Prognostic value of serum thioredoxin concentrations after intracerebral hemorrhage

2016 ◽  
Vol 455 ◽  
pp. 15-19 ◽  
Author(s):  
Song-Quan Qian ◽  
Xiao-Chun Hu ◽  
Su-Rong He ◽  
Bei-Bei Li ◽  
Xu-Dong Zheng ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Prognostic Value

scholarly journals Prognostic value of elevated cardiac troponin I in patients with intracerebral hemorrhage

2019 ◽  
Vol 43 (4) ◽  
pp. 338-345
Author(s):  
Yangchun He ◽  
Qigong Liu ◽  
Jing Wang ◽  
Dao Wen Wang ◽  
Hu Ding ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Cardiac Troponin ◽  
Prognostic Value ◽  
Troponin I ◽  
Cardiac Troponin I

scholarly journals Diagnostic and prognostic value of serum hepcidin concentration in patients with acute spontaneous supratentorial intracerebral hemorrhage

2021 ◽  
Vol 23 (2) ◽  
pp. 168-174
Author(s):  
O. А. Koziolkin ◽  
A. A. Kuznietsov
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Intracerebral Hemorrhage ◽  
Logistic Regression Analysis ◽  
Prognostic Value ◽  
Cerebral Lesions ◽  
Acute Period ◽  
Serum Hepcidin ◽  
Hemorrhage Volume ◽  
Diagnostic And Prognostic Value

The aim of the study was to evaluate the diagnostic and prognostic value of serum hepcidin concentration in patients with acute spontaneous supratentorial intracerebral hemorrhage (SSICH). Materials and methods. Prospective cohort study of 88 patients with acute SSICH receiving the conservative therapy was conducted. Level of neurological deficit was evaluated using the Full Outline of UnResponsiveness Scale, the Glasgow Coma Scale and the National Institute of Health Stroke Scale. Computed tomography was performed to detect an intracerebral hemorrhage volume (ICHV), secondary intraventricular hemorrhage volume (SIVHV) and total volume of intracranial hemorrhage (TVICH). Laboratory blood samples were taken within 24 hours of hospitalization. Hepcidin levels, serum iron concentrations and total iron-binding capacity were determined, followed by calculations of transferrin saturation coefficient. Early neurological deterioration (END) and unfavorable variants of the acute period of SSICH (lethal outcome, modified Rankin score 4-5 on the 21st day of the disease) were considered as endpoints. Statistical processing of the obtained results included a correlation analysis, logistic regression analysis and ROC-analysis. Results. It was identified, that serum hepcidin level in the patients with SSICH was correlated with ICHV (R = 0.44, P ˂ 0.01), SIVHV (R = 0.45, P ˂ 0.01) and TVICH (R = 0.57, P ˂ 0.01). Hepcidin serum concentrations in the patients with ICHV >30 ml exceeded the value of those in cases of ICHV ≤30 ml by 69.0 % (P ˂ 0.0001). Serum levels of hepcidin were significantly higher in the patients with an unfavorable course and outcome of the disease in the acute period on the 1st day of admission (P ˂ 0.0001). Informative multipredictor models were developed via multiple logistic regression analysis, which include hepcidin values coupled with clinical and neurovisualization findings and are predictive of lethal and unfavorable acute period functional outcomes (AUC = 0,93, P ˂ 0.0001). Conclusions. The level of serum hepcidin in patients with acute SSICH is associated with the severity of cerebral lesions. The integration of serum hepcidin concentration with clinical and neuroimaging findings in the structure of multipredictor logistic regression models allows to determine the vital and functional prognosis of the acute period of SSICH with an accuracy of >85 %

Prognostic Value of Serum C-Reactive Protein in Spontaneous Intracerebral Hemorrhage: When Should We Take the Sample?

2017 ◽  
Vol 26 (5) ◽  
pp. 1007-1012 ◽  
Author(s):  
Youssef Zied Elhechmi ◽  
Malek Hassouna ◽  
Mohamed A. Chérif ◽  
Rym Ben Kaddour ◽  
Ines Sedghiani ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Spontaneous Intracerebral Hemorrhage ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Prognostic Value of Admission Blood Glucose in Diabetic and Non-diabetic Patients with Intracerebral Hemorrhage

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Shichao Sun ◽  
Yuesong Pan ◽  
Xingquan Zhao ◽  
Liping Liu ◽  
Hao Li ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Diabetic Patients

scholarly journals Prognostic Value of ICH Score and ICH-GS Score in Chinese Intracerebral Hemorrhage Patients: Analysis From the China National Stroke Registry (CNSR)

