Early healing following TAXUS stent implantation: endothelial cell coverage is similar in overlapped TAXUS Express stents and bare metal stents in swine coronary arteries

2006 ◽  
Vol 7 (2) ◽  
pp. 90-92 ◽  
Author(s):  
S. Bailey ◽  
P. Seifert ◽  
B. Huibregtse ◽  
B. Poff
Keyword(s):  
Endothelial Cell ◽  
Coronary Arteries ◽  
Stent Implantation ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Cell Coverage ◽  
Early Healing

scholarly journals Extended Follow-Up by Serial Angioscopic Observation for Bare-Metal Stents in Native Coronary Arteries

2009 ◽  
Vol 2 (3) ◽  
pp. 205-212 ◽  
Author(s):  
Shinya Yokoyama ◽  
Masamichi Takano ◽  
Masanori Yamamoto ◽  
Shigenobu Inami ◽  
Shunta Sakai ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal

Abstract 16008: Improved Safety and Efficacy of a Novel Dual cRGD- and Everolimus-Coated Coronary Stent Compared to Everolimus-Eluting Stents in the Porcine Coronary Model

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Felix Vogt ◽  
Sebastian Mause ◽  
Jörg Schröder ◽  
Elisa Liehn ◽  
Nicole Krott ◽  
...  
Keyword(s):  
Stent Implantation ◽  
Soft Segment ◽  
Polymer Surface ◽  
Bare Metal Stents ◽  
Control Release ◽  
Drug Eluting Stent ◽  
Metal Stents ◽  
Bare Metal ◽  
Cross Sectional ◽  
Stent Strut

Background: Re-endothelialization after drug-eluting stent implantation is delayed. Integrin-binding cyclic Arg-Gly-As p (cRGD) peptide-loaded stents offer potential for enhanced early and late endothelial recovery by endothelial progenitor cell (EPC) anchorage. Here, a novel dual cRGD and everolimus-eluting stent was compared to an everolimus-eluting stent. Methods: The porcine coronary overstretch model was employed for analysis of Multi-Link Tetra bare metal stents with or without a specific conformal, mechanically robust polymer coating based on an aromatic polyetherurethaneurea with a soft segment of polytetramethyleneoxide and a hard segment of diphenylmethane diisocyanate and mixed diamines covered by a control-release layer. Stents were coated with immobilized cRGD, everolimus or cRGD+everolimus on the biostable PEA-40 polymer surface coating. Isolated porcine EPCs were labeled with cell tracker and infused into coronary arteries immediately after stent implantation. cRGD or everolimus recovered mass was quantified, re-endothelialization was assessed by scanning electron microscopy and area stenosis was quantified. Results: cRGD and everolimus recovered mass from PEA-40 cRGD/everolimus stents possessed a slow release profile. Marked EPC recruitment to stents was evidenced after intracoronary infusion of fluorescence-labeled EPCs. In cRGD+everolimus loaded stents, in-stent cross sectional stenosis was reduced and re-endothelialization above stent struts was accelerated (p<0.05 for both) while re-endothelialization between struts was similar (p>0.05) as compared to both everolimus-loaded and bare-metal stents. Conclusions: PEA-40 is a reliable carrier for cRGD and everolimus; the novel PEA-40 dual cRGD and everolimus stent coating both everolimus-dependently decreases coronary stenosis as well as integrin-dependently accelerates stent strut re-endothelialization as compared to everolimus-eluting stents in the porcine coronary overstretch model. Therefore, the concerted acceleration of vascular healing by facilitated homing of circulating EPCs and distinct antiproliferatory properties of everolimus might transfer to an improvement of stent safety while stent efficacy is maintained.

scholarly journals Do ultrathin strut bare-metal stents with passive coating improve efficacy in large coronary arteries? Insights from the randomized, multicenter BASKET-PROVE trials

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Kim Wadt Hansen ◽  
Raban Jeger ◽  
Rikke Sørensen ◽  
Christoph Kaiser ◽  
Matthias Pfisterer ◽  
...  
Keyword(s):  
Silicon Carbide ◽  
Coronary Arteries ◽  
Cardiac Death ◽  
Proportional Hazards ◽  
Bare Metal Stents ◽  
Metal Stents ◽  
Bare Metal ◽  
Cobalt Chromium ◽  
Stent Type ◽  
Large Coronary Arteries

Abstract Background The new generation thinner-strut silicon carbide (SiC) coated cobalt chromium (CoCr) bare-metal stents (BMS) are designed to accelerate rapid endothelialisation and reduce thrombogenicity when implanted in coronary arteries. However, smaller studies suggest higher rates of symptomatic restenosis in patients receiving the newer generation BMS. We investigated the efficacy of a newer generation ultrathin strut silicon-carbide coated cobalt-chromium (CoCr) BMS (SCC-BMS) as compared to an older thin-strut uncoated CoCr BMS (UC-BMS) in patients presenting with coronary artery disease requiring stenting of large vessels (≥3.0 mm). Methods All patients randomized to SCC- (n = 761) or UC-BMS (n = 765) in the two BASKET-PROVE trials were included. Design, patients, interventions and follow-up were similar between trials except differing regimens of dual antiplatelet therapy. The primary endpoint was clinically driven target-vessel revascularization within 24 months. Safety endpoints of cardiac death, non-fatal myocardial infarction (MI), and definite/probable stent thrombosis (ST) were also assessed. We used inverse probability weighted proportional hazards Cox regressions adjusting for known confounders. Results Demographics, clinical presentation, and risk factors were comparable between the groups, but patients receiving SCC-BMS underwent less complex procedures. The risk for clinically driven TVR was increased om the SCC-BMS group compared to the UC-BMS group (cumulative incidence, 10.6% vs. 8.4%; adjusted relative hazard [HR], 1.49 [95% CI, 1.05–2.10]). No differences in safety endpoints were detected, cardiac death (1.6% vs. 2.8%; HR, 0.62 [CI, 0.30–1.27]), non-fatal MI (3.2% vs. 2.5%; HR, 1.56 [CI, 0.83–2.91]), and definite/probable ST (0.8% vs. 1.1%; HR, 1.17 [CI, 0.39–3.50]). Differences in strut thickness between the two stents did not explain the association between stent type and clinically driven TVR. Conclusions In patients requiring stenting of large coronary arteries, use of the newer generation SCC-BMS was associated with a higher risk of clinically driven repeat revascularization compared to the UC-BMS with no signs of an offsetting safety benefit.

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