Thermal plasticity of the cardiorespiratory system provides cross-tolerance protection to fish exposed to elevated nitrate

2021 ◽  
Vol 240 ◽  
pp. 108920
Author(s):  
Daniel F. Gomez Isaza ◽  
Rebecca L. Cramp ◽  
Craig E. Franklin
Keyword(s):  
Cross Tolerance ◽  
Cardiorespiratory System ◽  
Thermal Plasticity

scholarly journals Acclimation to warm temperatures has important implications for mitochondrial function in Atlantic salmon (Salmo salar)

2020 ◽  
pp. jeb.236257
Author(s):  
Lucie Gerber ◽  
Kathy A. Clow ◽  
Anthony K. Gamperl
Keyword(s):  
Atlantic Salmon ◽  
Mitochondrial Function ◽  
Mitochondrial Respiration ◽  
Membrane Integrity ◽  
Respiratory Control ◽  
Acute Exposure ◽  
Ros Production ◽  
Cross Tolerance ◽  
Thermal Plasticity ◽  
And Performance

In fishes, the capacity of thermal acclimation to preserve cardiac mitochondrial function under future warming scenarios is important to understand given the central role that cardiac energy metabolism and performance play in this taxa's thermal tolerance. We acclimated Atlantic salmon to 12 and 20°C (for>2 months), and investigated the effects of acute and chronic warming on cardiac mitochondrial respiration and ROS production (release rate) using high-resolution fluorespirometry. Further, we compared the sensitivity of mitochondrial respiration to nitric oxide (i.e., the NO IC50), and assessed the mitochondrial response to anoxia-reoxygenation (AR). Acute exposure to 20°C increased maximal mitochondrial respiration by ∼55%, however, the mitochondria's complex I-respiratory control ratio was 17% lower and ROS production was increased by≥60%. Acclimation to 20°C: i) preserved mitochondrial coupling and aerobic capacity; ii) decreased the mitochondria's ROS production by ∼30%; iii) increased the mitochondria's NO IC50 by ∼23%; iv) and improved mitochondrial membrane integrity at 20°C. AR did not affect mitochondrial function at 12°C, but acute exposure to 20°C and AR depressed maximal mitochondrial respiration (by ∼9%) and coupling (by ∼16%) without impacting ROS production. Finally, warm acclimation did not improve the capacity of mitochondria to recover from AR, indicating that there was no ‘cross tolerance’ between these challenges. Our findings provide compelling evidence that thermal plasticity of cardiac mitochondrial function contributes to the Atlantic salmon's capability to survive at≥20°C for prolonged periods, but question whether this plasticity may allow them to withstand high temperatures when combined with other stressors.

Application of the ergospirometry method for physiological evaluation of the effectiveness of personal protective equipment

2020 ◽  
Vol 60 (11) ◽  
pp. 753-755
Author(s):  
Andrey M. Geregey ◽  
Evgeny S. Shuporin ◽  
Ivan V. Fateev
Keyword(s):  
Personal Protective Equipment ◽  
High Performance ◽  
Professional Activity ◽  
Protective Equipment ◽  
Cardiorespiratory System ◽  
Professional Activities ◽  
Physiological Assessment ◽  
Individual Protection ◽  
Physiological Evaluation ◽  
Field And Laboratory Conditions

Today, there are personal protective equipment, which due to their weight and size characteristics and design features can aggravate professional activity. This is characterized by an increase in the load on several major systems of the employee's body, including the cardiorespiratory system, which can cause the development of occupational pathology. The study of the functions of the cardiorespiratory system of humans in the process of his work is an important task in biomedical tests such as PPE, aggravating their professional activities and future means of individual protection from heavy labor and industrial exoskeletons. The aim of the study is to determine the possibility of using ergospirometry for the physiological assessment of personal protective equipment and industrial exoskeletons. Main part. In medical practice and high-performance sports, ergospirometry is considered the "gold standard" for functional assessment of the cardiorespiratory system. There are very few studies showing the use of ergospirometry for the purpose of physiological assessment of personal protective equipment. Results of research works in which ergospirometry was used in medicine, sports, as well as on the physiological and hygienic assessment of combat equipment, various types of personal protective equipment, including new promising personal protective equipment of the musculoskeletal system-industrial exoskeletons. The use of ergospirometry made it possible to register the main indicators of the human cardiorespiratory system both in field and laboratory conditions and allowed forming an objective conclusion about the dynamics of the degree of stress of the human cardiorespiratory system when using personal protective equipment and industrial exoskeletons with various weight and size characteristics. Thus, the use of ergospirometry both in isolation and in combination with other methods allows us to solve problems related to biomedical testing of personal protective equipment and industrial exoskeletons.