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77421 ◽  
Author(s):  
Wenjuan Wang ◽  
Jingjing Lu ◽  
Chunxue Wang ◽  
Yilong Wang ◽  
Hao Li ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Stroke Registry ◽  
Ich Score

scholarly journals The Prognostic Value of the Acute Phase Systemic Immune–Inflammation Index in Patients With Intracerebral Hemorrhage

2021 ◽  
Vol 12 ◽  
Author(s):  
Yunke Li ◽  
Dingke Wen ◽  
Wenyao Cui ◽  
Yuqi Chen ◽  
Fazhen Zhang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Acute Phase ◽  
Functional Outcomes ◽  
Prognostic Value ◽  
Dynamic Change ◽  
Area Under The Curve ◽  
Prognostic Index ◽  
Time Of Day ◽  
Poor Outcome ◽  
Immune Inflammation

Background and Purpose: The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH).Methods: Patients with primary spontaneous ICH were enrolled. SII was constructed based on peripheral platelet (P), neutrophil (N), and lymphocyte (L) and defined as P*N/L. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale of more than 3 at 90 days.Results: We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 h from onset. Day-1 SII had an OR in outcome (mRS >3) 1.74 (95% CI = 1.03–3.00, p = 0.04). The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 109/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03).Conclusions: SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes.

scholarly journals Prognostic value of serum S100B concentration in patients with acute spontaneous supratentorial intracerebral hemorrhage

Pathologia ◽  
2021 ◽  
Vol 18 (1) ◽  
pp. 19-25
Author(s):  
О. A. Koziolkin ◽  
A. A. Kuznietsov
Keyword(s):  
Logistic Regression ◽  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Conservative Therapy ◽  
S100b Protein ◽  
Short Term ◽  
Serum S100b ◽  
Acute Period ◽  
Protein Levels ◽  
Hemorrhage Volume

Aim of the work – to evaluate the informativeness of serum protein S100B levels in detection of short-term prognosis in patients with acute period of spontaneous supratentorial intracerebral hemorrhage (SSICH) on the background of concervative therapy. Materials and methods. Prospective cohort study of 90 patients with acute SSICH on the background of conservative therapy was done. Level of neurological deficit was evaluated using Full Outline of Unresponsiveness Scale, Glasgow Coma Scale and National Institute of Health Stroke Scale. Computed tomography was done to detect the intracerebral hemorrhage volume (ICHV), secondary intraventricular hemorrhage volume (SIVHV) and total volume of intracranial hemorrhage (TVICH). Laboratory blood samples were taken within 24 hours of hospitalization. Levels of S100B protein in serum were measured using immunoassay analysis. Unfavorable variants of course (early neurological deterioration (END) during 48 hours from hospitalization) and disease acute period outcome of ICH (modified Rankin score 4–6 on the 21st day of the disease) were considered as endpoints. Statistical processing of the obtained results included correlation analysis, logistic regression analysis and ROC-analysis. Results. Neurological deterioration during 48 hours after hospitalization was detected in 18 (20.0 %) patients, unfavorable SSICH acute period outcome was revealed in 49 (54.4 %) patients. It was detected that serum S100B protein correlates with ICHV (R = 0.34, P ˂ 0.01), SIVHV (R = 0.39, P ˂ 0.01) and TVICH (R = 0.45, P ˂ 0.01). Thus, the patients with unfavorable SSICH acute period course and outcome are characterized with the higher S100B protein levels (P ˂ 0.0001). High sensitive multipredicive logistic regression model that integrates prognostic value of serum of S100B protein concentration with informativeness of clinical, neurological parameters (National Institute of Health Stroke Scale score, SIVHV) was elaborated. It helps to detect the individual risk of unfavorable acute SSICH period outcome on the ground of conservative therapy with the accuracy 90.0 % (AUC ± SE (95 % CІ) = 0.95 ± 0.02 (0.89–0.99), P ˂ 0.0001). Conclusions. Serum S100B protein levels in patients with SSICH on the 1st day after hospitalization is the informative additional parameter in verification of short-term prognosis on the background of conservative therapy.

scholarly journals Natural History and Prognostic Value of Corticospinal Tract Wallerian Degeneration in Intracerebral Hemorrhage

2013 ◽  
Vol 2 (4) ◽  
Author(s):  
Chitra Venkatasubramanian ◽  
Jonathan T. Kleinman ◽  
Nancy J. Fischbein ◽  
Jean‐Marc Olivot ◽  
Alisa D. Gean ◽  
...  
Keyword(s):  
Natural History ◽  
Intracerebral Hemorrhage ◽  
Prognostic Value ◽  
Wallerian Degeneration ◽  
Corticospinal Tract
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