Re/HZSM-5: a new catalyst for ethane aromatization with improved stability

2003 ◽  
Vol 4 (12) ◽  
pp. 627-630 ◽  
Author(s):  
Anne Krogh ◽  
Anke Hagen ◽  
Thomas W Hansen ◽  
Claus Hviid Christensen ◽  
Iver Schmidt
Keyword(s):  
Ethane Aromatization ◽  
Improved Stability

Ethane aromatization and evolution of carbon deposits over nanosized and microsized Zn/ZSM-5 catalysts

2020 ◽  
Vol 10 (3) ◽  
pp. 835-843 ◽  
Author(s):  
Yan Zhang ◽  
Shide Wu ◽  
Xia Xu ◽  
Heqing Jiang
Keyword(s):  
Product Yield ◽  
Carbon Deposits ◽  
Ethane Aromatization ◽  
Improved Stability

Nanosized Zn/HZSM-5 facilitated the faster escape of light aromatics from zeolite channels and exhibited higher product yield and improved stability.

Improved Stability of a Thin-Film Multijunction Thermal Converter

2012 ◽  
Vol 132 (11) ◽  
pp. 1011-1017 ◽  
Author(s):  
Yasutaka Amagai ◽  
Hiroyuki Fujiki ◽  
Koji Shimizume ◽  
Shigeru Hidaka
Keyword(s):  
Thin Film ◽  
Thermal Converter ◽  
Improved Stability

Improved Stability of a Protein Vaccine Through Elimination of a Partially Unfolded State

2004 ◽  
Author(s):  
Colleen A. McHugh ◽  
Ralph F. Tammariello ◽  
Charles B. Millard ◽  
John H. Carra
Keyword(s):  
Protein Vaccine ◽  
Unfolded State ◽  
Improved Stability ◽  
Partially Unfolded

scholarly journals Unraveling the compositional heterogeneity and carrier dynamics of alkali cation doped 3D/2D perovskites with improved stability

2021 ◽  
Author(s):  
Ming-Chun Tang ◽  
Siyuan Zhang ◽  
Timothy J. Magnanelli ◽  
Nhan V. Nguyen ◽  
Edwin J. Heilweil ◽  
...  
Keyword(s):  
Relative Humidity ◽  
Comprehensive Analysis ◽  
Carrier Dynamics ◽  
Alkali Cation ◽  
Compositional Heterogeneity ◽  
Improved Stability

A comprehensive analysis of the compositional heterogeneity and carrier dynamics in novel rubidium-doped 3D/2D perovskites is investigated, showing a PCE over 20% and improved stability at ≈50% relative humidity without encapsulation.

scholarly journals The inhibitory potency of isoxazole-curcumin analogue for the management of breast cancer: A comparative in vitro and molecular modeling investigation

2021 ◽  
Author(s):  
Fiona C. Rodrigues ◽  
N. V. Anil Kumar ◽  
Gangadhar Hari ◽  
K. S. R. Pai ◽  
Goutam Thakur
Keyword(s):  
Breast Cancer ◽  
Herbal Remedy ◽  
Cancer Cell Line ◽  
Heterocyclic Ring ◽  
Regulatory Role ◽  
Multiple Traits ◽  
One Pot ◽  
Anticancer Efficacy ◽  
Improved Stability

AbstractCurcumin, a potent phytochemical derived from the spice element turmeric, has been identified as a herbal remedy decades ago and has displayed promise in the field of medicinal chemistry. However, multiple traits associated with curcumin, such as poor bioavailability and instability, limit its effectiveness to be accepted as a lead drug-like entity. Different reactive sites in its chemical structure have been identified to incorporate modifications as attempts to improving its efficacy. The diketo group present in the center of the structural scaffold has been touted as the group responsible for the instability of curcumin, and substituting it with a heterocyclic ring contributes to improved stability. In this study, four heterocyclic curcumin analogues, representing some broad groups of heterocyclic curcuminoids (isoxazole-, pyrazole-, N-phenyl pyrazole- and N-amido-pyrazole-based), have been synthesized by a simple one-pot synthesis and have been characterized by FTIR, 1H-NMR, 13C-NMR, DSC and LC–MS. To predict its potential anticancer efficacy, the compounds have been analyzed by computational studies via molecular docking for their regulatory role against three key proteins, namely GSK-3β—of which abnormal regulation and expression is associated with cancer; Bcl-2—an apoptosis regulator; and PR which is a key nuclear receptor involved in breast cancer development. One of the compounds, isoxazole-curcumin, has consistently indicated a better docking score than the other tested compounds as well as curcumin. Apart from docking, the compounds have also been profiled for their ADME properties as well as free energy binding calculations. Further, the in vitro cytotoxic evaluation of the analogues was carried out by SRB assay in breast cancer cell line (MCF7), out of which isoxazole-curcumin (IC50–3.97 µM) has displayed a sevenfold superior activity than curcumin (IC50–21.89 µM). In the collation of results, it can be suggested that isoxazole-curcumin behaves as a potential lead owing to its ability to be involved in a regulatory role with multiple significant cancer proteins and hence deserves further investigations in the development of small molecule-based anti-breast cancer agents. Graphic abstract

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