NMR metabolic profiling of serum identifies amino acid disturbances in chronic fatigue syndrome

2012 ◽  
Vol 413 (19-20) ◽  
pp. 1525-1531 ◽  
Author(s):  
Christopher W. Armstrong ◽  
Neil R. McGregor ◽  
John R. Sheedy ◽  
Ian Buttfield ◽  
Henry L. Butt ◽  
...  
Keyword(s):  
Amino Acid ◽  
Chronic Fatigue Syndrome ◽  
Metabolic Profiling ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome

JCI Insight ◽  
2016 ◽  
Vol 1 (21) ◽  
Author(s):  
Øystein Fluge ◽  
Olav Mella ◽  
Ove Bruland ◽  
Kristin Risa ◽  
Sissel E. Dyrstad ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Pyruvate Dehydrogenase ◽  
Metabolic Profiling ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

Chronic fatigue syndrome: new evidence for a central fatigue disorder

2003 ◽  
Vol 105 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Evelina GEORGIADES ◽  
Wilhelmina M. H. BEHAN ◽  
Liam P. KILDUFF ◽  
Marios HADJICHARALAMBOUS ◽  
Eileen E. MACKIE ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Chronic Fatigue Syndrome ◽  
Oxygen Uptake ◽  
Perceived Exertion ◽  
Chronic Fatigue ◽  
Rating Of Perceived Exertion ◽  
Time Points ◽  
Fatigue Syndrome ◽  
Rate Limiting

Considerable evidence points towards a prominent role for central nervous system (CNS) mechanisms in the pathogenesis of chronic fatigue syndrome (CFS), a disorder characterized chiefly by persistent, often debilitating, fatigue. We wished to characterize circulating profiles of putative amino acid modulators of CNS 5-hydroxytryptamine (5-HT; serotoninergic) and dopaminergic function in CFS patients at rest, as well as during symptom-limited exercise and subsequent recovery. Groups of 12 CFS patients and 11 age- and sex-matched sedentary controls, with similar physical activity histories, underwent ramp-incremental exercise to the limit of tolerance. Plasma amino acid concentrations, oxygen uptake and ratings of perceived exertion were measured at rest, and during exercise and recovery. Peak oxygen uptake was significantly lower in the CFS patients compared with controls. Rating of perceived exertion in the patients was higher at all time points measured, including at rest, relative to controls. Levels of free tryptophan (free Trp), the rate-limiting 5-HT precursor, were significantly higher in CFS patients at exhaustion and during recovery, whereas concentrations of branched-chain amino acids (BCAA) and large neutral amino acids (LNAA) were lower in CFS patients at exhaustion, and for LNAA also during recovery. Consequently, the [free Trp]/[BCAA] and [free Trp]/[LNAA] ratios were significantly higher in CFS patients, except at rest. On the other hand, levels of tyrosine, the rate-limiting dopaminergic precursor, were significantly lower at all time points in the CFS patients. The significant differences observed in a number of key putative CNS 5-HT and dopaminergic modulators, coupled with the exacerbated perception of effort, provide further evidence for a potentially significant role for CNS mechanisms in the pathogenesis of CFS.

scholarly journals Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

Metabolomics ◽  
2015 ◽  
Vol 11 (6) ◽  
pp. 1626-1639 ◽  
Author(s):  
Christopher W. Armstrong ◽  
Neil R. McGregor ◽  
Donald P. Lewis ◽  
Henry L. Butt ◽  
Paul R. Gooley
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Chronic Fatigue Syndrome ◽  
Metabolic Profiling ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
And Oxidative Stress

scholarly journals Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism

2017 ◽  
Vol 13 (2) ◽  
pp. 371-379 ◽  
Author(s):  
Arnaud Germain ◽  
David Ruppert ◽  
Susan M. Levine ◽  
Maureen R. Hanson
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
Chronic Fatigue Syndrome ◽  
Metabolic Profiling ◽  
Metabolic Pathways ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Discovery Cohort ◽  
Fatigue Syndrome

This work exposes disturbances in major metabolic pathways while providing a prospective path both for diagnosis and underlying ME/CFS/SEID mechanisms.

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome

Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome

2017 ◽  
Vol 33 (3) ◽  
pp. 158-165
Author(s):  
Natalia Calvo ◽  
Naia Sáez-Francàs ◽  
Sergi Valero ◽  
Jesús Castro-Marrero ◽  
José Alegre Martín ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Chronic Fatigue Syndrome ◽  
Personality Assessment ◽  
Chronic Fatigue ◽  
Specific Pattern ◽  
Harm Avoidance ◽  
Assessment Instrument ◽  
Compulsive Disorder ◽  
Fatigue Syndrome ◽  
Self Transcendence

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.

Politics, science, and the emergence of a new disease: The case of chronic fatigue syndrome.

1997 ◽  
Vol 52 (9) ◽  
pp. 973-983 ◽  
Author(s):  
Leonard A. Jason ◽  
Judith A. Richman ◽  
Fred Friedberg ◽  
Lynne Wagner ◽  
Renee Taylor ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
New Disease ◽  
Fatigue Syndrome
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