Environmental contaminants modulate transport activity of zebrafish organic anion transporters Oat1 and Oat3

2020 ◽  
Vol 231 ◽  
pp. 108742
Author(s):  
Jelena Dragojević ◽  
Petra Marić ◽  
Jovica Lončar ◽  
Marta Popović ◽  
Ivan Mihaljević ◽  
...  
Keyword(s):  
Organic Anion ◽  
Environmental Contaminants ◽  
Organic Anion Transporters ◽  
Transport Activity ◽  
Anion Transporters

scholarly journals Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1

2013 ◽  
Vol 6 ◽  
pp. IJTR.S11206 ◽  
Author(s):  
Yuichi Uwai ◽  
Hiroaki Hara ◽  
Kikuo Iwamoto
Keyword(s):  
Kynurenic Acid ◽  
Organic Anion ◽  
Species Difference ◽  
Xenopus Laevis Oocytes ◽  
Organic Anion Transporters ◽  
Comparative Experiment ◽  
Transport Activity ◽  
Estrone Sulfate ◽  
Anion Transporters ◽  
Uptake Experiment

A tryptophan catabolite, kynurenic acid, is involved in schizophrenia and uremia; there is little information on the mechanism of its disposition. Recently, our laboratory showed that kynurenic acid is a good substrate of human organic anion transporters hOAT1 and hOAT3. In this study, we performed uptake experiment using Xenopus laevis oocytes to characterize the transport of kynurenic acid by rat homologs of the transporters, rOAT1, and rOAT3. These transporters stimulated the uptake of kynurenic acid into oocytes, and transport by rOAT3 was marked. The Km values of the transport were estimated to be 8.46 μM for rOAT1 and 4.81 μM for rOAT3, and these values are comparable to their human homologs. The transport activity of kynurenic acid by rOAT1 was about one quarter of that of p-aminohippurate, although they were at the similar levels in hOAT1. A comparative experiment with hOAT1 was added in this study, showing that uptake amounts of kynurenic acid by hOAT1-expressing oocytes were 4 times greater than rOAT1-expressing oocytes. rOAT3 transported kynurenic acid as efficiently as estrone sulfate; this phenomenon was also observed in hOAT3. In conclusion, transport of kynurenic acid by rOAT1 and rOAT3 was shown. The characteristics of rOAT3 were similar to hOAT3, but low transport activity of kynurenic acid by rOAT1 was exhibited compared with hOAT1.

Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3)

2016 ◽  
Vol 468 (11-12) ◽  
pp. 1909-1918 ◽  
Author(s):  
Birgitta C. Burckhardt ◽  
Maja Henjakovic ◽  
Yohannes Hagos ◽  
Gerhard Burckhardt
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporters ◽  
Counter Flow ◽  
Anion Transporters

scholarly journals Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant Receptors

2015 ◽  
Vol 43 (12) ◽  
pp. 1855-1863 ◽  
Author(s):  
Wei Wu ◽  
Kevin T. Bush ◽  
Henry C. Liu ◽  
Christopher Zhu ◽  
Ruben Abagyan ◽  
...  
Keyword(s):  
Organic Anion ◽  
Odorant Receptors ◽  
Organic Anion Transporters ◽  
Anion Transporters

scholarly journals (−)-Epigallocatechin-3-gallate Inhibits Human and Rat Renal Organic Anion Transporters

ACS Omega ◽  
2021 ◽  
Vol 6 (6) ◽  
pp. 4347-4354
Author(s):  
Tatsuya Kawasaki ◽  
Masaki Kondo ◽  
Rioka Hiramatsu ◽  
Tomohiro Nabekura
Keyword(s):  
Organic Anion ◽  
Organic Anion Transporters ◽  
Anion Transporters

Distribution of the organic anion transporters Oat1 and Oat3 between renal membrane microdomains in obstructive jaundice

2020 ◽  
Vol 472 (6) ◽  
pp. 711-719 ◽  
Author(s):  
Evangelina Cecilia Nosetto ◽  
Romina Valeria Campagno ◽  
Adriana Mónica Torres ◽  
Anabel Brandoni
Keyword(s):  
Obstructive Jaundice ◽  
Organic Anion ◽  
Membrane Microdomains ◽  
Organic Anion Transporters ◽  
Anion Transporters
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