Structural characterization of Cu2+, Ni2+ and Zn2+ binding sites of model peptides associated with neurodegenerative diseases

2012 ◽  
Vol 256 (1-2) ◽  
pp. 352-368 ◽  
Author(s):  
Caterina Migliorini ◽  
Elena Porciatti ◽  
Marek Luczkowski ◽  
Daniela Valensin
Keyword(s):  
Neurodegenerative Diseases ◽  
Structural Characterization ◽  
Binding Sites ◽  
Model Peptides

scholarly journals Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Mohamed Azarkan ◽  
Georges Feller ◽  
Julie Vandenameele ◽  
Raphaël Herman ◽  
Rachida El Mahyaoui ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Binding Sites ◽  
Ananas Comosus ◽  
Sugar Binding ◽  
Mannose Binding

Structural characterization of β‐ketoacyl ACP synthase I bound to platencin and fragment screening molecules at two substrate binding sites

2019 ◽  
Vol 88 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Edward I. Patterson ◽  
Jeffrey D. Nanson ◽  
Jan Abendroth ◽  
Cassie Bryan ◽  
Banumathi Sankaran ◽  
...  
Keyword(s):  
Structural Characterization ◽  
Binding Sites ◽  
Substrate Binding ◽  
Fragment Screening ◽  
Substrate Binding Sites

scholarly journals Cross-π-conjugated enediyne with multitopic metal binding sites

RSC Advances ◽  
2020 ◽  
Vol 10 (63) ◽  
pp. 38612-38616
Author(s):  
Djawed Nauroozi ◽  
Benjamin Wurster ◽  
Rüdiger Faust
Keyword(s):  
Structural Characterization ◽  
Metal Binding ◽  
Binding Sites ◽  
Metal Binding Sites

Synthesis and structural characterization of a geminal enediyne molecule with three imine metal binding sites based on diazafluorenemethylidene in a cross-π-conjugated fashion is reported.

scholarly journals Amyloid-Like Aggregation in Diseases and Biomaterials: Osmosis of Structural Information

2021 ◽  
Vol 9 ◽  
Author(s):  
Nicole Balasco ◽  
Carlo Diaferia ◽  
Giancarlo Morelli ◽  
Luigi Vitagliano ◽  
Antonella Accardo
Keyword(s):  
Neurodegenerative Diseases ◽  
Structural Biology ◽  
Structural Characterization ◽  
Structural Information ◽  
Data Bank ◽  
Spectroscopic Properties ◽  
Structural Motif ◽  
Peptide Chemistry ◽  
Research Areas

The discovery that the polypeptide chain has a remarkable and intrinsic propensity to form amyloid-like aggregates endowed with an extraordinary stability is one of the most relevant breakthroughs of the last decades in both protein/peptide chemistry and structural biology. This observation has fundamental implications, as the formation of these assemblies is systematically associated with the insurgence of severe neurodegenerative diseases. Although the ability of proteins to form aggregates rich in cross-β structure has been highlighted by recent studies of structural biology, the determination of the underlying atomic models has required immense efforts and inventiveness. Interestingly, the progressive molecular and structural characterization of these assemblies has opened new perspectives in apparently unrelated fields. Indeed, the self-assembling through the cross-β structure has been exploited to generate innovative biomaterials endowed with promising mechanical and spectroscopic properties. Therefore, this structural motif has become the fil rouge connecting these diversified research areas. In the present review, we report a chronological recapitulation, also performing a survey of the structural content of the Protein Data Bank, of the milestones achieved over the years in the characterization of cross-β assemblies involved in the insurgence of neurodegenerative diseases. A particular emphasis is given to the very recent successful elucidation of amyloid-like aggregates characterized by remarkable molecular and structural complexities. We also review the state of the art of the structural characterization of cross-β based biomaterials by highlighting the benefits of the osmosis of information between these two research areas. Finally, we underline the new promising perspectives that recent successful characterizations of disease-related amyloid-like assemblies can open in the biomaterial field.

scholarly journals Biochemical and structural characterization of a thermostable Dps protein with His‐type ferroxidase centers and outer metal‐binding sites

FEBS Open Bio ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1219-1229 ◽  
Author(s):  
Takuo Minato ◽  
Takamasa Teramoto ◽  
Yoshimitsu Kakuta ◽  
Seiji Ogo ◽  
Ki‐Seok Yoon
Keyword(s):  
Structural Characterization ◽  
Metal Binding ◽  
Binding Sites ◽  
Metal Binding Sites ◽  
Dps Protein

scholarly journals Purification and Structural Characterization of Aggregation-Prone Human TDP-43 Involved in Neurodegenerative Diseases

iScience ◽  
2020 ◽  
Vol 23 (6) ◽  
pp. 101159 ◽  
Author(s):  
Gareth S.A. Wright ◽  
Tatiana F. Watanabe ◽  
Kangsa Amporndanai ◽  
Steven S. Plotkin ◽  
Neil R. Cashman ◽  
...  
Keyword(s):  
Neurodegenerative Diseases ◽  
Structural Characterization
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