Donepezil is a strong antagonist of voltage-gated calcium and potassium channels in molluscan neurons

2007 ◽  
Vol 144 (4) ◽  
pp. 319-326 ◽  
Author(s):  
Elena I. Solntseva ◽  
Julia V. Bukanova ◽  
Evgeny Marchenko ◽  
Vladimir G. Skrebitsky
Keyword(s):  
Potassium Channels ◽  
Molluscan Neurons ◽  
Voltage Gated

scholarly journals Presynaptic Paraneoplastic Disorders of the Neuromuscular Junction: An Update

2021 ◽  
Vol 11 (8) ◽  
pp. 1035
Author(s):  
Maria Pia Giannoccaro ◽  
Patrizia Avoni ◽  
Rocco Liguori
Keyword(s):  
Potassium Channels ◽  
Neuromuscular Junction ◽  
Calcium Channels ◽  
Myasthenia Gravis ◽  
Neuromuscular Transmission ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Immune Mediated ◽  
Recent Developments ◽  
Myasthenic Syndrome

The neuromuscular junction (NMJ) is the target of a variety of immune-mediated disorders, usually classified as presynaptic and postsynaptic, according to the site of the antigenic target and consequently of the neuromuscular transmission alteration. Although less common than the classical autoimmune postsynaptic myasthenia gravis, presynaptic disorders are important to recognize due to the frequent association with cancer. Lambert Eaton myasthenic syndrome is due to a presynaptic failure to release acetylcholine, caused by antibodies to the presynaptic voltage-gated calcium channels. Acquired neuromyotonia is a condition characterized by nerve hyperexcitability often due to the presence of antibodies against proteins associated with voltage-gated potassium channels. This review will focus on the recent developments in the autoimmune presynaptic disorders of the NMJ.

scholarly journals Probing the Cavity of the Slow Inactivated Conformation of Shaker Potassium Channels

2007 ◽  
Vol 129 (5) ◽  
pp. 403-418 ◽  
Author(s):  
Gyorgy Panyi ◽  
Carol Deutsch
Keyword(s):  
Potassium Channels ◽  
Binding Site ◽  
Conformational Change ◽  
Marked Decrease ◽  
Selectivity Filter ◽  
Slow Inactivation ◽  
Voltage Gated ◽  
Activation Gate ◽  
Shaker Potassium Channels

Slow inactivation involves a local rearrangement of the outer mouth of voltage-gated potassium channels, but nothing is known regarding rearrangements in the cavity between the activation gate and the selectivity filter. We now report that the cavity undergoes a conformational change in the slow-inactivated state. This change is manifest as altered accessibility of residues facing the aqueous cavity and as a marked decrease in the affinity of tetraethylammonium for its internal binding site. These findings have implications for global alterations of the channel during slow inactivation and putative coupling between activation and slow-inactivation gates.

Effects of antiarrhythmic drugs on cloned cardiac voltage-gated potassium channels expressed in Xenopus oocytes

2000 ◽  
Vol 362 (1) ◽  
pp. 22-31 ◽  
Author(s):  
Sascha Rolf ◽  
Wilhelm Haverkamp ◽  
Martin Borggrefe ◽  
Ulrich Mußhoff ◽  
Lars Eckardt ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Xenopus Oocytes ◽  
Antiarrhythmic Drugs ◽  
Voltage Gated

Voltage-Gated Potassium Channels: Regulation by Accessory Subunits

2006 ◽  
Vol 12 (3) ◽  
pp. 199-210 ◽  
Author(s):  
Yan Li ◽  
Sung Yon Um ◽  
Thomas V. Mcdonald
Keyword(s):  
Potassium Channels ◽  
Voltage Gated ◽  
Accessory Subunits

scholarly journals Contribution of voltage-gated potassium channels to the regulation of apoptosis

FEBS Letters ◽  
2010 ◽  
Vol 584 (10) ◽  
pp. 2049-2056 ◽  
Author(s):  
Ildikò Szabò ◽  
Mario Zoratti ◽  
Erich Gulbins
Keyword(s):  
Potassium Channels ◽  
Voltage Gated
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