scholarly journals Comprehensive understanding of developmental origins of health and disease concepts: Early intervention to non-communicable diseases in China

2015 ◽  
Vol 1 (3) ◽  
pp. 141-144
Author(s):  
Ri-Na Su ◽  
Hui-Xia Yang
Keyword(s):  
Early Intervention ◽  
Communicable Diseases ◽  
Developmental Origins ◽  
Comprehensive Understanding ◽  
Non Communicable Diseases ◽  
Disease Concepts ◽  
Health And Disease

scholarly journals Developmental Origins of Health and Disease: Impact of environmental dust exposure in modulating microbiome and its association with non-communicable diseases

2020 ◽  
Vol 11 (6) ◽  
pp. 545-556
Author(s):  
Delicia Shu-Qin Ooi ◽  
Cheryl Pei-Ting Tan ◽  
Michelle Jia-Yu Tay ◽  
Siong Gim Ong ◽  
Elizabeth Huiwen Tham ◽  
...  
Keyword(s):  
Microbial Communities ◽  
Early Life ◽  
Human Microbiome ◽  
Communicable Diseases ◽  
Dust Exposure ◽  
Great Promise ◽  
Developmental Origins ◽  
Non Communicable Diseases ◽  
Health And Disease ◽  
The Impact

AbstractNon-communicable diseases (NCDs) including obesity, diabetes, and allergy are chronic, multi-factorial conditions that are affected by both genetic and environmental factors. Over the last decade, the microbiome has emerged as a possible contributor to the pathogenesis of NCDs. Microbiome profiles were altered in patients with NCDs, and shift in microbial communities was associated with improvement in these health conditions. Since the genetic component of these diseases cannot be altered, the ability to manipulate the microbiome holds great promise for design of novel therapies in the prevention and treatment of NCDs. Together, the Developmental Origins of Health and Disease concept and the microbial hypothesis propose that early life exposure to environmental stimuli will alter the development and composition of the human microbiome, resulting in health consequences. Recent studies indicated that the environment we are exposed to in early life is instrumental in shaping robust immune development, possibly through modulation of the human microbiome (skin, airway, and gut). Despite much research into human microbiome, the origin of their constituent microbiota remains unclear. Dust (also known as particulate matter) is a key determinant of poor air quality in the modern urban environment. It is ubiquitous and serves as a major source and reservoir of microbial communities that modulates the human microbiome, contributing to health and disease. There are evidence that reported significant associations between environmental dust and NCDs. In this review, we will focus on the impact of dust exposure in shaping the human microbiome and its possible contribution to the development of NCDs.

scholarly journals Developmental Origins of Health and Disease: A Lifecourse Approach to the Prevention of Non-Communicable Diseases

Healthcare ◽  
2017 ◽  
Vol 5 (1) ◽  
pp. 14 ◽  
Author(s):  
Janis Baird ◽  
Chandni Jacob ◽  
Mary Barker ◽  
Caroline Fall ◽  
Mark Hanson ◽  
...  
Keyword(s):  
Communicable Diseases ◽  
Developmental Origins ◽  
Non Communicable Diseases ◽  
Health And Disease

scholarly journals The mercapturomic profile of health and non-communicable diseases

2019 ◽  
Vol 8 (2) ◽  
pp. 10 ◽  
Author(s):  
Gonçalves-Dias ◽  
Morello ◽  
Semedo ◽  
Correia ◽  
Coelho ◽  
...  
Keyword(s):  
Environmental Exposure ◽  
Inflammatory Diseases ◽  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Chronic Inflammatory Diseases ◽  
Cardiometabolic Diseases ◽  
Health And Disease ◽  
Endogenous Metabolites

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

scholarly journals Low Birthweight as a Risk Factor for Non-communicable Diseases in Adults

2022 ◽  
Vol 8 ◽  
Author(s):  
Maria Eugenia Bianchi ◽  
Jaime M. Restrepo
Keyword(s):  
Risk Factor ◽  
Low Birthweight ◽  
Perinatal Death ◽  
Communicable Diseases ◽  
Renal Physiology ◽  
Intrauterine Environment ◽  
Non Communicable Diseases ◽  
Health And Disease

According to studies undertaken over the past 40 years, low birthweight (LBW) is not only a significant predictor of perinatal death and morbidity, but also increases the risk of chronic non-communicable diseases (NCDs) in adulthood. The purpose of this paper is to summarize the research on LBW as a risk factor for NCDs in adults. The Barker hypothesis was based on the finding that adults with an LBW or an unhealthy intrauterine environment, as well as a rapid catch-up, die due to NCDs. Over the last few decades, terminology such as thrifty genes, fetal programming, developmental origins of health and disease (DOHaD), and epigenetic factors have been coined. The most common NCDs include cardiovascular disease, diabetes mellitus type 2 (DMT2), hypertension (HT), dyslipidemia, proteinuria, and chronic kidney disease (CKD). Studies in mothers who experienced famine and those that solely reported birth weight as a risk factor for mortality support the concept. Although the etiology of NCD is unknown, Barry Brenner explained the notion of a low glomerular number (nGlom) in LBW children, followed by the progression to hyperfiltration as the physiopathologic etiology of HT and CKD in adults based on Guyton's renal physiology work. Autopsies of several ethnic groups have revealed anatomopathologic evidence in fetuses and adult kidneys. Because of the renal reserve, demonstrating renal function in proportion to renal volume in vivo is more difficult in adults. The greatest impact of these theories can be seen in pediatrics and obstetrics practice.

scholarly journals Strategies to reduce non-communicable diseases in the offspring: negative and positive in utero programming

2018 ◽  
Vol 9 (6) ◽  
pp. 642-652 ◽  
Author(s):  
H. Rodriguez-Caro ◽  
S. A. Williams
Keyword(s):  
Economic Cost ◽  
In Utero ◽  
Communicable Diseases ◽  
Environmental Chemicals ◽  
Non Communicable Diseases ◽  
Promising Tool ◽  
Negative Role ◽  
Health And Disease ◽  
Unhealthy Diet

AbstractNon-communicable diseases (NCDs) are a major problem as they are the leading cause of death and represent a substantial economic cost. The ‘Developmental Origins of Health and Disease Hypothesis’ proposes that adverse stimuli at different life stages can increase the predisposition to these diseases. In fact, adverse in utero programming is a major origin of these diseases due to the high malleability of embryonic development. This review provides a comprehensive analysis of the scientific literature on in utero programming and NCDs highlighting potential medical strategies to prevent these diseases based upon this programming. We fully address the concept and mechanisms involved in this programming (anatomical disruptions, epigenetic modifications and microbiota alterations). We also examine the negative role of in utero programming on the increased predisposition of NCDs in the offspring, which introduces the passive medical approach that consists of avoiding adverse stimuli including an unhealthy diet and environmental chemicals. Finally, we extensively discuss active medical approaches that target the causes of NCDs and have the potential to significantly and rapidly reduce the incidence of NCDs. These approaches can be classified as direct in utero programming modifications and personalized lifestyle pregnancy programs; they could potentially provide transgenerational NCDs protection. Active strategies against NCDs constitute a promising tool for the reduction in NCDs.

scholarly journals Exploring the role and diversity of mucins in health and disease with special insight into non-communicable diseases

2015 ◽  
Vol 32 (8) ◽  
pp. 575-613 ◽  
Author(s):  
Santosh Kumar Behera ◽  
Ardhendu Bhusan Praharaj ◽  
Budheswar Dehury ◽  
Sapna Negi
Keyword(s):  
Communicable Diseases ◽  
Non Communicable Diseases ◽  
Health And Disease ◽  
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