Stimulation of growth hormone secretion from seabream pituitary cells in primary culture by growth hormone secretagogues is independent of growth hormone transcription

2004 ◽  
Vol 139 (1-3) ◽  
pp. 77-85 ◽  
Author(s):  
C.B. Chan ◽  
C.K. Fung ◽  
Wendy Fung ◽  
Margaret C.L. Tse ◽  
Christopher H.K. Cheng
Keyword(s):  
Growth Hormone ◽  
Primary Culture ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Pituitary Cells ◽  
Growth Hormone Secretagogues ◽  
Stimulation Of

scholarly journals Stimulation of growth hormone by kisspeptin antagonists in ewes

2018 ◽  
Vol 237 (2) ◽  
pp. 165-173 ◽  
Author(s):  
J T Smith ◽  
A Roseweir ◽  
M Millar ◽  
I J Clarke ◽  
R P Millar
Keyword(s):  
Growth Hormone ◽  
Potential Role ◽  
Third Ventricle ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Pituitary Cells ◽  
Physiological Conditions ◽  
Gh Secretion ◽  
Stimulation Of

Kisspeptin signalling is indispensable for fertility, stimulating gonadotropin-releasing hormone (GnRH) secretion and mediating gonadal steroid feedback on GnRH neurons. Moreover, kisspeptin neurons have been implicated in other non-reproductive neuroendocrine roles. Kisspeptin appears to also regulate growth hormone secretion but much of the data appear contradictory. We sought to clarify a potential role of kisspeptin in growth hormone (GH) regulation by examining the effect of kisspeptin antagonists on GH secretion in ewes under various physiological conditions. Our data show clear and robust increases in GH secretion following lateral ventricle or third ventricle infusion of kisspeptin antagonists p-234 and p-271 in either ovariectomized or anestrous ewes. Central infusion of kisspeptin-10 had no effect on GH secretion. To determine the level at which kisspeptin may influence GH secretion, we examined expression of the cognate kisspeptin receptor, GPR54, in pituitary cells and showed by immunocytochemistry that the majority of somatotropes express GPR54 while expression was largely negative in other pituitary cells. Overall, we have demonstrated that blocking kisspeptin signalling by antagonists stimulates GH secretion in ewes and that this is likely mediated by inhibiting endogenous kisspeptin activation of GPR54 expressed on somatotropes. The findings suggest that endogenous kisspeptin inhibits GH secretion through GPR54 expressed on somatotropes.

Influence of catecholamines, prostaglandins and thyroid hormones on growth hormone secretion by chicken pituitary cells in vitro

1990 ◽  
Vol 7 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Dan J. Donoghue ◽  
Frank M. Perez ◽  
Bruce S.A. Diamante ◽  
Sasha Malamed ◽  
Colin G. Scanes
Keyword(s):  
Growth Hormone ◽  
Thyroid Hormones ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Pituitary Cells

Response : Hypothalamic Stimulation of Growth Hormone Secretion

Science ◽  
1969 ◽  
Vol 163 (3868) ◽  
pp. 705-705
Author(s):  
Lawrence A. Frohman ◽  
Lee L. Bernardis ◽  
Kenneth J. Kant
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hypothalamic Stimulation ◽  
Stimulation Of

Hypothalamic Stimulation of Growth Hormone Secretion

Science ◽  
1968 ◽  
Vol 162 (3853) ◽  
pp. 580-582 ◽  
Author(s):  
L. A. Frohman ◽  
L. L. Bernardis ◽  
k. J. Kant
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Hypothalamic Stimulation ◽  
Stimulation Of
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