Glutathione-S-transferase alpha-4 in Hippocampus abdominalis (big-belly seahorse): Molecular characterization, antioxidant properties, and its potent immune response

2021 ◽  
Vol 240 ◽  
pp. 108917
Author(s):  
Kishanthini Nadarajapillai ◽  
D.S. Liyanage ◽  
Sarithaa Sellaththurai ◽  
Taehyug Jeong ◽  
Sukkyoung Lee ◽  
...  
Keyword(s):  
Immune Response ◽  
Molecular Characterization ◽  
Antioxidant Properties ◽  
Glutathione S Transferase ◽  
Hippocampus Abdominalis ◽  
Potent Immune Response

scholarly journals Neutralization of SARS-CoV-2 with IgG from COVID-19-convalescent plasma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kenji Maeda ◽  
Nobuyo Higashi-Kuwata ◽  
Noriko Kinoshita ◽  
Satoshi Kutsuna ◽  
Kiyoto Tsuchiya ◽  
...  
Keyword(s):  
Immune Response ◽  
Clinical Utility ◽  
Plasma Sample ◽  
Temporal Changes ◽  
Rapid Decline ◽  
Multiple Endpoints ◽  
Neutralization Activity ◽  
Neutralizing Activity ◽  
Binding Antibody ◽  
Potent Immune Response

AbstractWhile there are various attempts to administer COVID-19-convalescent plasmas to SARS-CoV-2-infected patients, neither appropriate approach nor clinical utility has been established. We examined the presence and temporal changes of the neutralizing activity of IgG fractions from 43 COVID-19-convalescent plasmas using cell-based assays with multiple endpoints. IgG fractions from 27 cases (62.8%) had significant neutralizing activity and moderately to potently inhibited SARS-CoV-2 infection in cell-based assays; however, no detectable neutralizing activity was found in 16 cases (37.2%). Approximately half of the patients (~ 41%), who had significant neutralizing activity, lost the neutralization activity within ~ 1 month. Despite the rapid decline of neutralizing activity in plasmas, good amounts of SARS-CoV-2-S1-binding antibodies were persistently seen. The longer exposure of COVID-19 patients to greater amounts of SARS-CoV-2 elicits potent immune response to SARS-CoV-2, producing greater neutralization activity and SARS-CoV-2-S1-binding antibody amounts. The dilution of highly-neutralizing plasmas with poorly-neutralizing plasmas relatively readily reduced neutralizing activity. The presence of good amounts of SARS-CoV-2-S1-binding antibodies does not serve as a surrogate ensuring the presence of good neutralizing activity. In selecting good COVID-19-convalescent plasmas, quantification of neutralizing activity in each plasma sample before collection and use is required.

Immune response of goats immunised with glutathione S-transferase and experimentally challenged with Fasciola hepatica

2010 ◽  
Vol 59 (2) ◽  
pp. 147-153 ◽  
Author(s):  
L. Buffoni ◽  
R. Zafra ◽  
A. Pérez-Écija ◽  
F.J. Martínez-Moreno ◽  
E. Martínez-Galisteo ◽  
...  
Keyword(s):  
Immune Response ◽  
Fasciola Hepatica ◽  
Glutathione S Transferase
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