CARDIORESPIRATORY SYSTEM UNDER BICYCLE ERGOMETER TEST IN SKIERS WITH DIFFERENT TRAINING STATUS (KOMI REPUBLIC)

2019 ◽  
pp. 76-84
Author(s):  
Yu.G. Solonin ◽  
T.P. Loginova ◽  
I.O. Garnov ◽  
A.L. Markov ◽  
A.A. Chernykh ◽  
...  
Keyword(s):  
Heart Rate ◽  
Oxygen Consumption ◽  
Komi Republic ◽  
Rate Pressure Product ◽  
Training Status ◽  
Maximum Oxygen Consumption ◽  
Bicycle Ergometry ◽  
Cardiorespiratory System ◽  
Unit Pulse ◽  
Ski Racers

The aim of the study is to examine the impact of training status on ski racers (Komi Republic) at rest and under bicycle ergometry evaluating their cardiorespiratory system parameters. Materials and Methods. The authors examined male ski racers with different training status: 22 first-rank sportsmen, 22 candidates for Master of Sports and 22 Masters of Sports. Athletes underwent bicycle ergometry loads up to refusal. Oxycon Pro system (Germany) was used. Then authors studied the complex of cardiorespiratory parameters, calculating maximum oxygen consumption and unit physiological cost. Results. At rest and under standard physical load (200 W) Masters of Sports demonstrate significantly increased training status among ski racers in such cardiorespiratory system parameters as heart rate, rate pressure product and oxygen pulse. Under standard physical load (200 W) statistically significant differences between first-rank sportsmen and candidates for Master of Sports are detected by heart rate, rate pressure product, respiration rate, respiratory minute volume and oxygen utilization coefficient. Such deviations indicate differences in training status. Under maximum load, the highest training status is found in Masters of Sports: bicycle ergometry load power and duration; unit pulse, pressor and cardiac cost, bulk and unit values of maximum oxygen consumption. Heart rate values, unit pulse and heart-vent cost indicate a high training status in candidates for Master of Sports under load up to refusal, if compared with first-rank sportsmen. Athletes’ organism under load up to refusal works more efficiently than under moderate load (200 W). The training status in ski racers (Komi Republic) is manifested in the saving cardiorespiratory system functions, both at rest and under standard bicycle ergometry, as well as in parameters of unit physiological cost under loads up to refusal and increased values of maximum oxygen consumption. Keywords: ski racers, Komi Republic, training status, bicycle ergometry loads, cardiorespiratory system, maximum oxygen consumption.

Cross-Tolerance to Etorphine Differentiates μ-Opioid Agonists in a Rat Tail Withdrawal Assay

Analgesia ◽  
1998 ◽  
Vol 3 (4) ◽  
pp. 251-257 ◽  
Author(s):  
Michael J. Tiano ◽  
Ellen A. Walker ◽  
Linda A. Dykstra
Keyword(s):  
Cross Tolerance ◽  
Opioid Agonists ◽  
Rat Tail

INDICATORS OF THE RAT CARDIORESPIRATORY SYSTEM UNDER THE ACTION OF ACETYLSALICYLIC ACID AND ITS COMPLEX COMPOUNDS WITH METALS

2020 ◽  
Vol 6(72) (2) ◽  
pp. 267-280
Author(s):  
E. N. Chuyan ◽  
I. S. Mironyuk ◽  
M. Yu. Ravaeva ◽  
I. V. Cheretaev ◽  
T. V. Grishina
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Acetylsalicylic Acid ◽  
Biological Effect ◽  
Complex Compounds ◽  
Cardiorespiratory System ◽  
Animal Physiology ◽  
Scientific Equipment ◽  
Pharmaceutical Activity ◽  
Reported Study

