Serrated colorectal polyps and the serrated neoplastic pathway: Emerging concepts in colorectal carcinogenesis

2007 ◽  
Vol 13 (6) ◽  
pp. 456-466 ◽  
Author(s):  
Rhonda K. Yantiss
Keyword(s):  
Colorectal Polyps ◽  
Colorectal Carcinogenesis

Expression of IGF-1R in Colorectal Polyps and its Role in Colorectal Carcinogenesis

2011 ◽  
Vol 10 (4) ◽  
pp. 381-389 ◽  
Author(s):  
H-B. Shan ◽  
R. Zhang ◽  
Y. Li ◽  
G-L. Xu ◽  
G-Y. Luo ◽  
...  
Keyword(s):  
Colorectal Polyps ◽  
Colorectal Carcinogenesis

scholarly journals Clinicopathological study and immunohistochemical evaluation of cyclin D1 in adenomatous polyps

2021 ◽  
Vol 25 (1) ◽  
pp. 456-463
Author(s):  
Tenya Abdulhameed ◽  
Zheen Jaff ◽  
Nali Maaruf
Keyword(s):  
Cyclin D1 ◽  
Colorectal Polyp ◽  
Colorectal Polyps ◽  
Colorectal Adenomas ◽  
Adenomatous Polyps ◽  
Colorectal Carcinogenesis ◽  
Histopathological Diagnosis ◽  
Nuclear Staining ◽  
Multistep Process ◽  
Transformation Methods

Background and objective: There are many histological types of colorectal polyps. Most of these polyps are benign epithelial polyps harboring very low risks of cancerous changes. Adenomatous polyps are the most known cancer precursors. Cyclin D1 gene amplification and or overexpression occurs in many human cancers. Cyclin D1 participates potentially in the multistep process of colorectal carcinogenesis. The present study aimed to assess the clinicopathological features of colorectal polyps and evaluate the significance of immunohistochemistry expression of cyclin D1 in adenomatouse polyp as a marker for predicting malignant transformation. Methods: A total of 180 cases of colorectal polyps were collected from Rizgary teaching Hospital and some private laboratories in Erbil, Kurdistan Region, Iraq, from January 2013 to January 2018. All cases underwent polypectomy by colonoscopy for removal of the polyp. Only cases presented with a single polyp were included. The histopathological diagnosis was revised, and the polyps were divided into four subtypes; inflammatory, hyperplastic, juvenile, and adenomas. All adenoma specimens were stained using IHC technique with cyclin D1. Results: Out of the 180 cases, the results showed that 70(38.9%) were adenomatous polyps, 56(31.1%) were hyperplastic polyps,40(22.2%) were juvenile polyps, and 14(7.8%)were inflammatory polyps. Cyclin D1 nuclear staining was detected in 24 (34.2%) adenomas. Statistical significant relations between cyclin D1 expression with male gender and with high grade dysplasia were found. Conclusion: Adenoma was the most common type among colorectal polyps. Cyclin D1 was shown to be aberrantly expressed in colorectal adenomas and may play a role in the early stages of adenoma carcinoma development. Keywords: Colorectal polyp; Cyclin D1; Adenoma.

A Tale of Two Colons and Two Cancers

Swiss Surgery ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Gervaz ◽  
Bühler ◽  
Scheiwiller ◽  
Morel
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Splenic Flexure ◽  
Chromosomal Instability ◽  
Proximal Colon ◽  
Colorectal Carcinogenesis ◽  
Physiological Data ◽  
Central Hypothesis ◽  
Group Stratification

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.

4'-Geranyloxyferulic Acid-L-name prodrug inhibits inflammation-related colorectal carcinogenesis in mice

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
T Tanaka ◽  
S Genovese ◽  
T Kochi ◽  
F Epifano ◽  
L Scauri ◽  
...  
Keyword(s):  
Colorectal Carcinogenesis
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