Combinatorial chemistry and molecular diversityTools for molecular diversification and their applications in chemical biology

2006 ◽  
Vol 10 (3) ◽  
pp. 185-187 ◽  
Author(s):  
S SILVERMAN ◽  
P HERGENROTHER
Keyword(s):  
Combinatorial Chemistry ◽  
Chemical Biology

Sustainable Flow Synthesis of Encoded Beads for Combinatorial Chemistry and Chemical Biology

2018 ◽  
Vol 20 (8) ◽  
pp. 492-498 ◽  
Author(s):  
Hongxia Hu ◽  
Sergei Nikitin ◽  
Adam Bjørnholdt Berthelsen ◽  
Frederik Diness ◽  
Sanne Schoffelen ◽  
...  
Keyword(s):  
Combinatorial Chemistry ◽  
Chemical Biology ◽  
Flow Synthesis

Azides – Diazonium Ions – Triazenes: Versatile Nitrogen-rich Functional Groups

2014 ◽  
Vol 67 (3) ◽  
pp. 328 ◽  
Author(s):  
Dominik K. Kölmel ◽  
Nicole Jung ◽  
Stefan Bräse
Keyword(s):  
Functional Groups ◽  
Combinatorial Chemistry ◽  
Chemical Biology ◽  
Mitsunobu Reaction ◽  
Staudinger Ligation ◽  
Sandmeyer Reaction ◽  
Huisgen Reaction ◽  
Diazonium Ions ◽  
Synthetic Routes ◽  
Pschorr Reaction

For more than 100 years, nitrogen-rich compounds such as azides, diazonium ions, and triazenes have proved to be extremely valuable. Because these functional groups can be easily introduced into various substrates, they are frequently used nowadays. More importantly, they can be converted into a great number of other functional groups. The scope of this article is thus to summarize possible synthetic routes for the formation of these functional groups as well as to highlight some of the most prominent applications of these exciting moieties in chemical biology and combinatorial chemistry. Many of the most famous name reactions such as the Staudinger reduction, Staudinger ligation, Sandmeyer reaction, Wallach reaction, Mitsunobu reaction, Huisgen reaction, Balz–Schiemann reaction, Meerwein arylation, Pschorr reaction or Gomberg–Bachmann reaction are covered.

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