scholarly journals Single cell pattern formation and transient cytoskeletal arrays

2014 ◽  
Vol 26 ◽  
pp. 51-59 ◽  
Author(s):  
William M Bement ◽  
George von Dassow
Keyword(s):  
Pattern Formation ◽  
Single Cell ◽  
Cell Pattern

The Multiple Faces of Carcinoid Tumor: Performance Characteristics of Low-Grade Neuroendocrine Carcinoma Metastatic to the Liver in an Educational Interlaboratory Slide Comparison Program

2011 ◽  
Vol 135 (3) ◽  
pp. 354-360
Author(s):  
Amy C Clayton ◽  
Patricia G Wasserman ◽  
Rhona J Souers ◽  
Beth Anne Chmara ◽  
Andrew Renshaw ◽  
...  
Keyword(s):  
Single Cell ◽  
Neuroendocrine Carcinoma ◽  
Benign Neoplasm ◽  
Poor Performance ◽  
Specific Reference ◽  
Low Grade ◽  
Cell Pattern ◽  
Not Otherwise Specified ◽  
Glass Slides ◽  
Large Clusters

Abstract Context.—Cytologic features of low-grade neuroendocrine carcinoma are well described in primary sites. There are fewer reports of the cytologic features specific to metastatic liver lesions or the frequency of misdiagnosis. Objective.—To identify discriminating cytologic features and characterize the rate of misdiagnosis of low-grade neuroendocrine tumors metastatic to the liver in an educational interlaboratory slide comparison program. Design.—Glass slides with the specific reference diagnosis of metastatic low-grade neuroendocrine tumor involving liver were circulated to 175 laboratories, with 575 participant responses in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Eight specific cytologic features were assessed to identify predictors of poor performance (>10% misdiagnosis). Results.—There was an exact match diagnosis in 496 of 575 responses (86%); 555 of 575 responses (96.5%) were correctly identified as malignant. Incorrect responses included adenocarcinoma (27), hepatocellular neoplasm (21), small cell carcinoma (11), benign neoplasm not otherwise specified (6), benign liver (3) and inflammation (3). Three features were significantly associated with the misdiagnosis of adenocarcinoma: presence of large clusters (P  =  .02), lack of single-cell pattern (P  =  .02), and lack of stripped nuclei (P  =  .01). Conclusion.—Participants often recognize metastatic low-grade neuroendocrine carcinoma in an educational glass-slide program. Adenocarcinoma was the most common incorrect diagnosis, especially in the presence of large cellular clusters or absence of a single-cell pattern or stripped nuclei.

scholarly journals The cytomorphologic spectrum of small-cell carcinoma and large-cell neuroendocrine carcinoma in body cavity effusions: A study of 68 cases

CytoJournal ◽  
2011 ◽  
Vol 8 ◽  
pp. 18 ◽  
Author(s):  
Walid E. Khalbuss ◽  
Huaitao Yang ◽  
Qian Lian ◽  
Abdelmonem Elhosseiny ◽  
Liron Pantanowitz ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Single Cell ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Body Cavity ◽  
Small Cell ◽  
Cell Clusters ◽  
Cell Pattern ◽  
Ancillary Studies

Background: Small-cell carcinoma (SCC) and large-cell neuroendocrine carcinoma (LCNEC) are uncommon in serous body cavity effusions. The purpose of this study is to examine the cytomorphological spectrum of SCC and LCNEC in body cavity serous fluids. Materials and Methods: We have 68 cases from 53 patients who had metastatic SCC or LCNEC diagnoses. All cytology slides and the available clinical data, histological follow-up, and ancillary studies were reviewed. Results: A total of 68 cases (60 pleural, 5 peritoneal, and 3 pericardial effusions) from 53 patients with an average age of 73 years (age range 43-92 years) were reported as diagnostic or suspicious of SCC (52 cases) or LCNEC (16 cases). The primary site was lung in 56 cases, pancreas in 6 cases, and 2 cases each from cervix, colon, and the head and neck region. Of the 68 cases, 48 cases had no history of malignancy of the same type. Ancillary studies were used in 46 cases (68%) including flow cytometric studies in 5 cases. There were three predominant cytomorphological patterns observed including small-cell clusters with prominent nuclear molding (33 cases, 49%), large-cell clusters mimicking non-small-cell carcinoma (18 cases, 26%), and single-cell pattern mimicking lymphoma (17 cases, 25%). Significant apoptosis was seen in 22 cases (33%) and marked tumor cell cannibalism was seen in 11 cases (16%). Nucleoli were prominent in 16 cases (24%). The most frequent neuroendocrine markers performed were synaptophysin and chromogranin. Conclusions: The most common cytomorphologic patterns seen in body cavity effusions of SCC and LCNEC were small-cell clusters with nuclear molding. However, in 51% of the cases either a predominant single-cell pattern mimicking lymphoma or large-cell clusters mimicking non-small carcinoma were noted. In our experience, effusions were the first manifestation of disease in the majority of patients diagnosed with neuroendocrine carcinoma. Therefore, familiarity with the cytomorphological spectrum of neuroendocrine carcinomas in fluid cytology may help in rapidly establishing an accurate diagnosis and in directing appropriate management.

scholarly journals StuA is required for cell pattern formation in Aspergillus.

1992 ◽  
Vol 6 (9) ◽  
pp. 1770-1782 ◽  
Author(s):  
K Y Miller ◽  
J Wu ◽  
B L Miller
Keyword(s):  
Pattern Formation ◽  
Cell Pattern

Is pigment cell pattern formation in zebrafish a game of cops and robbers?

2014 ◽  
Vol 27 (5) ◽  
pp. 686-687 ◽  
Author(s):  
Thomas E. Woolley ◽  
Philip K. Maini ◽  
Eamonn A. Gaffney
Keyword(s):  
Pattern Formation ◽  
Pigment Cell ◽  
Cell Pattern ◽  
Cops And Robbers

Biological surface engineering: a simple system for cell pattern formation

Biomaterials ◽  
1999 ◽  
Vol 20 (13) ◽  
pp. 1213-1220 ◽  
Author(s):  
Shuguang Zhang ◽  
Lin Yan ◽  
Michael Altman ◽  
Michael Lässle ◽  
Helen Nugent ◽  
...  
Keyword(s):  
Pattern Formation ◽  
Surface Engineering ◽  
Simple System ◽  
Cell Pattern ◽  
Biological Surface
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