Embryonic cardiotoxicity of weak aryl hydrocarbon receptor agonists and CYP1A inhibitor fluoranthene in the Atlantic killifish (Fundulus heteroclitus)

2016 ◽  
Vol 188 ◽  
pp. 45-51 ◽  
Author(s):  
D.R. Brown ◽  
B.W. Clark ◽  
L.V.T. Garner ◽  
R.T. Di Giulio
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Fundulus Heteroclitus ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon ◽  
Atlantic Killifish

scholarly journals Targeted mutagenesis of aryl hydrocarbon receptor 2a and 2b genes in Atlantic killifish (Fundulus heteroclitus)

2015 ◽  
Vol 158 ◽  
pp. 192-201 ◽  
Author(s):  
Neelakanteswar Aluru ◽  
Sibel I. Karchner ◽  
Diana G. Franks ◽  
Diane Nacci ◽  
Denise Champlin ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Fundulus Heteroclitus ◽  
Targeted Mutagenesis ◽  
Aryl Hydrocarbon ◽  
Atlantic Killifish

Aryl hydrocarbon receptor polymorphisms and dioxin resistance in Atlantic killifish (Fundulus heteroclitus)

2004 ◽  
Vol 14 (2) ◽  
pp. 131-143 ◽  
Author(s):  
Mark E Hahn ◽  
Sibel I Karchner ◽  
Diana G Franks ◽  
Rebeka R Merson
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Fundulus Heteroclitus ◽  
Aryl Hydrocarbon ◽  
Atlantic Killifish

EFFECT OF ARYL HYDROCARBON RECEPTOR AGONISTS AND LIPOPOLYSACCHARIDE ON BENZO(A)PYRENE GENOTOXICITY MARKERS

2019 ◽  
pp. 19-25 ◽  
Author(s):  
V. N. Babakov ◽  
N. Yu. Rogovskaya ◽  
I. D. Kurdyukov ◽  
P. P. Beltyukov ◽  
S. A. Dulov ◽  
...  
Keyword(s):  
Dna Repair ◽  
Aryl Hydrocarbon Receptor ◽  
P53 Protein ◽  
Control Level ◽  
Repair System ◽  
Human Hepatoma Cells ◽  
Kinase Activation ◽  
Receptor Agonists ◽  
Checkpoint Kinases ◽  
Aryl Hydrocarbon

The effect of aryl hydrocarbon receptor agonists (FICZ and ITE), as well as lipopolysaccharide under the toxic action of benzo(a)pyrene in HepaRG human hepatoma cells was evaluated. Active forms of the key stress-activated kinase cascades and DNA repair system proteins were used as markers of the genotoxic action of benzo(a)pyrene. A mixture of lipopolysaccharide with benzo(a)pyrene increases benzo(a)pyrene cytotoxicity and reduces the activation of DNA repair system proteins below the control level. Aryl hydrocarbon receptor agonists (FICZ and ITE) exhibit a cytoprotective effect against benzo(a) pyrene, enhance Akt1 kinase activation, and downregulate activation of the p53 protein and Chk1 and Chk2 checkpoint kinases. Thus, FICZ and ITE reduce the genotoxicity of benzo(a)pyrene.

scholarly journals Lineage‐dependent effects of aryl hydrocarbon receptor agonists contribute to liver tumorigenesis

Hepatology ◽  
2015 ◽  
Vol 61 (2) ◽  
pp. 548-560 ◽  
Author(s):  
Joshua A. Harrill ◽  
Bethany B Parks ◽  
Eliane Wauthier ◽  
J. Craig Rowlands ◽  
Lola M. Reid ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon

scholarly journals Characterization of aryl hydrocarbon receptor agonists in sediments of Wenyu River, Beijing, China

2009 ◽  
Vol 43 (9) ◽  
pp. 2441-2448 ◽  
Author(s):  
Jianping Luo ◽  
Mei Ma ◽  
Jinmiao Zha ◽  
Zijian Wang
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon ◽  
Beijing China

Characterization of Quinoline Yellow Dyes As Transient Aryl Hydrocarbon Receptor Agonists

2020 ◽  
Vol 33 (3) ◽  
pp. 742-750
Author(s):  
Patrick Tarnow ◽  
Catrin Zordick ◽  
Alex Bottke ◽  
Berit Fischer ◽  
Friederike Kühne ◽  
...  
Keyword(s):  
Aryl Hydrocarbon Receptor ◽  
Receptor Agonists ◽  
Aryl Hydrocarbon ◽  
Quinoline Yellow
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