scholarly journals Fluorescent light exposure incites acute and prolonged immune responses in zebrafish (Danio rerio) skin

2018 ◽  
Vol 208 ◽  
pp. 87-95 ◽  
Author(s):  
Trevor J. Gonzalez ◽  
Yuan Lu ◽  
Mikki Boswell ◽  
William Boswell ◽  
Geraldo Medrano ◽  
...  
Keyword(s):  
Immune Responses ◽  
Danio Rerio ◽  
Light Exposure ◽  
Fluorescent Light

scholarly journals Fluorescent Light Incites a Conserved Immune and Inflammatory Genetic Response within Vertebrate Organs (Danio Rerio, Oryzias Latipes and Mus Musculus)

Genes ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 271 ◽  
Author(s):  
Boswell ◽  
Lu ◽  
Boswell ◽  
Savage ◽  
Hildreth ◽  
...  
Keyword(s):  
Immune Responses ◽  
Danio Rerio ◽  
Mus Musculus ◽  
Expression Patterns ◽  
Solar Spectrum ◽  
Oryzias Latipes ◽  
Hairless Mouse ◽  
Gene Clustering ◽  
Fluorescent Light ◽  
Evolutionary Divergence

Fluorescent light (FL) has been utilized for ≈60 years and has become a common artificial light source under which animals, including humans, spend increasing amounts of time. Although the solar spectrum is quite dissimilar in both wavelengths and intensities, the genetic consequences of FL exposure have not been investigated. Herein, we present comparative RNA-Seq results that establish expression patterns within skin, brain, and liver for Danio rerio, Oryzias latipes, and the hairless mouse (Mus musculus) after exposure to FL. These animals represent diurnal and nocturnal lifestyles, and ≈450 million years of evolutionary divergence. In all three organisms, FL induced transcriptional changes of the acute phase response signaling pathway and modulated inflammation and innate immune responses. Our pathway and gene clustering analyses suggest cellular perception of oxidative stress is promoting induction of primary up-stream regulators IL1B and TNF. The skin and brain of the three animals as well as the liver of both fish models all exhibit increased inflammation and immune responses; however, the mouse liver suppressed the same pathways. Overall, the conserved nature of the genetic responses observed after FL exposure, among fishes and a mammal, suggest the presence of light responsive genetic circuitry deeply embedded in the vertebrate genome.

Effect of tributyltin on antioxidant ability and immune responses of zebrafish (Danio rerio)

2017 ◽  
Vol 138 ◽  
pp. 1-8 ◽  
Author(s):  
Chun-nuan Zhang ◽  
Ji-liang Zhang ◽  
Hong-tao Ren ◽  
Bian-hua Zhou ◽  
Qiu-jue Wu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Danio Rerio ◽  
Antioxidant Ability

Fluorescent light-Activated Flavor in Milk1

1975 ◽  
Vol 38 (7) ◽  
pp. 388-392 ◽  
Author(s):  
A. P. HANSEN ◽  
L. G. TURNER ◽  
L. W. AURAND
Keyword(s):  
Ascorbic Acid ◽  
Light Exposure ◽  
Fluorescent Light ◽  
Lighting System ◽  
Off Flavors ◽  
Flavor Development ◽  
Fluid Milk

Homogenized milk packaged in polyethylene containers exposed to fluorescent lights showed flavor and vitamin deterioration. Off-flavor development began within 2 to 4 h after exposure to a lighting system simulating commercial display cases. Detection of light-induced flavor was slight, medium, and strong after 4, 7 and 24 h of exposure. Decreases in riboflavin and ascorbic acid were directly proportional to the amount of light exposure. Various types of colored lamps and lamp filters were tested to prevent this off-flavor and vitamin degradation in milk. Yellow lamps or yellow and green filters protected milk from off-flavor development for 30 to 40 h. It is evident that light-induced off-flavors and vitamin destruction in fluid milk packaged in polyethylene containers can be reduced by colored lamps and lamp filters.

scholarly journals Quantitative Imaging and In Situ Concentration Measurements of Quantum Dot Nanomaterials in Variably Saturated Porous Media

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Burcu Uyuşur ◽  
Preston T. Snee ◽  
Chunyan Li ◽  
Christophe J. G. Darnault
Keyword(s):  
Porous Media ◽  
Quantum Dot ◽  
Light Transmission ◽  
Water Saturation ◽  
Uv Light ◽  
Light Exposure ◽  
Fluorescence Method ◽  
Fluorescent Light ◽  
Subsurface Environment

Knowledge of the fate and transport of nanoparticles in the subsurface environment is limited, as techniques to monitor and visualize the transport and distribution of nanoparticles in porous media and measure their in situ concentrations are lacking. To address these issues, we have developed a light transmission and fluorescence method to visualize and measure in situ concentrations of quantum dot (QD) nanoparticles in variably saturated environments. Calibration cells filled with sand as porous medium and various known water saturation levels and QD concentrations were prepared. By measuring the intensity of the light transmitted through porous media exposed to fluorescent light and by measuring the hue of the light emitted by the QDs under UV light exposure, we obtained simultaneously in situ measurements of water saturation and QD nanoparticle concentrations with high spatial and temporal resolutions. Water saturation was directly proportional to the light intensity. A linear relationship was observed between hue-intensity ratio values and QD concentrations for constant water saturation levels. The advantages and limitations of the light transmission and fluorescence method as well as its implications for visualizing and measuring in situ concentrations of QDs nanoparticles in the subsurface environment are discussed.

