Differential action of proteases from Trimeresurus malabaricus, Naja naja and Daboia russellii venoms on hemostasis

2006 ◽  
Vol 143 (3) ◽  
pp. 295-302 ◽  
Author(s):  
C.D. Raghavendra Gowda ◽  
A. Nataraju ◽  
R. Rajesh ◽  
B.L. Dhananjaya ◽  
B.K. Sharath ◽  
...  
Keyword(s):  
Naja Naja ◽  
Trimeresurus Malabaricus ◽  
Differential Action

Differential Action of Phytochemicals on Platelet Apoptosis: A Biological Overview

2013 ◽  
Vol 20 (8) ◽  
pp. 1018-1027 ◽  
Author(s):  
R.M. Thushara ◽  
M. Hemshekhar ◽  
M.S. Santhosh ◽  
S. Devaraja ◽  
K. Kemparaju ◽  
...  
Keyword(s):  
Platelet Apoptosis ◽  
Differential Action

scholarly journals Cardiotoxin II from Taiwan cobra venom, Naja naja atra. Structure in solution and comparison among homologous cardiotoxins.

1994 ◽  
Vol 269 (38) ◽  
pp. 23500-23508
Author(s):  
R. Bhaskaran ◽  
C.C. Huang ◽  
Y.C. Tsai ◽  
G. Jayaraman ◽  
D.K. Chang ◽  
...  
Keyword(s):  
Cobra Venom ◽  
Naja Naja ◽  
Structure In Solution ◽  
Naja Atra ◽  
Cardiotoxin Ii

scholarly journals Neurotoxin from Venom of the Cobra, Naja naja siamensis

1972 ◽  
Vol 247 (10) ◽  
pp. 3008-3013
Author(s):  
David Cooper ◽  
E. Reich
Keyword(s):  
Naja Naja

scholarly journals Evaluation of the merit of the methanolic extract of Andrographis paniculata to supplement anti-snake venom in reversing secondary hemostatic abnormalities induced by Naja naja venom

3 Biotech ◽  
2021 ◽  
Vol 11 (5) ◽  
Author(s):  
Akshatha Ganesh Nayak ◽  
Nitesh Kumar ◽  
Smita Shenoy ◽  
Maya Roche
Keyword(s):  
Snake Venom ◽  
Methanolic Extract ◽  
Andrographis Paniculata ◽  
Thrombin Time ◽  
Drastic Reduction ◽  
Limited Effect ◽  
Naja Naja ◽  
Prolonged Aptt ◽  
Group 2 ◽  
Group 1

AbstractIncreasing evidence suggests a sizable involvement of hemotoxins in the morbidity associated with envenomation by the Indian spectacled cobra, Naja naja (N.N). This study investigates the ability of Indian polyvalent anti-snake venom (ASV), methanolic extract of Andrographis paniculata (MAP) and their combination in reversing the hemostatic abnormalities, viz. activated partial thromboplastin time(aPTT), prothrombin time(PT) and thrombin time(TT) in citrated plasma. These parameters were assessed in 2 groups of experiments. Group 1: Without the prior incubation of plasma with venom and Group 2: With prior incubation of plasma with venom for 90 min at 37°C. Venom caused significant (p < 0.001) prolongation in aPTT (175%), PT (49%) and TT (34%) in Group 1 and ASV could completely bring them back to normal. MAP showed a concentration-dependent reversal in aPTT, normalization of PT and prolongation of TT. When low concentration of ASV was supplemented with MAP, their combined effect in normalizing aPTT and PT improved by 37% and 26% respectively when compared to ASV alone. In Group 2, venom caused significant (p < 0.001) prolongation in aPTT (231%), PT (312%) and TT (245%). ASV had limited effect in reversing aPTT (52%), TT (31%) but completely normalized PT. MAP was marginally effective in reversing the prolonged aPTT and PT but caused further prolongation of TT. Combination of ASV and MAP was more effective than ASV alone in reversing venom-induced increase in aPTT (52%) and PT (29%). The study proved that, a drastic reduction of ASV by 70%, could be effectively supplemented by MAP in combating hemostatic abnormalities induced by NN venom.

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