Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae)

2010 ◽  
Vol 152 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Milena Mechkarska ◽  
Eman Ahmed ◽  
Laurent Coquet ◽  
Jérôme Leprince ◽  
Thierry Jouenne ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Therapeutic Potential ◽  
Skin Secretions ◽  
Clawed Frog ◽  
Xenopus Borealis

Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae)

2011 ◽  
Vol 153 (3) ◽  
pp. 350-354 ◽  
Author(s):  
J. Michael Conlon ◽  
Milena Mechkarska ◽  
Eman Ahmed ◽  
Jérôme Leprince ◽  
Hubert Vaudry ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Purification And Properties ◽  
Skin Secretions ◽  
Clawed Frog

Antimicrobial Peptides from Skin Secretions ofHypsiboas pulchellus(Anura: Hylidae)

2014 ◽  
Vol 77 (4) ◽  
pp. 831-841 ◽  
Author(s):  
Alvaro Siano ◽  
María Verónica Húmpola ◽  
Eliandre de Oliveira ◽  
Fernando Albericio ◽  
Arturo C. Simonetta ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Skin Secretions

A comparison of host-defense peptides in skin secretions of female Xenopus laevis×Xenopus borealis and X. borealis×X. laevis F1 hybrids

Peptides ◽  
2013 ◽  
Vol 45 ◽  
pp. 1-8 ◽  
Author(s):  
Milena Mechkarska ◽  
Manju Prajeep ◽  
Jérôme Leprince ◽  
Hubert Vaudry ◽  
Mohammed A. Meetani ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Host Defense ◽  
F1 Hybrids ◽  
Host Defense Peptides ◽  
Skin Secretions ◽  
Defense Peptides ◽  
Xenopus Borealis

A Review of Antimicrobial Peptides: Its Function, Mode of Action and Therapeutic Potential

2022 ◽  
Vol 28 (1) ◽  
Author(s):  
Sehrish Nayab ◽  
Muhammad Aamir Aslam ◽  
Sajjad ur Rahman ◽  
Zia ud Din Sindhu ◽  
Sanaullah Sajid ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Mode Of Action ◽  
Therapeutic Potential

Structure-function relationships in bombinins H, antimicrobial peptides from Bombina skin secretions☆

Peptides ◽  
2000 ◽  
Vol 21 (11) ◽  
pp. 1673-1679 ◽  
Author(s):  
M.Luisa Mangoni ◽  
Nicoletta Grovale ◽  
Alessandra Giorgi ◽  
Giuseppina Mignogna ◽  
Maurizio Simmaco ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Structure Function ◽  
Skin Secretions

scholarly journals Development of Antimicrobial Peptides from Amphibians

Antibiotics ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 772
Author(s):  
Maria Luisa Mangoni ◽  
Bruno Casciaro
Keyword(s):  
Xenopus Laevis ◽  
Antimicrobial Peptides ◽  
Anuran Species ◽  
Skin Secretions

Since the discovery of magainins from the skin secretions of the African toad Xenopus laevis by Michael Zasloff in 1987, an increasing number of antimicrobial peptides (AMPs) has been identified in different anuran species and studied in detail [...]

scholarly journals CancerGram: An Effective Classifier for Differentiating Anticancer from Antimicrobial Peptides

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1045
Author(s):  
Michał Burdukiewicz ◽  
Katarzyna Sidorczuk ◽  
Dominik Rafacz ◽  
Filip Pietluch ◽  
Mateusz Bąkała ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Cancer Cells ◽  
Plasma Membranes ◽  
Therapeutic Potential ◽  
Kappa Statistic ◽  
R Package ◽  
Bioactive Molecules ◽  
Membrane Composition ◽  
Anticancer Peptides ◽  
Multicellular Organisms

Antimicrobial peptides (AMPs) constitute a diverse group of bioactive molecules that provide multicellular organisms with protection against microorganisms, and microorganisms with weaponry for competition. Some AMPs can target cancer cells; thus, they are called anticancer peptides (ACPs). Due to their small size, positive charge, hydrophobicity and amphipathicity, AMPs and ACPs interact with negatively charged components of biological membranes. AMPs preferentially permeabilize microbial membranes, but ACPs additionally target mitochondrial and plasma membranes of cancer cells. The preference towards mitochondrial membranes is explained by their membrane potential, membrane composition resulting from α-proteobacterial origin and the fact that mitochondrial targeting signals could have evolved from AMPs. Taking into account the therapeutic potential of ACPs and millions of deaths due to cancer annually, it is of vital importance to find new cationic peptides that selectively destroy cancer cells. Therefore, to reduce the costs of experimental research, we have created a robust computational tool, CancerGram, that uses n-grams and random forests for predicting ACPs. Compared to other ACP classifiers, CancerGram is the first three-class model that effectively classifies peptides into: ACPs, AMPs and non-ACPs/non-AMPs, with AU1U amounting to 0.89 and a Kappa statistic of 0.65. CancerGram is available as a web server and R package on GitHub.

scholarly journals Development and Challenges of Antimicrobial Peptides for Therapeutic Applications

Antibiotics ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 24 ◽  
Author(s):  
Charles H. Chen ◽  
Timothy K. Lu
Keyword(s):  
Antimicrobial Peptides ◽  
Soil Bacteria ◽  
Bacterial Infections ◽  
Mechanisms Of Action ◽  
The Body ◽  
Antimicrobial Drugs ◽  
Skin Secretions ◽  
Approved Drugs ◽  
Topical Medications ◽  
Fda Approved Drugs

More than 3000 antimicrobial peptides (AMPs) have been discovered, seven of which have been approved by the U.S. Food and Drug Administration (FDA). Now commercialized, these seven peptides have mostly been utilized for topical medications, though some have been injected into the body to treat severe bacterial infections. To understand the translational potential for AMPs, we analyzed FDA-approved drugs in the FDA drug database. We examined their physicochemical properties, secondary structures, and mechanisms of action, and compared them with the peptides in the AMP database. All FDA-approved AMPs were discovered in Gram-positive soil bacteria, and 98% of known AMPs also come from natural sources (skin secretions of frogs and toxins from different species). However, AMPs can have undesirable properties as drugs, including instability and toxicity. Thus, the design and construction of effective AMPs require an understanding of the mechanisms of known peptides and their effects on the human body. This review provides an overview to guide the development of AMPs that can potentially be used as antimicrobial drugs.

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