The Effects of UV Emission from Compact Fluorescent Light Exposure on Human Dermal Fibroblasts and KeratinocytesIn Vitro

2012 ◽  
Vol 88 (6) ◽  
pp. 1497-1506 ◽  
Author(s):  
Tatsiana Mironava ◽  
Michael Hadjiargyrou ◽  
Marcia Simon ◽  
Miriam H. Rafailovich
Keyword(s):  
Light Exposure ◽  
Dermal Fibroblasts ◽  
Fluorescent Light ◽  
Human Dermal Fibroblasts ◽  
Uv Emission

Stability of vincristine sulfate, doxorubicin hydrochloride and etoposide phosphate admixtures in polyisoprene elastomeric pump supporting transition of the EPOCH regimen to outpatient care

2018 ◽  
Vol 25 (4) ◽  
pp. 831-840 ◽  
Author(s):  
Darren Svirskis ◽  
Sairam Behera ◽  
Neera Naidoo ◽  
Joanne Beachman ◽  
Tarsha Raina ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Chemical Stability ◽  
Healthcare Costs ◽  
Light Exposure ◽  
Outpatient Setting ◽  
Fluorescent Light ◽  
Doxorubicin Hydrochloride ◽  
Vincristine Sulfate ◽  
Etoposide Phosphate ◽  
Bed Days

Background The EPOCH regimen, consisting of vincristine sulfate, doxorubicin hydrochloride, and etoposide phosphate, is typically administered by continuous infusion over four days to oncology inpatients. If the EPOCH regimen was available to be administered through portable elastomeric pumps, chemotherapy could be transitioned to an outpatient setting, reducing inpatient bed days and overall healthcare costs. However, a lack of stability data for the admixtures in the elastomeric infusion devices currently prevents the transition of the regime to an outpatient setting. The purpose of this study is to determine the physical and chemical stability of the admixture in polyisoprene elastomeric pumps under different storage conditions to support the transition of the EPOCH regime to an outpatient setting. Methods The physico-chemical stability of three admixtures at a range of clinically relevant concentrations compounded in polyisoprene elastomeric infusors was determined when refrigerated at 2–6℃ over a 14-day period followed by 35℃ up to 7 days in the dark, and under standardized fluorescent light to simulate scenarios in clinical practice. Results All tested admixtures were compatible and the drugs were stable in the elastomeric infusors for up to 14 days when stored at 2–6℃ followed by 7 days at 35℃ in the dark, with nominal losses of <5%. The major degradant of etoposide phosphate was its active form etoposide. There was no degradation (<1% loss) found when the admixture was exposed to a standardized fluorescent light dose of 80 klux-h (25℃) for 10 h. The temperature and light conditions the infusors were exposed to during the stability study were more severe than the conditions determine during clinical administration. Conclusion The extended stability of the three infusional admixtures compounded in elastomeric infusion pumps demonstrated herein permits advance preparation and storage of these drugs, reducing pharmacy compounding resources. The demonstrated stability at 35℃ and under light exposure, conditions more severe than those experienced during clinical practice, support continuous infusions for up to seven days from the elastomeric infusors without a loss of potency. The proven stability of the EPOCH regimens in the tested elastomeric infusion device supports the transition of treatment to an outpatient setting which will reduce inpatient bed days and overall healthcare costs.

The Association of Cutaneous Malignant Melanoma and Fluorescent Light Exposure

1992 ◽  
Vol 135 (7) ◽  
pp. 749-762 ◽  
Author(s):  
Stephen D. Walter ◽  
Loraine D. Marrett ◽  
Harry S. Shannon ◽  
Lynn From ◽  
Clyde Hertzman
Keyword(s):  
Malignant Melanoma ◽  
Light Exposure ◽  
Cutaneous Malignant Melanoma ◽  
Fluorescent Light

Tea catechin role in decreasing the oxidation of dairy beverages containing linseed oil

2020 ◽  
pp. 1-8
Author(s):  
Marcela Boroski ◽  
Hélène J. Giroux ◽  
Jesui V. Visentainer ◽  
Pascal Dubé ◽  
Yves Desjardins ◽  
...  
Keyword(s):  
High Temperature ◽  
Light Exposure ◽  
Linseed Oil ◽  
Storage Period ◽  
Conjugated Dienes ◽  
Fluorescent Light ◽  
Epicatechin Gallate ◽  
Heat Temperature ◽  
Tea Extract ◽  
Dairy Beverages

Abstract. Dairy beverages containing emulsified linseed oil is a suitable vehicle for delivering polyunsaturated fatty acids to consumers. However, these beverages are prone to oxidation. The purpose of this study was to evaluate the effect of adding various concentrations (0, 0.001, 0.01 and 0.1% (w/w)) of green tea extract (GTE) to dairy beverages (DB) containing linseed oil (2.0%, w/w), in order to inhibit lipid oxidation during storage at high temperature (50 °C) or under fluorescent light exposure. During storage, the concentration of catechin (C), epicatechin (EC) and epicatechin gallate (ECG) were significantly reduced ( P ≤ 0.05) and degradation rate was greater when the DB were exposed to light (C 35%, EC 74% and ECG 68%) as compared to high temperature (C 34%, EC 45% and ECG 49%). In DB without GTE, the conjugated dienes (CD) hydroperoxides concentration increased significantly ( P ≤ 0.05) from 23 mmol kg−1 fat to 243 mmol kg−1 fat under 6-day-light exposition, and to 83 mmol kg−1 fat under 6-day-heat temperature. The addition of GTE significantly increased the antioxidant capacity of DB and reduced the formation of CD, propanal and hexanal, induced by light exposure or high temperature. GTE at 0.10% completely inhibited CD formation during the storage period and reduced propanal and hexanal concentrations below the threshold.

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