A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery

2020 ◽  
Vol 31 (1) ◽  
pp. 275-280 ◽  
Author(s):  
Yueqi Wang ◽  
Changjian Li ◽  
Libo Du ◽  
Yang Liu
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Delivery ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Targeted Gene Delivery ◽  
Low Cytotoxicity

Reactive Oxygen Species (ROS)-Degradable Polymeric Nanoplatform for Hypoxia-Targeted Gene Delivery: Unpacking DNA and Reducing Toxicity

2019 ◽  
Vol 20 (5) ◽  
pp. 1899-1913 ◽  
Author(s):  
Yuxin Zhang ◽  
Jie Zhou ◽  
Shengnan Ma ◽  
Yiyan He ◽  
Jun Yang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Delivery ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Targeted Gene Delivery

scholarly journals Gene Delivery: Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery (Adv. Mater. 9/2016)

2016 ◽  
Vol 28 (9) ◽  
pp. 1714-1714 ◽  
Author(s):  
Xin Liu ◽  
Jiajia Xiang ◽  
Dingcheng Zhu ◽  
Liming Jiang ◽  
Zhuxian Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Delivery ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Charge Reversal

Serum-resistant, reactive oxygen species (ROS)-potentiated gene delivery in cancer cells mediated by fluorinated, diselenide-crosslinked polyplexes

2017 ◽  
Vol 5 (6) ◽  
pp. 1174-1182 ◽  
Author(s):  
Qiurong Deng ◽  
Xudong Li ◽  
Lipeng Zhu ◽  
Hua He ◽  
Donglai Chen ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Delivery ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Resistant Gene

Fluorinated, diselenide-crosslinked polyplexes were developed to enable ROS-responsive and serum-resistant gene delivery in cancer cells.

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

2015 ◽  
Vol 28 (9) ◽  
pp. 1743-1752 ◽  
Author(s):  
Xin Liu ◽  
Jiajia Xiang ◽  
Dingcheng Zhu ◽  
Liming Jiang ◽  
Zhuxian Zhou ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gene Delivery ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Charge Reversal

scholarly journals Enhanced Cellular Uptake and Photodynamic Effect with Amphiphilic Fluorinated Porphyrins: The Role of Sulfoester Groups and the Nature of Reactive Oxygen Species

2020 ◽  
Vol 21 (8) ◽  
pp. 2786 ◽  
Author(s):  
Barbara Pucelik ◽  
Adam Sułek ◽  
Agnieszka Drozd ◽  
Grażyna Stochel ◽  
Mariette M. Pereira ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cellular Uptake ◽  
Rational Design ◽  
Intracellular Localization ◽  
Reactive Oxygen ◽  
Type I ◽  
Oxygen Species ◽  
Photodynamic Effect ◽  
Low Cytotoxicity

A class of amphiphilic photosensitizers for photodynamic therapy (PDT) was developed. Sulfonate esters of modified porphyrins bearing—F substituents in the ortho positions of the phenyl rings have adequate properties for PDT, including absorption in the red, increased cellular uptake, favorable intracellular localization, low cytotoxicity, and high phototoxicity against A549 (human lung adenocarcinoma) and CT26 (murine colon carcinoma) cells. Moreover, the role of type I and type II photochemical processes was assessed by fluorescent probes specific for various reactive oxygen species (ROS). The photodynamic effect is improved not only by enhanced cellular uptake but also by the high generation of both singlet oxygen and oxygen-centered radicals. All of the presented results support the idea that the rational design of photosensitizers for PDT can be further improved by better understanding the determinants affecting its therapeutic efficiency and explain how smart structural modifications can make them suitable photosensitizers for application in PDT.

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