The art of building multifunctional metal-binding agents from basic molecular scaffolds for the potential application in neurodegenerative diseases

2012 ◽  
Vol 256 (19-20) ◽  
pp. 2308-2332 ◽  
Author(s):  
Cristina Rodríguez-Rodríguez ◽  
Maria Telpoukhovskaia ◽  
Chris Orvig
Keyword(s):  
Neurodegenerative Diseases ◽  
Metal Binding ◽  
Potential Application ◽  
Molecular Scaffolds ◽  
Binding Agents

scholarly journals Pharmacological activity of metal binding agents that alter copper bioavailability

2015 ◽  
Vol 44 (19) ◽  
pp. 8760-8770 ◽  
Author(s):  
Marian E. Helsel ◽  
Katherine J. Franz
Keyword(s):  
Neurodegenerative Diseases ◽  
Metal Ions ◽  
Pharmacological Activity ◽  
Metal Binding ◽  
Therapeutic Benefit ◽  
Cellular Damage ◽  
Binding Agents ◽  
Synthetic Metal ◽  
Copper Bioavailability

An exploration of synthetic metal-binding agents that alter the bioavailability of copper in ways that may provide therapeutic benefit against neurodegenerative diseases, cancer, infection, and other diseases where misappropriated metal ions are suspected of exacerbating cellular damage.

scholarly journals Neuroprotective Effect of Several Phytochemicals and Its Potential Application in the Prevention of Neurodegenerative Diseases

Geriatrics ◽  
2016 ◽  
Vol 1 (4) ◽  
pp. 29 ◽  
Author(s):  
Jintang Wang ◽  
Yuetao Song ◽  
Maolong Gao ◽  
Xujing Bai ◽  
Zheng Chen
Keyword(s):  
Neurodegenerative Diseases ◽  
Potential Application ◽  
Neuroprotective Effect

Zinc Enzymes in Crassostrea virginica

1970 ◽  
Vol 27 (1) ◽  
pp. 59-69 ◽  
Author(s):  
Douglas A. Wolfe
Keyword(s):  
Alkaline Phosphatase ◽  
Metal Binding ◽  
Zinc Enzymes ◽  
Tissue Extracts ◽  
Metabolic Functions ◽  
Binding Agents ◽  
High Molecular Weight Proteins ◽  
Cellular Components ◽  
Inhibition Studies

Nearly all the zinc in oysters is bound, either to soluble high-molecular weight proteins or to structural cellular components such as cell membranes. Oyster alkaline phosphatase is a zinc metalloenzyme, as indicated by in vitro inhibition studies with various metal-binding agents. Dialysis of soluble tissue extracts at pH 7–9 removes up to 96% of the total zinc without effect on alkaline phosphatase. If alkaline phosphatase is considered representative of the metabolic functions of zinc in oysters, most of the zinc accumulated by oysters must be superfluous to the animal's requirements.

Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases

2005 ◽  
Vol 64 (1) ◽  
pp. 120-123 ◽  
Author(s):  
M. Pallàs ◽  
E. Verdaguer ◽  
E.G. Jordà ◽  
A. Jiménez ◽  
A.M. Canudas ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Potential Application ◽  
Antitumor Drug

scholarly journals Metallacrowns: A new class of metal binding agents

1991 ◽  
Vol 43 (2-3) ◽  
pp. 148
Author(s):  
Vincent L. Pecoraro ◽  
Myoung Soo Lah ◽  
Dimitris P. Kessissoglou ◽  
Jeff Kampf ◽  
Brian Gibney
Keyword(s):  
Metal Binding ◽  
New Class ◽  
Binding Agents

In silico strategies for the selection of chelating compounds with potential application in metal-promoted neurodegenerative diseases

2010 ◽  
Vol 25 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Cristina Rodríguez-Rodríguez ◽  
Albert Rimola ◽  
Jorge Alí-Torres ◽  
Mariona Sodupe ◽  
Pilar González-Duarte
Keyword(s):  
Neurodegenerative Diseases ◽  
In Silico ◽  
Potential Application ◽  
Chelating Compounds ◽  
Selection Of

scholarly journals Phytocannabinoids: General Aspects and Pharmacological Potential in Neurodegenerative Diseases

2020 ◽  
Vol 18 ◽  
Author(s):  
Graziella dos Reis Franco ◽  
Scott Smid ◽  
Cláudio Viegas
Keyword(s):  
Drug Development ◽  
Neurodegenerative Diseases ◽  
Disease Progression ◽  
Potential Application ◽  
Neurological Diseases ◽  
Drug Candidates ◽  
Disease Modifying ◽  
Pharmacological Potential ◽  
General Aspects ◽  
State Of Art

: In the last few years research into Cannabis and its constituent phytocannabinoids has burgeoned, particularly in the potential application of novel cannabis phytochemicals for the treatment of diverse illnesses related to neurodegeneration and dementia, including Alzheimer's (AD), Parkinson's (PD) and Huntington's disease (HD). To date, these neurological diseases have mostly relied on symptomatological management. However, with an aging population globally, the search for more efficient and disease-modifying treatments that could delay or mitigate disease progression is imperative. In this context, this review aims to present a state of art in the research with cannabinoids and novel cannabinoid-based drug candidates that have been emerged as novel promising alternatives for drug development and innovation in the therapeutics of a number of diseases, especially those related to CNS-disturbance and impairment.

scholarly journals DNA-Minor Groove Binding Agents as Anti-Tubercular Probes. Old Tools for a New Challenge?

2018 ◽  
Vol 16 (2) ◽  
pp. 71-79 ◽  
Author(s):  
Federico Brucoli
Keyword(s):  
Small Molecules ◽  
Antibacterial Properties ◽  
Minor Groove ◽  
Structural Features ◽  
Minor Groove Binding ◽  
Molecular Scaffolds ◽  
Groove Binding ◽  
Dna Minor Groove ◽  
Bacterial Cell Death ◽  
Binding Agents

Tuberculosis, an ancient infectious disease caused by Mycobacterium tuberculosis, ranks as one of the top ten killers worldwide. The limited number of validated targets and scarce therapeutic options demand that renewed efforts should be made to identify tuberculosis drugs with novel mechanisms of action. To this end, mycobacterial DNA might represent a potential target for the development of effective anti-tubercular compounds. In particular, the minor groove of DNA offers an important recognition site for small-molecules that can be programmed to bind to this region in a sequence-selective manner to disrupt mycobacterial transcription factors activity and ultimately cause bacterial cell death. This review describes the structural features of the DNA-minor groove, the requirements for small molecules to bind to this site and the remarkable biophysical and antibacterial properties of DNA-minor groove binding agents, including netropsin, distamycin and their poly-heterocyclic analogues, diamidines, benzimidazole-containing molecules, duocarmycins and pyrrolo[2,1-c][1,4]benzodiazepines (PBDs). Furthermore, the ability of selected heterocyclic-polyamides and PBDs to significantly inhibit the growth of pathogenic, slow-growing M. tuberculosis and other non-pathogenic mycobacterial strains is highlighted. In summary, DNA-minor groove binding agents may serve as molecular scaffolds for the design of highly efficient probes to treat M. tuberculosis infections.

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