Molecular dynamics studies of the inhibitory mechanism of copper(II) on aggregation of amyloid β-peptide

2007 ◽  
Vol 18 (3) ◽  
pp. 357-360 ◽  
Author(s):  
Yong Jiao ◽  
Pin Yang
Keyword(s):  
Molecular Dynamics ◽  
Amyloid Β ◽  
Amyloid Β Peptide ◽  
Inhibitory Mechanism

Destabilization of Alzheimer’s Aβ42 protofibrils with acyclovir, carmustine, curcumin, and tetracycline: Insights from molecular dynamics simulations

2021 ◽  
Author(s):  
Ishrat Jahan ◽  
Shahid M Nayeem
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Dynamics ◽  
Neurodegenerative Diseases ◽  
Molecular Dynamics Simulations ◽  
Amyloid Β ◽  
Neural Tissue ◽  
Amyloid Β Peptide ◽  
Characteristic Symptom ◽  
Dynamics Simulations

One of the most common dementia among neurodegenerative diseases is Alzheimer’s disease (AD). The characteristic symptom of AD is the deposition and aggregation of amyloid-β-peptide in the neural tissue. A...

The inhibitory mechanism of a fullerene derivative against amyloid-β peptide aggregation: an atomistic simulation study

2016 ◽  
Vol 18 (18) ◽  
pp. 12582-12591 ◽  
Author(s):  
Yunxiang Sun ◽  
Zhenyu Qian ◽  
Guanghong Wei
Keyword(s):  
Simulation Study ◽  
Atomistic Simulation ◽  
Amyloid Β ◽  
Fullerene Derivative ◽  
Amyloid Β Peptide ◽  
Peptide Aggregation ◽  
Inhibitory Mechanism ◽  
Aβ Oligomers ◽  
Β Sheets

Fullerene inhibits the formation of inter-peptide β-sheets and β-hairpin motifs of toxic Aβ oligomers by binding to F4, Y10, L17–A21 and I31–V40 residues.

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