The paper researches the effect of cobalt (АСCo2+) and zinc (АСZn2+), nickel (Ni2+) and manganese (Mn2+) acetylsalicylates in doses of 5 and 10 mg/kg on the characteristics of the rats’ cardiorespiratory system. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» of the Department of Human and Animal Physiology and Biophysics of the V. I. Vernadsky Crimean Federal University. The research of the biological effect of the acetylsalicylic acid, АСCo2+, АСZn2+ , АСNi2+, АСMn2+was carried out during their intraperitoneal injection into rats in doses of 5 mg/kg and 10 mg/kg. Simultaneously the following characteristics of all the groups’ animals were registered: heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP) and diastolic blood pressure (DBP). The pulse pressure (PP) was calculated on the basis of the SBP and DBP indices difference. BP, HR and RR of the rats were registered with the help of the system NIBP200A («BiopacSystems, Inc.», USA). The results of the current research allowed to determine that the coordinating compounds of the acetylsalicylic acid with such metals as Co, Zn, Ni2+, Mn2+ not only have more pronounced biological effect in comparison with the acetylsalicylic acid, but demonstrate new properties; the most effect on the cardiorespiratory system was achieved by АСZn2+. Thus, the results of the current research allow us to claim that the salts of the acetylsalicylates, having the metal-complexing in its molecules’ composition, have more pronounced and qualitatively new properties in comparison with the acetylsalicylic acid precursor’s properties; this makes the further search for biological and pharmaceutical activity of these coordinating compounds more perspective, as well as it makes the technology of complexingan inexpensive and highly efficient approach to the creation of new medicines. The reported study was funded by RFBR, project number 20-33-70142

Intestinal cDC1 Drive Cross-Tolerance to Epithelial-Derived Antigen Via Induction of FoxP3+CD8+ Tregs

2020 ◽  
Author(s):  
Thorsten Joeris ◽  
Cristina G. Casado ◽  
Petra Holmkvist ◽  
Simon J. Tavernier ◽  
Aaron Silva-Sanchez ◽  
...  
Keyword(s):  
Cross Tolerance

scholarly journals Cardiorespiratory Responses to 10 Weeks of Exoskeleton-Assisted Overground Walking Training inChronic Nonambulatory Patients with Spinal Cord Injury

Sensors ◽  
2021 ◽  
Vol 21 (15) ◽  
pp. 5022
Author(s):  
Jae Hyeon Park ◽  
Hyeon Seong Kim ◽  
Seong Ho Jang ◽  
Dong Jin Hyun ◽  
Sang In Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Oxygen Consumption ◽  
Exercise Intensity ◽  
Moderate Physical Activity ◽  
Intensity Level ◽  
Cardiorespiratory System ◽  
Cardiorespiratory Responses ◽  
Cord Injury ◽  
Walking Efficiency

Exercise intensity of exoskeleton-assisted walking in patients with spinal cord injury (SCI) has been reported as moderate. However, the cardiorespiratory responses to long-term exoskeleton-assisted walking have not been sufficiently investigated. We investigated the cardiorespiratory responses to 10 weeks of exoskeleton-assisted walking training in patients with SCI. Chronic nonambulatory patients with SCI were recruited from an outpatient clinic. Walking training with an exoskeleton was conducted three times per week for 10 weeks. Oxygen consumption and heart rate (HR) were measured during a 6-min walking test at pre-, mid-, and post-training. Exercise intensity was determined according to the metabolic equivalent of tasks (METs) for SCI and HR relative to the HR reserve (%HRR). Walking efficiency was calculated as oxygen consumption divided by walking speed. The exercise intensity according to the METs (both peak and average) corresponded to moderate physical activity and did not change after training. The %HRR demonstrated a moderate (peak %HRR) and light (average %HRR) exercise intensity level, and the average %HRR significantly decreased at post-training compared with mid-training (31.6 ± 8.9% to 24.3 ± 7.3%, p = 0.013). Walking efficiency progressively improved after training. Walking with an exoskeleton for 10 weeks may affect the cardiorespiratory system in chronic patients with SCI.

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