Zinc chloride influences embryonic development, growth, and Gh/Igf-1 gene expression during the early life stage in zebrafish (Danio rerio)

2020 ◽  
Vol 230 ◽  
pp. 108684 ◽  
Author(s):  
Yoshifumi Horie ◽  
Kei Yonekura ◽  
Ayaka Suzuki ◽  
Chiho Takahashi
Keyword(s):  
Gene Expression ◽  
Embryonic Development ◽  
Danio Rerio ◽  
Zinc Chloride ◽  
Early Life ◽  
Life Stage ◽  
Early Life Stage

Transcriptomic Responses of Bisphenol S Predict Involvement of Immune Function in the Cardiotoxicity of Early Life-Stage Zebrafish (Danio rerio)

2019 ◽  
Vol 54 (5) ◽  
pp. 2869-2877 ◽  
Author(s):  
Wenhui Qiu ◽  
Bei Chen ◽  
Justin B. Greer ◽  
Jason T. Magnuson ◽  
Ying Xiong ◽  
...  
Keyword(s):  
Immune Function ◽  
Danio Rerio ◽  
Early Life ◽  
Life Stage ◽  
Early Life Stage ◽  
Bisphenol S ◽  
Transcriptomic Responses

Early life-stage toxicity in zebrafish (Danio rerio) following embryonal exposure to selected polychlorinated biphenyls

2007 ◽  
Vol 23 (9) ◽  
pp. 529-536 ◽  
Author(s):  
T Şişman ◽  
F Geyikoğlu ◽  
M Atamanalp
Keyword(s):  
Polychlorinated Biphenyls ◽  
Danio Rerio ◽  
Early Life ◽  
Polychlorinated Biphenyl ◽  
Larval Mortality ◽  
Life Stage ◽  
Early Life Stage ◽  
Receptor Activation ◽  
Swim Bladder ◽  
Swim Bladder Inflation

Polychlorinated biphenyls are a widespread aquatic contaminant. In this article, specific polychlorinated biphenyl congeners were examined for embryo and early life-stage toxicity in zebrafish ( Danio rerio). A set of three polychlorinated biphenyl congeners (non-ortho polychlorinated biphenyl 126, mono-ortho polychlorinated biphenyl 28 and di-ortho polychlorinated biphenyl 153) were tested. The typical lesions observed were yolk sac edema, vertebra defect, craniofacial malformations (double head, triple retina), anaxial body and inhibition of swim bladder inflation. Moreover, embryo and larval mortality increased and hatching success decreased. The severity of abnormalities and mortalities were concentration- and congener-dependent. Of the compounds tested, polychlorinated biphenyl congener 126 was found to be highly toxic to the fish embryos following exposure. The Lethal Concentration 50 values for polychlorinated biphenyl 28, polychlorinated biphenyl 126, polychlorinated biphenyl 153 calculated by probit analysis were 3.270, 1.298 and 5.375 ppm, respectively. The inhibition of swim bladder inflation was the most sensitive endpoint measured, and it is suggested that the inhibition of swim bladder inflation may be mediated by mechanism with an aryl hydrocarbon receptor activation.

scholarly journals Developmental disturbances in early life stage mortality (M74) of Baltic salmon fry as studied by changes in gene expression

BMC Genomics ◽  
2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Kristiina AM Vuori ◽  
Heikki Koskinen ◽  
Aleksei Krasnov ◽  
Paula Koivumäki ◽  
Sergey Afanasyev ◽  
...  
Keyword(s):  
Gene Expression ◽  
Early Life ◽  
Life Stage ◽  
Early Life Stage ◽  
Developmental Disturbances ◽  
Salmon Fry

scholarly journals Effects of early life stage exposure of largemouth bass to atrazine or a model estrogen (17α-ethinylestradiol)

PeerJ ◽  
2020 ◽  
Vol 8 ◽  
pp. e9614
Author(s):  
Jessica K. Leet ◽  
Catherine A. Richter ◽  
Robert S. Cornman ◽  
Jason P. Berninger ◽  
Ramji K. Bhandari ◽  
...  
Keyword(s):  
Gene Expression ◽  
Early Development ◽  
Largemouth Bass ◽  
Early Life ◽  
Micropterus Salmoides ◽  
Life Stage ◽  
Early Life Stage ◽  
Smallmouth Bass ◽  
Gonad Tissue ◽  
And Function

Endocrine disrupting contaminants are of continuing concern for potentially contributing to reproductive dysfunction in largemouth and smallmouth bass in the Chesapeake Bay watershed (CBW) and elsewhere. Exposures to atrazine (ATR) have been hypothesized to have estrogenic effects on vertebrate endocrine systems. The incidence of intersex in male smallmouth bass from some regions of CBW has been correlated with ATR concentrations in water. Fish early life stages may be particularly vulnerable to ATR exposure in agricultural areas, as a spring influx of pesticides coincides with spawning and early development. Our objectives were to investigate the effects of early life stage exposure to ATR or the model estrogen 17α-ethinylestradiol (EE2) on sexual differentiation and gene expression in gonad tissue. We exposed newly hatched largemouth bass (LMB, Micropterus salmoides) from 7 to 80 days post-spawn to nominal concentrations of 1, 10, or 100 µg ATR/L or 1 or 10 ng EE2/L and monitored histological development and transcriptomic changes in gonad tissue. We observed a nearly 100% female sex ratio in LMB exposed to EE2 at 10 ng/L, presumably due to sex reversal of males. Many gonad genes were differentially expressed between sexes. Multidimensional scaling revealed clustering by gene expression of the 1 ng EE2/L and 100 µg ATR/L-treated male fish. Some pathways responsive to EE2 exposure were not sex-specific. We observed differential expression in male gonad in LMB exposed to EE2 at 1 ng/L of several genes involved in reproductive development and function, including star, cyp11a2, ddx4 (previously vasa), wnt5b, cyp1a and samhd1. Expression of star, cyp11a2 and cyp1a in males was also responsive to ATR exposure. Overall, our results confirm that early development is a sensitive window for estrogenic endocrine disruption in LMB and are consistent with the hypothesis that ATR exposure induces some estrogenic responses in the developing gonad. However, ATR-specific and EE2-specific responses were also observed.

EARLY LIFE-STAGE MORTALITY IN ZEBRAFISH (DANIO RERIO) FOLLOWING MATERNAL EXPOSURE TO POLYCHLORINATED BIPHENYLS AND ESTROGEN

2000 ◽  
Vol 19 (6) ◽  
pp. 1582 ◽  
Author(s):  
Liselotte Westerlund ◽  
Karin Billsson ◽  
Patrik L. Andersson ◽  
Mats Tysklind ◽  
Per-Erik Olsson
Keyword(s):  
Polychlorinated Biphenyls ◽  
Danio Rerio ◽  
Early Life ◽  
Life Stage ◽  
Early Life Stage ◽  
Maternal Exposure
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