Ecotoxicity of a brominated flame retardant (tetrabromobisphenol A) and its derivatives to aquatic organisms

2010 ◽  
Vol 152 (4) ◽  
pp. 407-412 ◽  
Author(s):  
T. Debenest ◽  
F. Gagné ◽  
A.-N. Petit ◽  
C. André ◽  
M. Kohli ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Aquatic Organisms ◽  
Tetrabromobisphenol A ◽  
Brominated Flame Retardant

Comparative toxicity of a brominated flame retardant (tetrabromobisphenol A) on microalgae with single and multi-species bioassays

Chemosphere ◽  
2011 ◽  
Vol 85 (1) ◽  
pp. 50-55 ◽  
Author(s):  
Timothée Debenest ◽  
Anne-Nöelle Petit ◽  
François Gagné ◽  
Mohan Kohli ◽  
Nien Nguyen ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Tetrabromobisphenol A ◽  
Brominated Flame Retardant ◽  
Comparative Toxicity

Effects of tetrabromobisphenol A, brominated flame retardant, in ICR mice after prenatal and postnatal exposure

2006 ◽  
Vol 44 (8) ◽  
pp. 1408-1413 ◽  
Author(s):  
Y. Tada ◽  
T. Fujitani ◽  
N. Yano ◽  
H. Takahashi ◽  
K. Yuzawa ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Tetrabromobisphenol A ◽  
Postnatal Exposure ◽  
Brominated Flame Retardant ◽  
Icr Mice

Enhanced debromination of tetrabromobisphoenol a by zero-valent copper-nanoparticle-modified green rusts

2019 ◽  
Vol 6 (3) ◽  
pp. 970-980 ◽  
Author(s):  
Liping Fang ◽  
Ru Liu ◽  
Ling Xu ◽  
Ji Li ◽  
Li-Zhi Huang ◽  
...  
Keyword(s):  
Flame Retardant ◽  
Tetrabromobisphenol A ◽  
Copper Nanoparticle ◽  
Brominated Flame Retardant ◽  
Green Rusts

Green rusts (GRs) interlayered with Cl−, SO42−, and CO32− were used to reduce tetrabromobisphenol A (TBBPA), which is the most widely used brominated flame retardant.

scholarly journals Absence of neurotoxicity and lack of neurobehavioral consequences due to exposure to tetrabromobisphenol A (TBBPA) exposure in humans, animals and zebrafish

2019 ◽  
Vol 94 (1) ◽  
pp. 59-66 ◽  
Author(s):  
Sam Kacew ◽  
A. Wallace Hayes
Keyword(s):  
Flame Retardant ◽  
Parent Compound ◽  
Consumer Products ◽  
The Body ◽  
Tetrabromobisphenol A ◽  
Human Breast Milk ◽  
Target Tissue ◽  
Brominated Flame Retardant ◽  
The Brain

AbstractTetrabromobisphenol A (2,2′,6,6′-tetrabromo-4,4′-isopropylidenediphenol, CAS no. 79-94-7) (TBBPA) is an effective brominated flame retardant present in many consumer products whose effectiveness is attributable to its ability to retard flames and consequently save human lives. Toxicokinetic studies revealed that TBBPA when absorbed via the gastrointestinal tract is rapidly metabolized to glucuronide or sulfate metabolites which are rapidly eliminated by the kidney. TBBPA does not accumulate in the body and there is no evidence that the parent compound is present in the brain. Although this brominated flame retardant was detected in human breast milk and serum, there was no evidence that TBBPA reached the brain in in vivo animal studies as reflected by the absence of neuropathological, neurotoxic, or behavioral alterations indicating that the central nervous system is not a target tissue. These animal investigations were further supported by use of the larval/embryo observations that TBBPA did not produce behavioral changes in a larval/embryo zebrafish a model of chemical-induced neurotoxicity. Although some protein expressions were increased, deceased or not affected in the blood–brain barrier indicating no evidence that TBBPA entered the brain, the changes were contradictory, or gender related, and behavior was not affected supporting that this compound was not neurotoxic. Taken together, TBBPA does not appear to target the brain and is not considered as a neurotoxicant.

scholarly journals The widely utilized brominated flame retardant tetrabromobisphenol A (TBBPA) is a potent inhibitor of the SERCA Ca2+ pump

2007 ◽  
Vol 408 (3) ◽  
pp. 407-415 ◽  
Author(s):  
Oluseye A. Ogunbayo ◽  
Francesco Michelangeli
Keyword(s):  
Flame Retardant ◽  
Specific Inhibitor ◽  
Tryptophan Fluorescence ◽  
Major Effect ◽  
Phospholipid Bilayer ◽  
Tetrabromobisphenol A ◽  
Brominated Flame Retardant ◽  
Low Concentrations ◽  
Manufactured Products ◽  
Endocrine Disrupting

TBBPA (tetrabromobisphenol A) is currently the most widely used type of BFR (brominated flame retardant) employed to reduce the combustibility of a large variety of electronic and other manufactured products. Recent studies have indicated that BFRs, including TBBPA, are bio-accumulating within animal and humans. BFRs including TBBPA have also been shown to be cytotoxic and potentially endocrine-disrupting to a variety of cells in culture. Furthermore, TBBPA has specifically been shown to cause disruption of Ca2+ homoeostasis within cells, which may be the underlying cause of its cytotoxicity. In this study, we have demonstrated that TBBPA is a potent non-isoform-specific inhibitor of the SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) (apparent Ki 0.46–2.3 μM), thus we propose that TBBPA inhibition of SERCA contributes in some degree to Ca2+ signalling disruption. TBBPA binds directly to the SERCA without the need to partition into the phospholipid bilayer. From activity results and Ca2+-induced conformational results, it appears that the major effect of TBBPA is to decrease the SERCA affinity for Ca2+ (increasing the Kd from approx. 1 μM to 30 μM in the presence of 10 μM TBBPA). Low concentrations of TBBPA can quench the tryptophan fluorescence of the SERCA and this quenching can be reversed by BHQ [2,5-di-(t-butyl)-1,4-hydroquinone] and 4-n-nonylphenol, but not thapsigargin, indicating that TBBPA and BHQ may be binding to similar regions in the SERCA.

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