Intracerebroventricular and intravenous administration of growth hormone secretagogue L-692,585, somatostatin, neuropeptide Y and galanin in pig: Dose-dependent effects on growth hormone secretion

2010 ◽  
Vol 151 (4) ◽  
pp. 412-419 ◽  
Author(s):  
S.-J. Cho ◽  
J.-S. Lee ◽  
E.D. Mathias ◽  
C. Chang ◽  
G.J. Hickey ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Neuropeptide Y ◽  
Intravenous Administration ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Growth Hormone Secretagogue ◽  
Dose Dependent

Evidence for a Leptin-Neuropeptide Y Axis for the Regulation of Growth Hormone Secretion in the Rat

1998 ◽  
Vol 67 (4) ◽  
pp. 291-300 ◽  
Author(s):  
Béatrice A.M. Vuagnat ◽  
Dominique D. Pierroz ◽  
Meriem Lalaoui ◽  
Piera Englaro ◽  
François P. Pralong ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Neuropeptide Y ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Regulation Of Growth

Neuropeptide Y directly inhibits growth hormone secretion by human pituitary somatotropic tumours

1987 ◽  
Vol 115 (1) ◽  
pp. 149-154 ◽  
Author(s):  
Eric F. Adams ◽  
Maria S. Venetikou ◽  
Christine A. Woods ◽  
S. Lacoumenta ◽  
J. M. Burrin
Keyword(s):  
Growth Hormone ◽  
Neuropeptide Y ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Inhibitory Effect ◽  
Pituitary Cells ◽  
Maximal Effect ◽  
Human Pituitary ◽  
Amino Acid Peptide ◽  
Gh Secretion

Abstract. Neuropeptide Y (NPY) is a 36 amino acid peptide, widely distributed throughout the brain and is found in hypothalamic neurones. This latter finding suggests that NPY may possess a hypophysiotropic function. A number of studies have demonstrated effects of NPY on LH and GH secretion by rat pituitary cells. We report here the results of experiments investigating the effects of NPY on GH secretion by tumorous human somatotropic pituitary cells in culture. NPY (0.25–25 nmol/l) inhibited GH secretion by 20–53%, the maximal effect depending upon the tumour studied. The potency of NPY was less than that of somatostatin (SRIH). The stimulatory effects of growth hormone releasing factor (GHRH) and theophylline were reduced by NPY, but NPY did not modify the inhibitory effect of SRIH on GH secretion. It is concluded that NPY may be involved in the control of GH secretion, at least by tumorous human pituitary somatotropes.

Growth hormone secretion in the guinea-pig

1990 ◽  
Vol 124 (3) ◽  
pp. 371-380 ◽  
Author(s):  
B. Gabrielsson ◽  
K. M. Fairhall ◽  
I. C. A. F. Robinson
Keyword(s):  
Growth Hormone ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Physiological Control ◽  
Gh Secretion ◽  
Dose Dependent Fashion ◽  
Growth Promoting ◽  
Dose Dependent

ABSTRACT The guinea-pig is unusual in that it continues to grow at a normal rate after hypophysectomy. Although its pituitary gland appears to contain a GH, this has not been isolated or characterized, and nothing is known about its secretion or physiological control. We have identified guinea-pig GH, established a sensitive heterologous radioimmunoassay and adapted our automatic blood microsampling method to study spontaneous GH secretion in this species. In male guinea-pigs, GH is released in an episodic pattern, reminiscent of the rat. Large multicomponent pulses of GH secretion occur every 3–4 h between periods of low or undetectable GH release, whereas most females showed a more uniform pulsatile pattern with pulses every 1–2 h. GH was released in response to GH-releasing factor (GRF) injections (2, 10 or 20 μg [Nle27]-GRF(1–29)NH2) in a dose-dependent fashion, and i.v. infusion of somatostatin (50 μg/h) blocked spontaneous GH pulses, eliciting a rebound release (from 2·0±0·8 (s.e.m.) to 36±17 μg/l 30 min after stopping the infusion). Infusions of a GH-releasing hexapeptide (100 or 400 μg/h for 4 h) also released GH. These results provide the first description of the pattern of GH release in the guinea-pig, and suggest that the striking episodic pattern is controlled by the same hypothalamic peptides that regulate GH in other species. Since the guinea-pig grows well in the absence of GH, this species may use GH for its metabolic, rather than growth-promoting actions. The guinea-pig may well prove a useful model, now that methods are available for studying its endogenous GH secretion. Journal of Endocrinology (1990) 124, 371–380

Interaction between Leptin and Neuropeptide Y on in vivo Growth Hormone Secretion

1998 ◽  
Vol 68 (3) ◽  
pp. 187-191 ◽  
Author(s):  
Eva Carro ◽  
Luisa M. Seoane ◽  
Rosa Señaris ◽  
Robert V. Considine ◽  
Felipe F. Casanueva ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Neuropeptide Y ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
In Vivo Growth

scholarly journals Molecular characterization of the bovine <i>GHRL</i> gene (Short Communication)

2009 ◽  
Vol 52 (1) ◽  
pp. 79-84 ◽  
Author(s):  
F. G. Colinet ◽  
D. Portetelle ◽  
R. Renaville
Keyword(s):  
Growth Hormone ◽  
Amino Acid ◽  
Short Communication ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Endogenous Ligand ◽  
Growth Hormone Secretagogue Receptor ◽  
Growth Hormone Secretagogue ◽  
Amino Acid Peptide

Abstract. Bovine ghrelin, a 27 amino acid peptide, has been identified in oxyntic glands of the abomasum. It is an endogenous ligand for growth hormone secretagogue receptor and stimulates food intake and growth hormone secretion. The bovine GHRL gene was completely sequenced and consists of five exons and four introns. Like mouse and human GHRL genes, we found that the bovine GHRL gene also contains a first non-coding exon of 21 bp. The bovine GHRL gene codes for 116 amino acid peptide named preproghrelin which contains the ghrelin peptide and another peptide similar to obestatin. Sequence analysis revealed eight polymorphisms, which are located in the non-coding sequence of the gene.

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