Risk assessment for endocrine disrupting chemical mixtures

2008 ◽  
Vol 148 (4) ◽  
pp. 455 ◽  
Author(s):  
H.R. Habibi ◽  
K.M. Jeffries ◽  
E.R. Nelson ◽  
L.J. Jackson
Keyword(s):  
Risk Assessment ◽  
Chemical Mixtures ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting

Correlates of Persistent Endocrine-Disrupting Chemical Mixtures among Reproductive-Aged Black Women

2021 ◽  
Author(s):  
Samantha Schildroth ◽  
Lauren A. Wise ◽  
Amelia K. Wesselink ◽  
Payton De La Cruz ◽  
Traci N. Bethea ◽  
...  
Keyword(s):  
Black Women ◽  
Chemical Mixtures ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting

Using Bayesian Shared Mean and Mixture Priors to Study Prenatal Endocrine Disrupting Chemical Mixtures and Neurodevelopment

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Ghassan Hamra ◽  
Kristen Lyall ◽  
Gayle Windham ◽  
Antonia Calafat ◽  
Andreas Sjodin ◽  
...  
Keyword(s):  
Chemical Mixtures ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting

scholarly journals Correlates of persistent endocrine disrupting chemical mixtures among reproductive-aged Black women

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
S. Schildroth ◽  
L.A. Wise ◽  
A. Wesselink ◽  
J. Weuve ◽  
V. Fruh ◽  
...  
Keyword(s):  
Black Women ◽  
Chemical Mixtures ◽  
Endocrine Disrupting Chemical ◽  
Endocrine Disrupting

scholarly journals A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Celinda M. Kofron ◽  
Tae Yun Kim ◽  
Fabiola Munarin ◽  
Arvin H. Soepriatna ◽  
Rajeev J. Kant ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Action Potentials ◽  
Induced Pluripotent Stem Cell ◽  
Human Action ◽  
Environmental Toxicants ◽  
Pharmaceutical Drugs ◽  
Industrial Chemicals ◽  
Endocrine Disrupting Chemical

AbstractCardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants can be severe, even life threatening, which necessitates a thorough evaluation of the human response to chemical compounds. Predicting risks for arrhythmia and sudden cardiac death accurately is critical for defining safety profiles. Currently available approaches have limitations including a focus on single select ion channels, the use of non-human species in vitro and in vivo, and limited direct physiological translation. We have advanced the robustness and reproducibility of in vitro platforms for assessing pro-arrhythmic cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues. Using automated algorithms and statistical analyses of eight comprehensive evaluation metrics of cardiac action potentials, we demonstrate that tissue-engineered human cardiac microtissues respond appropriately to physiological stimuli and effectively differentiate between high-risk and low-risk compounds exhibiting blockade of the hERG channel (E4031 and ranolazine, respectively). Further, we show that the environmental endocrine disrupting chemical bisphenol-A (BPA) causes acute and sensitive disruption of human action potentials in the nanomolar range. Thus, this novel human 3D in vitro pro-arrhythmic risk assessment platform addresses critical needs in cardiotoxicity testing for both environmental and pharmaceutical compounds and can be leveraged to establish safe human exposure levels.

scholarly journals Endocrine disrupting chemical-associated hair product use during pregnancy and gestational age at delivery: a pilot study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emma V. Preston ◽  
Victoria Fruh ◽  
Marlee R. Quinn ◽  
Michele R. Hacker ◽  
Blair J. Wylie ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Black Women ◽  
Pilot Study ◽  
Gestational Age ◽  
Endocrine Disrupting Chemical ◽  
Product Use ◽  
Frequent Use ◽  
Increased Risk ◽  
Endocrine Disrupting ◽  
Gestational Age At Delivery

Abstract Background Prenatal endocrine disrupting chemical (EDC) exposure has been associated with increased risk of preterm birth. Non-Hispanic Black women have higher incidence of preterm birth compared to other racial/ethnic groups and may be disproportionately exposed to EDCs through EDC-containing hair products. However, research on the use of EDC-associated hair products during pregnancy and risk of preterm birth is lacking. Therefore, the objective of this pilot study was to estimate associations of prenatal hair product use with gestational age at delivery in a Boston, Massachusetts area pregnancy cohort. Methods The study population consisted of a subset of participants enrolled in the Environmental Reproductive and Glucose Outcomes (ERGO) Study between 2018 and 2020. We collected self-reported data on demographics and hair product use using a previously validated questionnaire at four prenatal visits (median: 12, 19, 26, 36 weeks’ gestation) and abstracted gestational age at delivery from medical records. We compared gestational age and hair product use by race/ethnicity and used linear regression to estimate covariate-adjusted associations of product use and frequency of use at each study visit with gestational age at delivery. Primary models were adjusted for maternal age at enrollment and delivery method. Results Of the 154 study participants, 7% delivered preterm. Non-Hispanic Black participants had lower mean gestational age at delivery compared to non-Hispanic White participants (38.2 vs. 39.2 weeks) and were more likely to report ever and more frequent use of hair products. In regression models, participants reporting daily use of hair oils at visit 4 had lower mean gestational age at delivery compared to non-users (β: -8.3 days; 95% confidence interval: -14.9, -1.6). We did not find evidence of associations at earlier visits or with other products. Conclusions Frequent use of hair oils during late pregnancy may be associated with shorter gestational duration. As hair oils are more commonly used by non-Hispanic Black women and represent potentially modifiable EDC exposure sources, this may have important implications for the known racial disparity in preterm birth.

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