Cellular sterol trafficking and metabolism: spotlight on structure

2008 ◽  
Vol 20 (4) ◽  
pp. 371-377 ◽  
Author(s):  
Elina Ikonen ◽  
Maurice Jansen
Keyword(s):  
Sterol Trafficking

scholarly journals Bis(monoacylglycero)phosphate regulates oxysterol binding protein-related protein 11 dependent sterol trafficking

2019 ◽  
Vol 1864 (9) ◽  
pp. 1247-1257 ◽  
Author(s):  
Maud Arnal-Levron ◽  
Yinan Chen ◽  
Peter Greimel ◽  
Federica Calevro ◽  
Karen Gaget ◽  
...  
Keyword(s):  
Binding Protein ◽  
Related Protein ◽  
Oxysterol Binding Protein ◽  
Sterol Trafficking

Intracellular sterol trafficking

1990 ◽  
Vol 46 (6) ◽  
pp. 599-611 ◽  
Author(s):  
M. P. Reinhart
Keyword(s):  
Sterol Trafficking

Cholesterol regulation of genes involved in sterol trafficking in human THP-1 macrophages

2005 ◽  
Vol 273 (1-2) ◽  
pp. 185-191 ◽  
Author(s):  
Gemma Llaverias ◽  
Diana Lacasa ◽  
Manuel Vázquez-Carrera ◽  
Rosa M. Sánchez ◽  
Juan C. Laguna ◽  
...  
Keyword(s):  
Cholesterol Regulation ◽  
Sterol Trafficking

scholarly journals BODIPY-Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms

Traffic ◽  
2008 ◽  
Vol 9 (11) ◽  
pp. 1839-1849 ◽  
Author(s):  
Maarit Hölttä-Vuori ◽  
Riikka-Liisa Uronen ◽  
Jarmila Repakova ◽  
Emppu Salonen ◽  
Ilpo Vattulainen ◽  
...  
Keyword(s):  
Living Cells ◽  
Sterol Trafficking

Abstract 628: Efficient Excretion of Xenosterols in the Absence of Abcg5/Abcg8

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Shailendra B Patel
Keyword(s):  
Body Weight ◽  
Plant Sterols ◽  
Whole Body ◽  
Pathological Changes ◽  
Rapid Loss ◽  
Male And Female ◽  
Female Mice ◽  
Kinetics Of ◽  
Sterol Trafficking

Hypothesis: Xenosterol excretion by the mammalian body is wholly dependent on Abcg5/Abcg8 function. Methods: To test our hypothesis, we loaded Abcg8-/- mice with dietary plant sterols until they manifested biochemical (elevated plant sterols) and pathological changes (poor body weight, macrothrombocytopenia). All dietary xenosterols were eliminated from the diet and kinetics of xenosterol loss monitored over the ensuing 16 days, monitoring plasma, bile, and stool losses, as well as whole body sterol determinations. Results: After loading Abcg8-/- mice with plant sterols, plasma sitosterol levels in both male and female mice averaged 80mg/dL. Surprisingly, there was rapid loss of xenosterols from blood as well as tissues (liver, whole body), with losses of xenosterols detected in bile and feces. By day 16, stool xenosterols were almost undetectable and reflected the dramatic loss of whole body xenosterols. Conclusions: Our data refute our hypothesis. Although loss of sterolin function leads to severe xenosterolemia in both humans and mice, at least in mice, there appears to be a pathway(s) for elimination via the biliary/intestinal route. Characterization of the transporters involved may shed further light on sterol trafficking.

Npc1 is involved in sterol trafficking in the filamentous fungus Fusarium graminearum

2011 ◽  
Vol 48 (7) ◽  
pp. 725-730 ◽  
Author(s):  
Andrew Breakspear ◽  
Matias Pasquali ◽  
Karen Broz ◽  
Yanhong Dong ◽  
H. Corby Kistler
Keyword(s):  
Fusarium Graminearum ◽  
Filamentous Fungus ◽  
Sterol Trafficking

scholarly journals Kinetic imaging of NPC1L1 and sterol trafficking between plasma membrane and recycling endosomes in hepatoma cells

2008 ◽  
Vol 49 (9) ◽  
pp. 2023-2037 ◽  
Author(s):  
Nicole Hartwig Petersen ◽  
Nils J. Færgeman ◽  
Liqing Yu ◽  
Daniel Wüstner
Keyword(s):  
Plasma Membrane ◽  
Hepatoma Cells ◽  
Recycling Endosomes ◽  
Kinetic Imaging ◽  
Sterol Trafficking

scholarly journals Enhanced Stability of Non-Canonical NPC2 in the symbiosome supports coral-algal symbiosis

2018 ◽  
Author(s):  
Elizabeth A. Hambleton ◽  
Victor A.S. Jones ◽  
Ira Maegele ◽  
David K vaskoff ◽  
Timo Sachsenheimer ◽  
...  
Keyword(s):  
Low Ph ◽  
Nutrient Transfer ◽  
Cholesterol Trafficking ◽  
Pharmacological Inhibition ◽  
Algal Symbiosis ◽  
Specific Expansion ◽  
Niemann Pick ◽  
Enhanced Stability ◽  
Over Time ◽  
Sterol Trafficking

AbstractCnidarians such as reef-building corals depend upon nutrient transfer from intracellular symbionts, but the mechanisms and evolution of this process remain unknown. Homologues of the conserved cholesterol binder Niemann-Pick Type C2 (NPC2) in cnidarians are implicated in the transfer of sterol from symbionts. Here, we show that symbionts transfer bulk sterols to the host, host sterol utilization is plastic, and pharmacological inhibition of sterol trafficking disrupts symbiosis. Having undergone an anthozoan-specific expansion, “non-canonical” NPC2s respond to symbiosis and accumulate over time at the lysosomal-like organelle in which the symbiont resides (“symbiosome”). We demonstrate that both a non- and canonical Aiptasia NPC2 bind symbiont-produced sterols, yet only the non-canonical homologue exhibits increased stability at low pH. We propose that symbiotic cnidarians adapted pre-existing cholesterol-trafficking machinery to function in the highly acidic symbiosome environment, allowing corals to dominate nutrient-poor shallow tropical seas worldwide.

scholarly journals Unraveling the sterol-trafficking defect in Niemann-Pick C disease

2009 ◽  
Vol 106 (7) ◽  
pp. 2093-2094 ◽  
Author(s):  
S. L. Sturley ◽  
M. C. Patterson ◽  
P. Pentchev
Keyword(s):  
Niemann Pick ◽  
Sterol Trafficking
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