Chlorpyrifos disturbs hepatic metabolism associated with oxidative stress and gut microbiota dysbiosis in adult zebrafish

2019 ◽  
Vol 216 ◽  
pp. 19-28 ◽  
Author(s):  
Xiaoyu Wang ◽  
Manlu Shen ◽  
Jiajie Zhou ◽  
Yuanxiang Jin
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Hepatic Metabolism ◽  
Adult Zebrafish ◽  
Gut Microbiota Dysbiosis

scholarly journals Microbiota Targeted Interventions of Probiotic Lactobacillus as an Anti-Ageing Approach: A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1930
Author(s):  
Muhammad Ishaq ◽  
Ashiq Khan ◽  
Ali Sher Bacha ◽  
Tariq Shah ◽  
Anum Hanif ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gut Microbiota ◽  
Therapeutic Potential ◽  
Gut Health ◽  
Core Microbiome ◽  
Targeted Interventions ◽  
Human Lifespan ◽  
Age Related ◽  
Probiotic Lactobacillus ◽  
Gut Microbiota Dysbiosis

With the implementation of modern scientific protocols, the average human lifespan has significantly improved, but age-related problems remain a challenge. With the advent of ageing, there are alterations in gut microbiota and gut barrier functions, weak immune responses, increased oxidative stress, and other age-related disorders. This review has highlighted and discussed the current understanding on the significance of gut microbiota dysbiosis and ageing and its inherent effects against age-related oxidative stress as well as on the gut health and gut-brain axis. Further, we have discussed the key mechanism of action of Lactobacillus strains in the longevity of life, alleviating gut dysbiosis, and improving oxidative stress and inflammation to provide an outline of the role of Lactobacillus strains in restoration of gut microbiota dysbiosis and alleviating certain conditions during ageing. Microbiota-targeted interventions of some characterized strains of probiotic Lactobacillus for the restoration of gut microbial community are considered as a potential approach to improve several neurological conditions. However, very limited human studies are available on this alarmed issue and recommend further studies to identify the unique Lactobacillus strains with potential anti-ageing properties and to discover its novel core microbiome-association, which will help to increase the therapeutic potential of probiotic Lactobacillus strains to ageing.

scholarly journals Protective Effects of Ellagic Acid Against Alcoholic Liver Disease in Mice

2021 ◽  
Vol 8 ◽  
Author(s):  
Liang Zhao ◽  
Arshad Mehmood ◽  
Mohamed Mohamed Soliman ◽  
Asra Iftikhar ◽  
Maryam Iftikhar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Gut Microbiota ◽  
Ellagic Acid ◽  
Antioxidant Activities ◽  
Density Lipoprotein ◽  
Dietary Therapy ◽  
Control Group ◽  
Protective Effects ◽  
Gut Microbiota Dysbiosis

Ellagic acid, a natural polyphenolic compound commonly present in vegetables, fruits, nuts, and other edible plants, exerts many pharmacological activities. The present project was designed to explore the hepatoprotective effect of ellagic acid against alcohol-induced liver disease (ALD) and the correlation among alcohol, oxidative stress, inflammation, and gut microbiota. Fifty percent (v/v) alcohol (10 mL/kg bw daily) was orally administrated for 4 weeks in mice along with ellagic acid (50 and 100 mg/kg bw). Alcohol administration significantly (p < 0.05) increased the activities of alanine aminotransferase and serum aspartate aminotransferase, levels of triglyceride, low density lipoprotein, free fatty acid, and total cholesterol, and decreased contents of the high-density lipoprotein in model group compared with the control group, which were further improved by ellagic acid (50 or 100 mg/kg bw). Furthermore, daily supplementation of ellagic acid alleviated hepatic antioxidant activities (glutathione peroxidase, catalase, malondialdehyde, superoxide dismutase, and glutathione), proinflammatory cytokines levels (IL-6, IL-1β, and TNF-α), genes expressions (Tlr4, Myd88, Cd14, Cox2, Nos2, and Nfκb1), and histopathological features in alcohol-induced liver injured mice. Additionally, results also revealed that ellagic acid supplementation improved alcohol-induced gut microbiota dysbiosis. In conclusion, ellagic acid mitigated oxidative stress, inflammatory response, steatosis, and gut microbiota dysbiosis in ALD mice. Our results suggested that ellagic acid could be applied as an ideal dietary therapy against ALD.

scholarly journals Melatonin Ameliorates Corticosterone-Mediated Oxidative Stress-Induced Colitis in Sleep-Deprived Mice Involving Gut Microbiota

2021 ◽  
Vol 2021 ◽  
pp. 1-24
Author(s):  
Ting Gao ◽  
Zixu Wang ◽  
Jing Cao ◽  
Yulan Dong ◽  
Yaoxing Chen
Keyword(s):  
Oxidative Stress ◽  
Risk Factor ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Fecal Microbiota Transplantation ◽  
Specific Treatment ◽  
Corticosterone Level ◽  
In Vitro Test ◽  
Gut Microbiota Dysbiosis

Background. Inflammatory bowel disease (IBD) is a result of a complex interplay, making development of a specific treatment a challenging task. Corticosterone was considered a risk factor of stress relative enteritis. Our previous studies found that melatonin exerts an improvement effect in sleep deprivation (SD)- induced corticosterone overproduction and colitis. A present study further explored the mechanism whereby melatonin prevented corticosterone-mediated SD-induced colitis. Methods. A 72-hour SD mouse model with or without melatonin supplementation and fecal microbiota transplantation (FMT) to investigate the core role of corticosterone in melatonin-mediated gut microbiota improving SD-induced colitis. Further, corticosterone-treated mice were assessed to the effect of melatonin on corticosterone-mediated gut microbiota dysbiosis-induced colitis. Meanwhile, an in vitro test studied modulatory mechanism of metabolite melatonin. Results. SD caused an excessive corticosterone, gut microbiota disorder and colitis phenotype. Similarly, corticosterone-supplemented mice also exhibited gut microbiota dysbiosis and colitis, and the FMT from SD-mice to normal mice could restore the SD-like colitis, but no change in the corticosterone level, which suggested that corticosterone-mediated intestinal microbiota imbalance plays a central role in SD-induced colitis. Further, we demonstrated melatonin-mediated MT2 weakened GR feedback, suppressed oxidative stress, restored the intestinal microbiota and its metabolites homeostasis, and inactivated the STAT3/AP-1/NF-κB pathway-induced inflammatory response in vivo and in vitro. Conclusions. We revealed that excessive corticosterone is a core risk factor for SD-induced colitis and provided a better understanding of the effects of melatonin, expected to be a personalized targeted therapy drug, on corticosterone-mediated gut microbiota inducing colitis.

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