Pets in peril: The relative susceptibility of cats and dogs to procoagulant snake venoms

2020 ◽  
Vol 236 ◽  
pp. 108769
Author(s):  
Christina N. Zdenek ◽  
Joshua Llinas ◽  
James Dobson ◽  
Luke Allen ◽  
Nathan Dunstan ◽  
...  
Keyword(s):  
Snake Venoms ◽  
Relative Susceptibility

A study of the major australian snake venoms in the monkey (Macaca fascicularis): I. the movement of injected venom, methods which retard this movement, and the response to antivenoms

Pathology ◽  
1981 ◽  
Vol 13 (1) ◽  
pp. 13-27 ◽  
Author(s):  
Struan K. Sutherland ◽  
A.R. Coulter ◽  
R.D. Harris ◽  
K.E. Lovering ◽  
I.D. Roberts
Keyword(s):  
Macaca Fascicularis ◽  
Snake Venoms

Biological Function and Chemistry of Endothelin. A Review

1999 ◽  
Vol 64 (8) ◽  
pp. 1211-1252 ◽  
Author(s):  
Jan Hlaváček ◽  
Renáta Marcová
Keyword(s):  
Biological Activity ◽  
Amino Acid ◽  
Biological Function ◽  
Biological Properties ◽  
Structural Basis ◽  
Amino Acid Residues ◽  
Snake Venoms ◽  
Vasoactive Peptides ◽  
Physico Chemical ◽  
Endothelin A

The first part of this review deals with the biosynthesis and a biological function of strongly vasoactive peptides named endothelins (ETs) including vasoactive intestinal contractor. Where it was useful, snake venoms sarafotoxins which are structural endothelin derivatives, were also mentioned. In the second part, an attention is paid to structural basis of the ETs biological activity, with respect to alterations of amino acid residues in the parent peptides modifying the conformation and consequently the physico-chemical and biological properties in corresponding ETs analogs. Special attention is focussed on the area of ETs receptors and their interaction with peptide and non peptide agonists and antagonists, important in designing selective inhibitors of ETs receptors potentially applicable as drugs in a medicine. A review with 182 references.

scholarly journals Phospholipase A of Snake Venoms

1971 ◽  
Vol 246 (2) ◽  
pp. 331-339 ◽  
Author(s):  
James I. Salach ◽  
Paola Turini ◽  
Richard Seng ◽  
J. Hauber ◽  
Thomas P. Singer
Keyword(s):  
Phospholipase A ◽  
Snake Venoms

Chicken egg yolk antibodies (IgY)-based antivenom for neutralization of snake venoms: a review

Toxin Reviews ◽  
2021 ◽  
pp. 1-12
Author(s):  
Ankit Choraria ◽  
Rajeswari Somasundaram ◽  
S. Janani ◽  
Selvakumar Rajendran ◽  
Naoual Oukkache ◽  
...  
Keyword(s):  
Egg Yolk ◽  
Snake Venoms ◽  
Chicken Egg ◽  
Egg Yolk Antibodies ◽  
Chicken Egg Yolk

scholarly journals A STUDY OF THE DESOXYRIBONUCLEASE ACTIVITY OF SNAKE VENOMS

1952 ◽  
Vol 195 (1) ◽  
pp. 207-213
Author(s):  
Armando R. Taborda ◽  
Laura C. Taborda ◽  
J.N. Williams ◽  
C.A. Elvehjem
Keyword(s):  
Snake Venoms

scholarly journals Pharmacological Characterisation of Pseudocerastes and Eristicophis Viper Venoms Reveal Anticancer (Melanoma) Properties and a Potentially Novel Mode of Fibrinogenolysis

2021 ◽  
Vol 22 (13) ◽  
pp. 6896
Author(s):  
Bianca op den Brouw ◽  
Parviz Ghezellou ◽  
Nicholas R. Casewell ◽  
Syed Abid Ali ◽  
Behzad Fathinia ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Serine Proteases ◽  
Human Melanoma ◽  
Snake Venoms ◽  
Lead Compounds ◽  
Bioactive Properties ◽  
Fibrinogenolytic Activity ◽  
Pharmacological Potential ◽  
Hydrolysis Of ◽  
Viper Venoms

Venoms are a rich source of potential lead compounds for drug discovery, and descriptive studies of venom form the first phase of the biodiscovery process. In this study, we investigated the pharmacological potential of crude Pseudocerastes and Eristicophis snake venoms in haematological disorders and cancer treatment. We assessed their antithrombotic potential using fibrinogen thromboelastography, fibrinogen gels with and without protease inhibitors, and colourimetric fibrinolysis assays. These assays indicated that the anticoagulant properties of the venoms are likely induced by the hydrolysis of phospholipids and by selective fibrinogenolysis. Furthermore, while most fibrinogenolysis occurred by the direct activity of snake venom metalloproteases and serine proteases, modest evidence indicated that fibrinogenolytic activity may also be mediated by selective venom phospholipases and an inhibitory venom-derived serine protease. We also found that the Pseudocerastes venoms significantly reduced the viability of human melanoma (MM96L) cells by more than 80%, while it had almost no effect on the healthy neonatal foreskin fibroblasts (NFF) as determined by viability assays. The bioactive properties of these venoms suggest that they contain a number of toxins suitable for downstream pharmacological development as candidates for antithrombotic or anticancer agents.

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