Confronting the challenge: Individualized immune monitoring after organ transplantation using the cellular immune function assay

2012 ◽  
Vol 413 (17-18) ◽  
pp. 1374-1378 ◽  
Author(s):  
Moshe Israeli ◽  
Tirza Klein ◽  
Gunnar Brandhorst ◽  
Michael Oellerich
Keyword(s):  
Immune Function ◽  
Organ Transplantation ◽  
Immune Monitoring ◽  
Cellular Immune Function ◽  
Cellular Immune

scholarly journals Marital distress prospectively predicts poorer cellular immune function

2013 ◽  
Vol 38 (11) ◽  
pp. 2713-2719 ◽  
Author(s):  
Lisa M. Jaremka ◽  
Ronald Glaser ◽  
William B. Malarkey ◽  
Janice K. Kiecolt-Glaser
Keyword(s):  
Immune Function ◽  
Marital Distress ◽  
Cellular Immune Function ◽  
Cellular Immune

scholarly journals Immunologic and clinical effects of repeated blood exchange in familial erythrophagocytic lymphohistiocytosis

Blood ◽  
1982 ◽  
Vol 60 (4) ◽  
pp. 814-821 ◽  
Author(s):  
S Ladisch ◽  
W Ho ◽  
D Matheson ◽  
R Pilkington ◽  
G Hartman
Keyword(s):  
Immune Function ◽  
Inhibitory Activity ◽  
Clinical Effects ◽  
Cellular Immune Function ◽  
Susceptibility To Infection ◽  
Blood Exchange ◽  
Cellular Immunodeficiency ◽  
Cellular Immune ◽  
Immune Defects

Depressed cellular immune function and increased susceptibility to infection characterize familial erythrophagocytic lymphohistiocytosis (FEL), a usually fatal autosomal recessive disease. One component of the immunodeficiency is plasma-mediated inhibition of lymphocyte proliferation. We have tested whether repeated plasma or blood exchange would decrease plasma inhibitory activity and improve cellular immune function in FEL. Following this treatment, reduction in plasma inhibitory activity, reversal of depressed antigen-specific lymphocyte proliferative responses and monocyte antibody-dependent cytotoxic function in vitro, and clinical improvement were complete in two and partial in one of three patients studied. Relapse, which was ultimately fatal, was associated with recurrence of the immune defects. These findings suggest that cellular immunodeficiency in FEL is acquired and possibly related to circulating immunosuppressive activity, the removal of which is associated with transient immunologic and clinical recovery.

scholarly journals Association between early parental deprivation and cellular immune function among adults in rural Fujian, China

2019 ◽  
Vol 61 (7) ◽  
pp. 1094-1099
Author(s):  
Aki Yazawa ◽  
Yosuke Inoue ◽  
Guoxi Cai ◽  
Raoping Tu ◽  
Meng Huang ◽  
...  
Keyword(s):  
Immune Function ◽  
Cellular Immune Function ◽  
Cellular Immune

scholarly journals 20-Hydroxyecdysone Primes Innate Immune Responses That Limit Bacterial and Malarial Parasite Survival in Anopheles gambiae

mSphere ◽  
2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Rebekah A. Reynolds ◽  
Hyeogsun Kwon ◽  
Ryan C. Smith
Keyword(s):  
Immune Function ◽  
Anopheles Gambiae ◽  
Blood Meal ◽  
Egg Production ◽  
Blood Feeding ◽  
Innate Immune ◽  
Content Type ◽  
Innate Immune Function ◽  
Cellular Immune Function ◽  
Cellular Immune

ABSTRACT Blood feeding is an integral behavior of mosquitoes to acquire nutritional resources needed for reproduction. This requirement also enables mosquitoes to serve as efficient vectors to acquire and potentially transmit a multitude of mosquito-borne diseases, most notably malaria. Recent studies suggest that mosquito immunity is stimulated following a blood meal, independent of infection status. Since blood feeding promotes production of the hormone 20-hydroxyecdysone (20E), we hypothesized that 20E plays an important role in priming the immune response for pathogen challenge. Here, we examine the immunological effects of priming Anopheles gambiae with 20E prior to pathogen infection, demonstrating a significant reduction in bacteria and Plasmodium berghei survival in the mosquito host. Transcriptome sequencing (RNA-seq) analysis following 20E treatment identifies several known 20E-regulated genes, as well as several immune genes with previously reported function in antipathogen defense. Together, these data demonstrate that 20E influences cellular immune function and antipathogen immunity following mosquito blood feeding, arguing the importance of hormones in the regulation of mosquito innate immune function. IMPORTANCE Blood feeding is required to provide nutrients for mosquito egg production and serves as a mechanism to acquire and transmit pathogens. Shortly after a blood meal is taken, there is a peak in the production of 20-hydroxyecdysone (20E), a mosquito hormone that initiates physiological changes, including yolk protein production and mating refractoriness. Here, we examine additional roles of 20E in the regulation of mosquito immunity, demonstrating that priming the immune system with 20E increases mosquito resistance to pathogens. We identify differentially expressed genes in response to 20E treatment, including several involved in innate immune function as well as lipid metabolism and transport. Together, these data argue that 20E stimulates mosquito cellular immune function and innate immunity shortly after blood feeding.

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