d-Glucosamine, a natural aminosugar as organocatalyst for an ecofriendly direct aldol reaction of ketones with aromatic aldehydes in water

2008 ◽  
Vol 9 (5) ◽  
pp. 743-746 ◽  
Author(s):  
Nimisha Singh ◽  
Jyoti Pandey ◽  
R.P. Tripathi
Keyword(s):  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Direct Aldol Reaction

ChemInform Abstract: Highly Enantioselective Proline-Catalyzed Direct Aldol Reaction of Chloroacetone and Aromatic Aldehydes.

ChemInform ◽  
2012 ◽  
Vol 43 (37) ◽  
pp. no-no
Author(s):  
Angel Martinez-Castaneda ◽  
Belen Poladura ◽  
Humberto Rodriguez-Solla ◽  
Carmen Concellon ◽  
Vicente del Amo
Keyword(s):  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Direct Aldol Reaction

Highly Enantioselective Proline-Catalysed Direct Aldol Reaction of Chloroacetone and Aromatic Aldehydes

2012 ◽  
Vol 18 (17) ◽  
pp. 5188-5190 ◽  
Author(s):  
Ángel Martínez-Castañeda ◽  
Belén Poladura ◽  
Humberto Rodríguez-Solla ◽  
Carmen Concellón ◽  
Vicente del Amo
Keyword(s):  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Direct Aldol Reaction

The smallest organocatalyst in highly enantioselective direct aldol reaction in wet solvent-free conditions

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24311-24315 ◽  
Author(s):  
Sudipto Bhowmick ◽  
Sunita S. Kunte ◽  
Kartick C. Bhowmick
Keyword(s):  
Amino Acid ◽  
Room Temperature ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Natural Amino Acid ◽  
Asymmetric Aldol ◽  
Direct Aldol Reaction ◽  
Solvent Free Conditions ◽  
Asymmetric Aldol Reaction

The catalytic efficacy of the smallest organocatalyst, l-proline hydrazide, prepared from a cheaply available natural amino acid, such as l-proline, was studied for the direct asymmetric aldol reaction of various ketones with aromatic aldehydes at room temperature in the presence of several acid additives.

scholarly journals RuCl3 · nH2O as Catalyst for Diastereoselective Direct Aldol Reaction: An Efficient Route to Hormone Steroid Derivatives

2011 ◽  
Vol 2011 ◽  
pp. 1-5
Author(s):  
Khalil Tabatabaeian ◽  
Elahe Keshavarz ◽  
Manouchehr Mamaghani ◽  
Nosrat O. Mahmoodi
Keyword(s):  
Aldol Reaction ◽  
Reaction Times ◽  
Catalytic Efficiency ◽  
Aromatic Aldehydes ◽  
Direct Aldol Reaction ◽  
Efficient Route

-catalyzed regio- and diastereoselective direct aldol reaction of progesterone with aromatic aldehydes has been developed in good yields (58–78%). Advantages of this method include catalytic efficiency, short reaction times, and ease of operation and workup.

DFT investigation on Lewis base-catalyzed Lewis acid-mediated reactions: hypervalent silicon species as chiral organocatalysts in (direct) aldol reactions

2020 ◽  
Vol 44 (44) ◽  
pp. 19288-19293
Author(s):  
Sergio Rossi ◽  
Maurizio Benaglia ◽  
Laura Maria Raimondi
Keyword(s):  
Lewis Acid ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Lewis Base ◽  
Aldol Reactions ◽  
Enol Ethers ◽  
Silyl Enol Ethers ◽  
Direct Aldol Reaction

The stereoselective organocatalytic addition of silyl enol ethers to aromatic aldehydes catalyzed by bisphosphoramides and the direct aldol reaction between ketones and aromatic aldehydes promoted by phosphinoxides in the presence of tetrachlorosilane were investigated by the DFT approach.

Asymmetric Direct Aldol Reaction Catalyzed by (1R, 2R)-(+)-1, 2- Diammonium Cyclohexane-L-tartrate in Water

2019 ◽  
Vol 6 (2) ◽  
pp. 165-170
Author(s):  
Anirban Mondal ◽  
Kartick Chandra Bhowmick
Keyword(s):  
Large Volume ◽  
Room Temperature ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
High Yield ◽  
Direct Aldol Reaction ◽  
Reaction In Water

Background: A cheap and commercially available organocatalyst, (1R, 2R)-(+)-1, 2- diammonium cyclohexane-L-tartrate 1 was applied in direct aldol reaction in water. The organocatalyst 1 afforded aldol products from cyclohexanone and substituted aromatic aldehydes with high yield (up to 90%) and good stereoselectivity (up to 99% ee and up to 11.5:1 dr) in large volume of water (10 ml). Methods: The same aldol reaction when carried out in the presence of more expensive organocatalyst e.g. (1R, 2R)-(+)-1,2-diaminocyclohexane and 1,6-hexanediaoic acid as acid additive furnished the aldol products with only 20% yield, 2:1 anti/syn ratio and 92% ee. Results and Conclusion: In summary, we have applied a reasonably cheap and commercially available organocatalyst 1 for highly enantioselective direct aldol reaction in water at room temperature.

Design of Novel Hydrogen-Bonding Donor Organocatalysts and Their Application to Asymmetric Direct Aldol Reaction

Synlett ◽  
2017 ◽  
Vol 28 (11) ◽  
pp. 1363-1367 ◽  
Author(s):  
Tsuyoshi Miura ◽  
Hiroshi Akutsu ◽  
Kosuke Nakashima ◽  
Hikaru Yanai ◽  
Akira Kotani ◽  
...  
Keyword(s):  
Hydrogen Bonding ◽  
Catalytic Activity ◽  
Aldol Reaction ◽  
Aromatic Aldehydes ◽  
Aldol Reactions ◽  
Catalytic Activities ◽  
Asymmetric Catalytic ◽  
Direct Aldol Reaction ◽  
Double Hydrogen

Asymmetric catalytic activities of various organocatalysts bearing double hydrogen-bonding donor units showing different pK a values were examined for direct aldol reactions of cyclohexanone with aromatic aldehydes. Organocatalyst with motif exhibiting the highest acidity resulted in the corresponding aldol products with the highest enantioselectivity. A good correlation has been observed between the asymmetric catalytic activity for direct aldol reactions and acidities of double hydrogen-bonding donating units.

scholarly journals Simple and fast microwave-assisted ruthenium_catalyzed direct aldol reaction

2012 ◽  
Vol 1 (2) ◽  
pp. 91-94 ◽  
Author(s):  
Elahe Keshavarz ◽  
Khalil Tabatabaeian ◽  
Manouchehr Mamaghani ◽  
Nosrat O. Mahmoodi
Keyword(s):  
Aldol Reaction ◽  
Microwave Assisted ◽  
Direct Aldol Reaction
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