Chondrocyte of rheumatoid arthritis serve as a source of intra-articular acute-phase serum amyloid A protein

2008 ◽  
Vol 398 (1-2) ◽  
pp. 155-156 ◽  
Author(s):  
Shigeki Momohara ◽  
Hiroshi Okamoto ◽  
Hisashi Yamanaka
Keyword(s):  
Rheumatoid Arthritis ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Acute Phase Serum

The Primary Structure of Rabbit Serum Amyloid A Protein Isolated from Acute Phase Serum

1993 ◽  
Vol 37 (4) ◽  
pp. 447-451 ◽  
Author(s):  
P. V. SYVERSEN ◽  
J. JUUL ◽  
M. RYGG ◽  
K. SLETTEN ◽  
G. HUSBY ◽  
...  
Keyword(s):  
Acute Phase ◽  
Primary Structure ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Rabbit Serum ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Acute Phase Serum

A Constitutively Expressed Serum Amyloid A Protein Gene (SAA4) Is Closely Linked to, and Shares Structural Similarities with, an Acute-Phase Serum Amyloid A Protein Gene (SAA2)

Genomics ◽  
1993 ◽  
Vol 16 (2) ◽  
pp. 447-454 ◽  
Author(s):  
Diana M. Steel ◽  
Grant C. Sellar ◽  
Clarissa M. Uhlar ◽  
Susan Simon ◽  
Fred C. DeBeer ◽  
...  
Keyword(s):  
Acute Phase ◽  
Serum Amyloid A ◽  
Protein Gene ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Acute Phase Serum

scholarly journals Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study

Diabetes Care ◽  
2012 ◽  
Vol 36 (5) ◽  
pp. 1321-1326 ◽  
Author(s):  
C. Marzi ◽  
C. Huth ◽  
C. Herder ◽  
J. Baumert ◽  
B. Thorand ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Acute Phase Serum

scholarly journals Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency

1993 ◽  
Vol 291 (3) ◽  
pp. 701-707 ◽  
Author(s):  
D M Steel ◽  
J T Rogers ◽  
M C DeBeer ◽  
F C DeBeer ◽  
A S Whitehead
Keyword(s):  
Acute Phase ◽  
Time Course ◽  
Serum Amyloid A ◽  
Protein A ◽  
Serum Amyloid ◽  
Translational Efficiency ◽  
Mrna Accumulation ◽  
Amyloid A ◽  
Serum Amyloid A Protein ◽  
Acute Phase Serum

Human ‘acute-phase’ serum amyloid A protein (A-SAA) is a major acute-phase reactant (APR) and an apolipoprotein of high density lipoprotein 3 (HDL3). We have examined several parameters of A-SAA biosynthesis in PLC/PRF/5 hepatoma cells in response to monocyte conditioned medium (MoCM) and dual treatment with interleukin-1 beta and interleukin-6 (IL-1 beta + IL-6). Treatment of PLC/PRF/5 cells with MoCM or IL-1 beta + IL-6 caused a dramatic and rapid increase in A-SAA mRNA and protein synthesis; A-SAA mRNA was first detectable at 3 h, with peak levels reached by 24 h. A-SAA mRNA accumulation is accompanied by a gradual and homogeneous decrease in the length of the A-SAA poly(A) tail; the poly(A) tail shortening does not apparently affect the intrinsic stability of A-SAA mRNA. Analysis of RNA isolated from the ribonucleoprotein, monosome and polysome fractions of cytokine-treated PLC/PRF/5 cells showed that most A-SAA mRNA was associated with small polyribosomes, regardless of time post-stimulus, suggesting that the translational efficiency of A-SAA mRNA is constant throughout cytokine-driven induction. Moreover, the transit time of A-SAA protein out of the cell is also constant throughout the time course of induction. These data provide evidence of a paradox with regard to the transcriptional upregulation of A-SAA by IL-1 beta + IL-6 and the relative synthesis of A-SAA protein and suggest a role for post-transcriptional control of A-SAA biosynthesis during the acute phase.

scholarly journals Investigation of the solubility and the potentials for purification of serum amyloid A (SAA) from equine acute phase serum – a pilot study

2013 ◽  
Vol 6 (1) ◽  
Author(s):  
Michelle B Christensen ◽  
Jens Christian Sørensen ◽  
Stine Jacobsen ◽  
Mads Kjelgaard-Hansen
Keyword(s):  
Pilot Study ◽  
Acute Phase ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Acute Phase Serum
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