Sex Differences in the Obesity Paradox of Systolic Heart Failure?

2011 ◽  
Vol 17 (8) ◽  
pp. S85
Author(s):  
Adrienne L. Clark ◽  
Tamara B. Horwich
Keyword(s):  
Heart Failure ◽  
Sex Differences ◽  
Systolic Heart Failure ◽  
Obesity Paradox

scholarly journals Exercise tolerance can explain the obesity paradox in patients with systolic heart failure: data from the MECKI Score Research Group

2016 ◽  
Vol 18 (5) ◽  
pp. 545-553 ◽  
Author(s):  
Massimo F. Piepoli ◽  
Ugo Corrà ◽  
Fabrizio Veglia ◽  
Alice Bonomi ◽  
Elisabetta Salvioni ◽  
...  
Keyword(s):  
Heart Failure ◽  
Research Group ◽  
Exercise Tolerance ◽  
Systolic Heart Failure ◽  
Obesity Paradox ◽  
Failure Data

scholarly journals The Obesity Paradox in Men Versus Women With Systolic Heart Failure

2012 ◽  
Vol 110 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Adrienne L. Clark ◽  
Jennifer Chyu ◽  
Tamara B. Horwich
Keyword(s):  
Heart Failure ◽  
Systolic Heart Failure ◽  
Obesity Paradox

scholarly journals Sex differences in the central and peripheral manifestations of ischemia-induced heart failure in rats

2019 ◽  
Vol 316 (1) ◽  
pp. H70-H79 ◽  
Author(s):  
Yang Yu ◽  
Shun-Guang Wei ◽  
Robert M. Weiss ◽  
Robert B. Felder
Keyword(s):  
Heart Failure ◽  
Sex Differences ◽  
Ventricular Remodeling ◽  
Systolic Heart Failure ◽  
Left Ventricular ◽  
Female Rats ◽  
Coronary Artery Ligation ◽  
Mrna Levels ◽  
Ang Ii ◽  
Hemodynamic Compromise

Sex differences in the presentation, outcome, and responses to treatment of systolic heart failure (HF) have been reported. In the present study, we examined the effect of sex on central neural mechanisms contributing to neurohumoral excitation and its peripheral manifestations in rats with HF. Male and female Sprague-Dawley rats underwent coronary artery ligation (CL) to induce HF. Age-matched rats served as controls. Ischemic zone and left ventricular function were similar 24 h and 4 wk after CL. Female rats with HF had a lower mortality rate and less hemodynamic compromise, pulmonary congestion, and right ventricular remodeling 4 wk after CL. Plasma angiotensin II (ANG II), arginine vasopressin (AVP), and norepinephrine levels were increased in HF rats in both sexes, but AVP and norepinephrine levels increased less in female rats. In the hypothalamic paraventricular nucleus, a key cardiovascular-related nucleus contributing to neurohumoral excitation in HF, mRNA levels for the proinflammatory cytokines tumor necrosis factor-α and interleukin-1β as well as cyclooxygenase-2 and the ANG II type 1a receptor were increased in HF rats of both sexes, but less so in female rats. Angiotensin-converting enzyme 2 protein levels increased in female HF rats but decreased in male HF rats. mRNA levels of AVP were lower in female rats in both control and HF groups compared with the respective male groups. Activation of extracellular signal-regulated protein kinases 1 and 2 increased similarly in both sexes in HF. The results suggest that female HF rats have less central neural excitation and less associated hemodynamic compromise than male HF rats with the same degree of initial ischemic cardiac injury. NEW & NOTEWORTHY Sex differences in the presentation and responses to treatment of heart failure (HF) are widely recognized, but the underlying mechanisms are poorly understood. The present study describes sex differences in the central nervous system mechanisms that drive neurohumoral excitation in ischemia-induced HF. Female rats had a less intense central neurochemical response to HF and experienced less hemodynamic compromise. Sex hormones may contribute to these differences in the central and peripheral adaptations to HF.

Body composition and prognosis in chronic systolic heart failure: the obesity paradox

2003 ◽  
Vol 91 (7) ◽  
pp. 891-894 ◽  
Author(s):  
Carl J. Lavie ◽  
Ahmed F. Osman ◽  
Richard V. Milani ◽  
Mandeep R. Mehra
Keyword(s):  
Heart Failure ◽  
Body Composition ◽  
Systolic Heart Failure ◽  
Obesity Paradox ◽  
Chronic Systolic Heart Failure

Is There a Gender Difference of Obesity Paradox in Systolic Heart Failure? Gender Difference of Obesity Paradox

2014 ◽  
Vol 20 (10) ◽  
pp. S192
Author(s):  
Byung-Su Yoo ◽  
Seok-Min Kang ◽  
Eun-Seok Jeon ◽  
Dong-Ju Choi ◽  
Myeong-Chan Cho ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gender Difference ◽  
Systolic Heart Failure ◽  
Obesity Paradox

scholarly journals Is There a Sex-Related Difference in the Obesity Paradox in Systolic Heart Failure? Sex-Related Difference in the Obesity Paradox

2018 ◽  
Vol 59 (1) ◽  
pp. 57 ◽  
Author(s):  
Soonchang Hong ◽  
Ji Hyun Lee ◽  
Kyung Min Kim ◽  
Jun-Won Lee ◽  
Young-Jin Youn ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systolic Heart Failure ◽  
Obesity Paradox ◽  
Related Difference
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