scholarly journals Cytochrome P450 CYP2 genes in the common cormorant: Evolutionary relationships with 130 diapsid CYP2 clan sequences and chemical effects on their expression

2011 ◽  
Vol 153 (3) ◽  
pp. 280-289 ◽  
Author(s):  
Akira Kubota ◽  
John J. Stegeman ◽  
Jared V. Goldstone ◽  
David R. Nelson ◽  
Eun-Young Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Evolutionary Relationships ◽  
Chemical Effects ◽  
The Common ◽  
Common Cormorant

scholarly journals Myopathy with Concurrent Tadalafil and Simvastatin

2009 ◽  
Vol 2009 ◽  
pp. 1-3
Author(s):  
Maria Pia Gargante ◽  
Marco Vacante ◽  
Cristina Russo ◽  
Mariano Malaguarnera
Keyword(s):  
Cytochrome P450 ◽  
Muscle Damage ◽  
Muscle Pain ◽  
Penile Erection ◽  
The Common ◽  
Cytochrome P450 Isoenzyme

A 48-year-old man, using statin, was admitted to hospital with progressive myalgia after consumption of tadalafil and simvastatin. Muscle pain and penile erection disappeared seven days after interruption of therapy. This case demonstrates the interaction of tadalafil with simvastatin resulting in myopathy. Muscle damage could be attributed to the common metabolic way of these two drugs which is cytochrome P450 isoenzyme system.

Evolutionary relationships among proteins in the phytohemagglutinin-arcelin-?-amylase inhibitor family of the common bean and its relatives

1994 ◽  
Vol 26 (4) ◽  
pp. 1103-1113 ◽  
Author(s):  
T. Erik Mirkov ◽  
Janice M. Wahlstrom ◽  
Kiyoshi Hagiwara ◽  
Flavio Finardi-Filho ◽  
Susanne Kjemtrup ◽  
...  
Keyword(s):  
Common Bean ◽  
Evolutionary Relationships ◽  
Amylase Inhibitor ◽  
The Common

scholarly journals The cytochrome P450 (CYP) superfamily in cnidarians

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kirill V. Pankov ◽  
Andrew G. McArthur ◽  
David A. Gold ◽  
David R. Nelson ◽  
Jared V. Goldstone ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Phylogenetic Analyses ◽  
Xenobiotic Metabolism ◽  
Nematostella Vectensis ◽  
Individual Species ◽  
Evolutionary Relationships ◽  
Hydra Vulgaris ◽  
Acropora Digitifera ◽  
The Individual ◽  
Important Enzyme

AbstractThe cytochrome P450 (CYP) superfamily is a diverse and important enzyme family, playing a central role in chemical defense and in synthesis and metabolism of major biological signaling molecules. The CYPomes of four cnidarian genomes (Hydra vulgaris, Acropora digitifera, Aurelia aurita, Nematostella vectensis) were annotated; phylogenetic analyses determined the evolutionary relationships amongst the sequences and with existing metazoan CYPs. 155 functional CYPs were identified and 90 fragments. Genes were from 24 new CYP families and several new subfamilies; genes were in 9 of the 12 established metazoan CYP clans. All species had large expansions of clan 2 diversity, with H. vulgaris having reduced diversity for both clan 3 and mitochondrial clan. We identified potential candidates for xenobiotic metabolism and steroidogenesis. That each genome contained multiple, novel CYP families may reflect the large evolutionary distance within the cnidarians, unique physiology in the cnidarian classes, and/or different ecology of the individual species.

scholarly journals Universal nomenclature for oxytocin–vasotocin ligand and receptor families

Nature ◽  
2021 ◽  
Vol 592 (7856) ◽  
pp. 747-755
Author(s):  
Constantina Theofanopoulou ◽  
Gregory Gedman ◽  
James A. Cahill ◽  
Cedric Boeckx ◽  
Erich D. Jarvis
Keyword(s):  
Common Ancestor ◽  
Gene Families ◽  
Evolutionary Relationships ◽  
Segmental Duplications ◽  
Single Receptor ◽  
Genomic Analyses ◽  
Local Duplication ◽  
Specific Receptors ◽  
The Common ◽  
Genome Assemblies

AbstractOxytocin (OXT; hereafter OT) and arginine vasopressin or vasotocin (AVP or VT; hereafter VT) are neurotransmitter ligands that function through specific receptors to control diverse functions1,2. Here we performed genomic analyses on 35 species that span all major vertebrate lineages, including newly generated high-contiguity assemblies from the Vertebrate Genomes Project3,4. Our findings support the claim5 that OT (also known as OXT) and VT (also known as AVP) are adjacent paralogous genes that have resulted from a local duplication, which we infer was through DNA transposable elements near the origin of vertebrates and in which VT retained more of the parental sequence. We identified six major oxytocin–vasotocin receptors among vertebrates. We propose that all six of these receptors arose from a single receptor that was shared with the common ancestor of invertebrates, through a combination of whole-genome and large segmental duplications. We propose a universal nomenclature based on evolutionary relationships for the genes that encode these receptors, in which the genes are given the same orthologous names across vertebrates and paralogous names relative to each other. This nomenclature avoids confusion due to differential naming in the pre-genomic era and incomplete genome assemblies, furthers our understanding of the evolution of these genes, aids in the translation of findings across species and serves as a model for other gene families.

scholarly journals The Common Ancestor of Deinococcus Species was Rod-Shaped

2018 ◽  
Vol 11 (1) ◽  
pp. 252-258 ◽  
Author(s):  
Yusuke Morita ◽  
Hiromi Nishida
Keyword(s):  
Horizontal Transfer ◽  
Phylogenetic Trees ◽  
Common Ancestor ◽  
Thermus Thermophilus ◽  
Spherical Shape ◽  
Evolutionary Relationships ◽  
The Common ◽  
Formation System

Background:The genusDeinococcusconsists of species in rod-shape (Bacilli) and spherical shape (Cocci).Objective:In this study, we aimed to determine whether the common ancestor ofDeinococcusspecies was rod-shaped or spherical.Methods:We compared the homologs of the proteins related to the rod-shape in bacteria (MreB, MreC, MreD, MrdA, RodA, and RodZ) in variousDeinococcusspecies andThermus thermophilus.Results:The phylogenetic trees based on each protein and the homologs reflected the evolutionary relationships of the species, indicating that the Horizontal transfer of the genes did not occur during theDeinococcusevolution.Conclusion:The ancestor of the genusDeinococcuswas rod-shaped, and the spherical forms appeared when the rod-shaped formation system was lost during evolution and diversification within the genus.

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