In vitro hepatic microsomal metabolism of meloxicam in koalas (Phascolarctos cinereus), brushtail possums (Trichosurus vulpecula), ringtail possums (Pseudocheirus peregrinus), rats (Rattus norvegicus) and dogs (Canis lupus familiaris)

2014 ◽  
Vol 161 ◽  
pp. 7-14 ◽  
Author(s):  
B. Kimble ◽  
K.M. Li ◽  
P. Valtchev ◽  
D.P. Higgins ◽  
M.B. Krockenberger ◽  
...  
Keyword(s):  
Canis Lupus ◽  
Rattus Norvegicus ◽  
Trichosurus Vulpecula ◽  
Canis Lupus Familiaris ◽  
Microsomal Metabolism ◽  
Phascolarctos Cinereus ◽  
Pseudocheirus Peregrinus

scholarly journals In Vitro Hepatic Assessment of Cineole and Its Derivatives in Common Brushtail Possums (Trichosurus vulpecula) and Rodents

Biology ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1326
Author(s):  
Ravneel R. Chand ◽  
Mhairi Nimick ◽  
Belinda Cridge ◽  
Rhonda J. Rosengren
Keyword(s):  
Catalytic Activity ◽  
Management Strategies ◽  
Brushtail Possum ◽  
Trichosurus Vulpecula ◽  
Cytochrome P450 3A ◽  
Phascolarctos Cinereus ◽  
Catalytic Activities ◽  
Rats And Mice ◽  
Drug Metabolising Enzymes

Folivore marsupials, such as brushtail possum (Trichosurus Vulpecula) and koala (Phascolarctos cinereus), can metabolise higher levels of dietary terpenes, such as cineole, that are toxic to eutherian mammals. While the highly efficient drug metabolising enzymes, cytochrome P450 3A (CYP3A) and phase II conjugating enzymes (UDP-glucuronosyltransferase, UGT), are involved in the metabolism of high levels of dietary terpenes, evidence for inhibitory actions on these enzymes by these terpenes is scant. Thus, this study investigated the effect of cineole and its derivatives on catalytic activities of hepatic CYP3A and UGT in mice, rats, and possums. Results showed that cineole (up to 50 µM) and its derivatives (up to 25 µM) did not significantly inhibit CYP3A and UGT activities in mice, rats, and possums (both in silico and in vitro). Interestingly, basal hepatic CYP3A catalytic activity in the possums was ~20% lower than that in rats and mice. In contrast, possums had ~2-fold higher UGT catalytic activity when compared to mice and rats. Thus, these basal enzymatic differences may be further exploited in future pest management strategies.

Primary osteoblast culture from domestic dog (Canis lupus familiaris)

2016 ◽  
Author(s):  
Ines Pedro Perpetuo ◽  
Richard Meeson ◽  
Andrew Pitsillides ◽  
Michael Doube ◽  
Isabel Orriss
Keyword(s):  
Canis Lupus ◽  
Domestic Dog ◽  
Canis Lupus Familiaris ◽  
Primary Osteoblast ◽  
Osteoblast Culture

Canis lupus familiaris. En: SAyDS�SAREM (eds.) Categorizaci�n 2019 de los mam�feros de Argentina seg�n su riesgo de extinci�n.

2019 ◽  
Author(s):  
Bernardo Lartigau ◽  
Gustavo Aprile ◽  
Mart�n Monteverde ◽  
Mario Santos Beade ◽  
Juan Manuel Lartigau ◽  
...  
Keyword(s):  
Canis Lupus ◽  
Canis Lupus Familiaris

scholarly journals Do domestic dogs (Canis lupus familiaris) perceive the Delboeuf illusion?

2016 ◽  
Vol 20 (3) ◽  
pp. 427-434 ◽  
Author(s):  
Maria Elena Miletto Petrazzini ◽  
Angelo Bisazza ◽  
Christian Agrillo
Keyword(s):  
Canis Lupus ◽  
Domestic Dogs ◽  
Canis Lupus Familiaris ◽  
Delboeuf Illusion
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