocampal Neurons ◽  
Neuronal Excitability ◽  
Phosphorylation Sites ◽  
Voltage Dependent ◽  
Activity Dependent ◽  
Stimulation Of ◽  
Cultured Hippocampal Neurons

Bidirectional Activity-Dependent Regulation of Neuronal Ion Channel Phosphorylation. Misonou H, Menegola M, Mohapatra DP, Guy LK, Park KS, Trimmer JS. J Neurosci 2006;26(52):13505–13514. Activity-dependent dephosphorylation of neuronal Kv2.1 channels yields hyperpolarizing shifts in their voltage-dependent activation and homoeostatic suppression of neuronal excitability. We recently identified 16 phosphorylation sites that modulate Kv2.1 function. Here, we show that in mammalian neurons, compared with other regulated sites, such as serine (S)563, phosphorylation at S603 is supersensitive to calcineurin-mediated dephosphorylation in response to kainate-induced seizures in vivo, and brief glutamate stimulation of cultured hippocampal neurons. In vitro calcineurin digestion shows that supersensitivity of S603 dephosphorylation is an inherent property of Kv2.1. Conversely, suppression of neuronal activity by anesthetic in vivo causes hyperphosphorylation at S603 but not S563. Distinct regulation of individual phosphorylation sites allows for graded and bidirectional homeostatic regulation of Kv2.1 function. S603 phosphorylation represents a sensitive bidirectional biosensor of neuronal activity.

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