Genome-wide identification and transcriptional modulation of histone variants and modification related genes in the low pH-exposed marine rotifer Brachionus koreanus

2020 ◽  
Vol 36 ◽  
pp. 100748
Author(s):  
Young Hwan Lee ◽  
Min-Sub Kim ◽  
Haksoo Jeong ◽  
Atsushi Hagiwara ◽  
Jae-Seong Lee
Keyword(s):  
Histone Variants ◽  
Low Ph ◽  
Genome Wide ◽  
Brachionus Koreanus ◽  
Transcriptional Modulation ◽  
Marine Rotifer

Targeted cytochrome P450 3045C1 (CYP3045C1) gene mutation via CRISPR-Cas9 ribonucleoproteins in the marine rotifer Brachionus koreanus

Hydrobiologia ◽  
2018 ◽  
Vol 844 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Duck-Hyun Kim ◽  
Jihyeon Yu ◽  
Jun Chul Park ◽  
Chang-Bum Jeong ◽  
Sangsu Bae ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Gene Mutation ◽  
Brachionus Koreanus ◽  
Marine Rotifer

scholarly journals Nascent chromatin occupancy profiling reveals locus and factor specific chromatin maturation dynamics behind the DNA replication fork

2018 ◽  
Author(s):  
Mónica P. Gutiérrez ◽  
Heather K. MacAlpine ◽  
David M. MacAlpine
Keyword(s):  
Dna Replication ◽  
Replication Fork ◽  
Histone Variants ◽  
Replication Forks ◽  
Nucleosome Assembly ◽  
Genome Wide ◽  
Dna Binding Factors ◽  
Nucleotide Resolution ◽  
Kinetics Of ◽  
Regulatory Landscape

AbstractProper regulation and maintenance of the epigenome is necessary to preserve genome function. However, in every cell division, the epigenetic state is disassembled and then re-assembled in the wake of the DNA replication fork. Chromatin restoration on nascent DNA is a complex and regulated process that includes nucleosome assembly and remodeling, deposition of histone variants, and the re-establishment of transcription factor binding. To study the genome-wide dynamics of chromatin restoration behind the DNA replication fork, we developed Nascent Chromatin Occupancy Profiles (NCOPs) to comprehensively profile nascent and mature chromatin at nucleotide resolution. While nascent chromatin is inherently less organized than mature chromatin, we identified locus specific differences in the kinetics of chromatin maturation that were predicted by the epigenetic landscape, including the histone variant H2A.Z which marked loci with rapid maturation kinetics. The chromatin maturation at origins of DNA replication was dependent on whether the origin underwent initiation or was passively replicated from distal-originating replication forks suggesting distinct chromatin assembly mechanisms between activated and disassembled pre-replicative complexes. Finally, we identified sites that were only occupied transiently by DNA-binding factors following passage of the replication fork which may provide a mechanism for perturbations of the DNA replication program to shape the regulatory landscape of the genome.

Tributyltin Affects Retinoid X Receptor-Mediated Lipid Metabolism in the Marine Rotifer Brachionus koreanus

2019 ◽  
Vol 53 (13) ◽  
pp. 7830-7839 ◽  
Author(s):  
Min-Chul Lee ◽  
Elza Fonseca ◽  
Jun Chul Park ◽  
Deok-Seo Yoon ◽  
Hyuntae Choi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Retinoid X Receptor ◽  
Brachionus Koreanus ◽  
Marine Rotifer

Lipid metabolism modulation by five different food types in the monogonont marine rotifer Brachionus koreanus

Aquaculture ◽  
2019 ◽  
Vol 503 ◽  
pp. 596-601 ◽  
Author(s):  
Min-Chul Lee ◽  
Jun Chul Park ◽  
Deok-Seo Yoon ◽  
Hyuntae Choi ◽  
Kyung-Hoon Shin ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Brachionus Koreanus ◽  
Marine Rotifer

Effects of low temperature on longevity and lipid metabolism in the marine rotifer Brachionus koreanus

2020 ◽  
Vol 250 ◽  
pp. 110803
Author(s):  
Min-Chul Lee ◽  
Deok-Seo Yoon ◽  
Yoseop Lee ◽  
Hyuntae Choi ◽  
Kyung-Hoon Shin ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Low Temperature ◽  
Brachionus Koreanus ◽  
Marine Rotifer
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