scholarly journals Planar cell polarity: global inputs establishing cellular asymmetry

2017 ◽  
Vol 44 ◽  
pp. 110-116 ◽  
Author(s):  
Wen Yih Aw ◽  
Danelle Devenport
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Cellular Asymmetry

scholarly journals Coupling Planar Cell Polarity Signaling to Morphogenesis

2002 ◽  
Vol 2 ◽  
pp. 434-454 ◽  
Author(s):  
Jeffrey D. Axelrod ◽  
Helen McNeill
Keyword(s):  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Fruit Fly ◽  
Convergent Extension ◽  
Cytoskeletal Reorganization ◽  
Directional Information ◽  
Cochlear Hair Cell ◽  
Cellular Asymmetry ◽  
Pcp Signaling ◽  
Unknown Signal

Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymmetry. Most of what is known about PCP derives from studies in the fruit fly,Drosophila. We review what is known about how cells translate an unknown signal into asymmetric cytoskeletal reorganization. We then discuss how the vertebrate processes of convergent extension and cochlear hair-cell development may relate toDrosophilaPCP signaling.

scholarly journals Mathematical Modeling of Sub-Cellular Asymmetry of Fat-Dachsous Heterodimer for Generation of Planar Cell Polarity

PLoS ONE ◽  
2014 ◽  
Vol 9 (5) ◽  
pp. e97641 ◽  
Author(s):  
Mohit Kumar Jolly ◽  
Mohd Suhail Rizvi ◽  
Amit Kumar ◽  
Pradip Sinha
Keyword(s):  
Mathematical Modeling ◽  
Cell Polarity ◽  
Planar Cell Polarity ◽  
Cellular Asymmetry
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