Design, synthesis and in vitro evaluation of mono (2, 2, 2-trifluoroethyl) esters, mono l-amino acid ester prodrugs of acyclic nucleoside phosphonates as anti-HBV agents

2011 ◽  
Vol 22 (12) ◽  
pp. 1387-1390 ◽  
Author(s):  
Xiao Zhong Fu ◽  
Yu Ou ◽  
Jan Xin ◽  
Yu She Yang
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Design Synthesis ◽  
In Vitro Evaluation ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Ester Prodrugs

Amino Acid Ester Prodrugs of 2-Bromo-5,6-dichloro-1-(β-d-ribofuranosyl)benzimidazole Enhance Metabolic Stability in Vitro and in Vivo

2005 ◽  
Vol 314 (2) ◽  
pp. 883-890 ◽  
Author(s):  
Philip L. Lorenzi ◽  
Christopher P. Landowski ◽  
Xueqin Song ◽  
Katherine Z. Borysko ◽  
Julie M. Breitenbach ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Metabolic Stability ◽  
Ester Prodrugs

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir

2019 ◽  
Vol 62 (7) ◽  
pp. 3553-3574 ◽  
Author(s):  
Murugaiah A. M. Subbaiah ◽  
Sandhya Mandlekar ◽  
Sridhar Desikan ◽  
Thangeswaran Ramar ◽  
Lakshumanan Subramani ◽  
...  
Keyword(s):  
Amino Acid ◽  
Protease Inhibitor ◽  
Oral Bioavailability ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Design Synthesis ◽  
Ester Prodrugs ◽  
Hiv 1 ◽  
Pharmacokinetic Evaluation

scholarly journals Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose

2021 ◽  
Vol 22 (12) ◽  
pp. 6252
Author(s):  
Paula Ossowicz-Rupniewska ◽  
Rafał Rakoczy ◽  
Anna Nowak ◽  
Maciej Konopacki ◽  
Joanna Klebeko ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Bacterial Cellulose ◽  
Acid Ester ◽  
Active Pharmaceutical Ingredient ◽  
Amino Acid Ester ◽  
Isopropyl Ester ◽  
Isopropyl Esters ◽  
Transdermal Application

The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound; therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.

Amino Acid Ester Prodrugs of the Anticancer Agent Gemcitabine:  Synthesis, Bioconversion, Metabolic Bioevasion, and hPEPT1-Mediated Transport

2005 ◽  
Vol 2 (2) ◽  
pp. 157-167 ◽  
Author(s):  
Xueqin Song ◽  
Philip L. Lorenzi ◽  
Christopher P. Landowski ◽  
Balvinder S. Vig ◽  
John M. Hilfinger ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Anticancer Agent ◽  
Amino Acid Ester ◽  
Ester Prodrugs

Synthesis of Stavudine Amino Acid Ester Prodrugs with Broad-Spectrum Chemotherapeutic Properties for the Effective Treatment of HIV/AIDS.

ChemInform ◽  
2004 ◽  
Vol 35 (26) ◽  
Author(s):  
Dharmarajan Sriram ◽  
Perumal Yogeeswari ◽  
Narasimharaghavan Srichakravarthy ◽  
Tanushree Ratan Bal
Keyword(s):  
Amino Acid ◽  
Effective Treatment ◽  
Broad Spectrum ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Ester Prodrugs ◽  
Hiv Aids

scholarly journals Design, Synthesis, and Anti-HBV Activity of New Bis(l-amino acid) Ester Tenofovir Prodrugs

2019 ◽  
Vol 10 (6) ◽  
pp. 991-995 ◽  
Author(s):  
Apeng Wang ◽  
Shuo Wu ◽  
Zeyu Tao ◽  
Xiaoning Li ◽  
Kai Lv ◽  
...  
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Design Synthesis
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