Primary biliary cirrhosis is not a clinical condition for increased carbohydrate-deficient transferrin: Experience with four independent CDT analysis methods

2006 ◽  
Vol 372 (1-2) ◽  
pp. 184-187 ◽  
Author(s):  
Torsten Arndt ◽  
Ursula Meier ◽  
Markus Nauck ◽  
Axel M. Gressner
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Clinical Condition ◽  
Biliary Cirrhosis ◽  
Analysis Methods ◽  
Carbohydrate Deficient Transferrin

Carbohydrate-deficient transferrin and false-positive results for alcohol abuse in primary biliary cirrhosis: differential diagnosis by detection of mitochondrial autoantibodies

1995 ◽  
Vol 41 (6) ◽  
pp. 858-861 ◽  
Author(s):  
P Bean ◽  
M S Sutphin ◽  
Y Liu ◽  
R Anton ◽  
T B Reynolds ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Alcohol Abuse ◽  
Test Performance ◽  
Roc Analysis ◽  
Biliary Cirrhosis ◽  
Antibody Testing ◽  
Serum Samples ◽  
Optimal Test ◽  
Carbohydrate Deficient Transferrin ◽  
Mitochondrial Antibody

Abstract Primary biliary cirrhosis (PBC) is one of the few nonalcohol-induced liver pathologies that causes false positives in assays of carbohydrate-deficient transferrin (CDT) for diagnosing alcohol abuse. CDT was quantified by isoelectric focusing-immunoblotting-laser densitometry (IEF-IB-LD) analysis of serum from 117 women: 57 PBC patients, 20 alcohol abusers, and 40 healthy donors. Only 5% (3 of 57) of PBC patients were positive at the densitometric cutoff value chosen (> 90% specificity). Serum samples from 15 PBC patients were further evaluated by IEF-IB-LD and CDTect chromatography-RIA. Receiver-operating characteristic (ROC) analysis showed that IEF-IB-LD better discriminated between PBC and alcohol abuse than CDTect did. By ROC analysis, mitochondrial autoantibodies to pyruvate dehydrogenase antigen M2 detected by enzyme immunoassay yielded optimal test performance for diagnosing PBC. Of six patients falsely positive for CDT by CDTect, five (83%) tested M2-positive. Thus, abnormal CDT results should be further evaluated by mitochondrial antibody testing in patients with findings compatible with PBC.

Primary biliary cirrhosis

1970 ◽  
Vol 102 (2) ◽  
pp. 228-229 ◽  
Author(s):  
A. N. Domonkos
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis

Clincal effect of long-term (32 weeks) eicosapentate administation in primary biliary cirrhosis

2001 ◽  
Vol 120 (5) ◽  
pp. A355-A355
Author(s):  
K TAKAGI ◽  
M TAKAHASHI ◽  
H TAKADA ◽  
Y KITAZUMI ◽  
T ARIMA ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Biliary Cirrhosis

Antibodies against the COOH-terminal region of E. coli ClpP protease in patients with primary biliary cirrhosis

2000 ◽  
Vol 33 (4) ◽  
pp. 528-536 ◽  
Author(s):  
Isabel Mayo ◽  
Paz Arizti ◽  
Albert Pares ◽  
Joaquin Oliva ◽  
Rita Alvarez Doforno ◽  
...  
Keyword(s):  
Primary Biliary Cirrhosis ◽  
Terminal Region ◽  
Biliary Cirrhosis ◽  
E Coli
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