scholarly journals The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression

2018 ◽  
Vol 68 ◽  
pp. 133-145 ◽  
Author(s):  
Olivia I. Okereke ◽  
Charles F. Reynolds ◽  
David Mischoulon ◽  
Grace Chang ◽  
Nancy R. Cook ◽  
...  
Keyword(s):  
Vitamin D ◽  
Fatty Acid ◽  
Large Scale ◽  
Late Life ◽  
Omega 3 ◽  
Late Life Depression ◽  
Omega 3 Fatty Acid ◽  
Ancillary Study

scholarly journals The effects of phosphatidylserine and omega-3 fatty acid-containing supplement on late life depression

2015 ◽  
Vol 7 (1) ◽  
pp. 7-11
Author(s):  
Teruhisa Komori
Keyword(s):  
Fatty Acids ◽  
Circadian Rhythm ◽  
Fatty Acid ◽  
Salivary Cortisol ◽  
Late Life ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Late Life Depression ◽  
Omega 3 Fatty Acid ◽  
Cortisol Levels

Late life depression is often associated with a poor response to antidepressants; therefore an alternative strategy for therapy is required. Although several studies have reported that phosphatidylserine (PS) may be effective for late life depression and that omega-3 fatty acids DHA and EPA have also proven beneficial for many higher mental functions, including depression, no concrete conclusion has been reached. This study was performed to clarify the effect of PS and omega-3 fatty acid-containing supplement for late life depression by not only clinical evaluation but also salivary cortisol levels. Eighteen elderly subjects with major depression were selected for the study. In all, insufficient improvement had been obtained by antidepressant therapy for at least 6 months. The exclusion criteria from prior brain magnetic resonance images (MRI) included the presence of structural MRI findings compatible with stroke or other gross brain lesions or malformations, but not white matter hypersensitivities. They took a supplement containing PS 100 mg, DHA 119 mg and EPA 70 mg three times a day for 12 weeks. The effects of the supplement were assessed using the 17-item Hamilton depression scale (HAMD17) and the basal levels and circadian rhythm of salivary cortisol. The study adopted them as indices because: salivary cortisol levels are high in patients with depression, their circadian rhythm related to salivary cortisol is often irregular, and these symptoms are alleviated as depression improves. The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement. These subjects were divided into 10 non-responders and 8 responders. The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders. PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

scholarly journals The effects of phosphatidylserine and omega-3 fatty acid-containing supplement on late life depression

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Teruhisa Komori
Keyword(s):  
Fatty Acids ◽  
Circadian Rhythm ◽  
Fatty Acid ◽  
Salivary Cortisol ◽  
Late Life ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Late Life Depression ◽  
Omega 3 Fatty Acid ◽  
Cortisol Levels

Late life depression is often associated with a poor response to antidepressants; therefore an alternative strategy for therapy is required. Although several studies have reported that phosphatidylserine (PS) may be effective for late life depression and that omega-3 fatty acids DHA and EPA have also proven beneficial for many higher mental functions, including depression, no concrete conclusion has been reached. This study was performed to clarify the effect of PS and omega-3 fatty acid-containing supplement for late life depression by not only clinical evaluation but also salivary cortisol levels. Eighteen elderly subjects with major depression were selected for the study. In all, insufficient improvement had been obtained by antidepressant therapy for at least 6 months. The exclusion criteria from prior brain magnetic resonance images (MRI) included the presence of structural MRI findings compatible with stroke or other gross brain lesions or malformations, but not white matter hypersensitivities. They took a supplement containing PS 100 mg, DHA 119 mg and EPA 70 mg three times a day for 12 weeks. The effects of the supplement were assessed using the 17-item Hamilton depression scale (HAM-D17) and the basal levels and circadian rhythm of salivary cortisol. The study adopted them as indices because: salivary cortisol levels are high in patients with depression, their circadian rhythm related to salivary cortisol is often irregular, and these symptoms are alleviated as depression improves. The mean HAM-D17 in all subjects taking the supplement was significantly improved after 12 weeks of taking the supplement. These subjects were divided into 10 non-responders and 8 responders. The basal levels and circadian rhythm of salivary cortisol were normalized in the responders while not in non-responders. PS and omega-3 fatty acids, or other elements of the supplement, may be effective for late life depression, associated with the correction of basal levels and circadian rhythm of salivary cortisol.

scholarly journals The Effects of Omega-3 Fatty Acid on Vitamin D Activation in Hemodialysis Patients: A Pilot Study

Marine Drugs ◽  
2015 ◽  
Vol 13 (2) ◽  
pp. 741-755 ◽  
Author(s):  
Su Lee ◽  
Young Son ◽  
Seong Kim ◽  
Won An
Keyword(s):  
Vitamin D ◽  
Fatty Acid ◽  
Pilot Study ◽  
Hemodialysis Patients ◽  
Omega 3 ◽  
Omega 3 Fatty Acid

scholarly journals Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes

JAMA ◽  
2019 ◽  
Vol 322 (19) ◽  
pp. 1899 ◽  
Author(s):  
Ian H. de Boer ◽  
Leila R. Zelnick ◽  
John Ruzinski ◽  
Georgina Friedenberg ◽  
Julie Duszlak ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Fatty Acid ◽  
Kidney Function ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

SP350Modulating hepcidin levels by vitamin D and omega-3 fatty acid in 5/6 nephrectomy rat model

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
sumi lee ◽  
Nam Hyun Kyung ◽  
Son Young Ki ◽  
Kim Seong Eun ◽  
An Won Suk
Keyword(s):  
Vitamin D ◽  
Fatty Acid ◽  
Rat Model ◽  
Omega 3 ◽  
Omega 3 Fatty Acid
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