Studies on interaction of vanadium metal complexes with bovine serum albumin - Fluoremetric and UV–visible spectrophotometric studies

2019 ◽  
Vol 20 ◽  
pp. 100203 ◽  
Author(s):  
Vani Kondaparthy ◽  
Ayub Shaik ◽  
Kunduru Bharathi Reddy ◽  
Deva Das Manwal
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Complexes ◽  
Bovine Serum ◽  
Vanadium Metal ◽  
Uv Visible

scholarly journals In vitro Interactions of Secnidazole and Its Iron (II), Copper (II) Complexes with Bovine Serum Albumin by Fluorescence Quenching Method

2020 ◽  
Vol 23 (1) ◽  
pp. 1-9
Author(s):  
Md Jamal Hossain ◽  
Md Zakir Sultan ◽  
Mohammad A Rashid ◽  
Md Ruhul Kuddus
Keyword(s):  
Bovine Serum Albumin ◽  
Transition Metal ◽  
Fluorescence Quenching ◽  
Serum Albumin ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Bovine Serum ◽  
Spectroscopic Method ◽  
Van Der Waals Interactions

The current study was designed to investigate the interactions of an antimicrobial drug secnidazole and its two transition metal complexes with bovine serum albumin (BSA). The interactions of secnidazole and its both transition metal complexes were confirmed by the extingushing of fluorescence intensity of the protein. The fluorescence quenching of BSA by the drug and its both metal complexes showed a static quenching process and the reactions followed exothermic mechanism. The fluorescence spectroscopic method was utilized to evaluate the thermodynamic parameters like change of enthalpy (ΔH), entropy (ΔS) and Gibb’s free energy (ΔG) which indicated the bindings of the antimicrobial agent and its both metal chelates were hydrogen bonding and van der Waals interactions. The binding constant and the number of binding sites were also measured by double log plot that indicated the drug or its metal complexes bound with BSA at 1:1 ratio. Bangladesh Pharmaceutical Journal 23(1): 1-9, 2020

scholarly journals Bovine Serum Albumin Metal Complexes for Mimic of SOD

2016 ◽  
Vol 128 (11) ◽  
pp. 1783-1788 ◽  
Author(s):  
GUIFANG YAN ◽  
YUFENG HE ◽  
GANG LI ◽  
YUBING XIONG ◽  
PENGFEI SONG ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Complexes ◽  
Bovine Serum

Antioxidant activity of bovine serum albumin binding amino acid Schiff-bases metal complexes

2007 ◽  
Vol 18 (11) ◽  
pp. 1416-1418 ◽  
Author(s):  
Rong Min Wang ◽  
Juan Juan Mao ◽  
Jing Feng Song ◽  
Cai Xia Huo ◽  
Yu Feng He
Keyword(s):  
Antioxidant Activity ◽  
Amino Acid ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Complexes ◽  
Schiff Bases ◽  
Bovine Serum ◽  
Albumin Binding ◽  
Bovine Serum Albumin Binding

scholarly journals Schiff base complex conjugates of bovine serum albumin as artificial metalloenzymes for eco-friendly enantioselective sulfoxidation

RSC Advances ◽  
2018 ◽  
Vol 8 (71) ◽  
pp. 40720-40730 ◽  
Author(s):  
Jie Tang ◽  
Pengfei Yao ◽  
Lina Wang ◽  
Hedong Bian ◽  
Meiyi Luo ◽  
...  
Keyword(s):  
Schiff Base ◽  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Schiff Base Complex ◽  
Docking Studies ◽  
Host Protein ◽  
Schiff Base Complexes ◽  
Uv Visible ◽  
Artificial Metalloenzymes

Artificial metalloenzymes have been prepared by non-covalent insertion of transition metal Schiff-base complexes into bovine serum albumin as the host protein and were characterized by UV-visible spectroscopy, ESI-TOF mass spectrometry and molecular docking studies.

scholarly journals Bovine serum albumin interactions with metal complexes

2014 ◽  
Vol 87 (4) ◽  
pp. 215-219 ◽  
Author(s):  
Tamara Topală ◽  
Andreea Bodoki ◽  
Luminiţa Oprean ◽  
Radu Oprean
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Metal Complexes ◽  
Bovine Serum ◽  
Biological Functions ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Serum Albumins ◽  
Pharmacological Agents ◽  
Drug Pharmacokinetics

The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions. Keywords: drug-protein interaction, coordination complex, fluorescence spectroscopy, UV-Vis absorption spectroscopy.

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